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作者：Ross, Jennifer L.
作者单位：Syracuse University
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作者：Helena-Bueno, Karla; Rybak, Mariia Yu.; Ekemezie, Chinenye L.; Sullivan, Rudi; Brown, Charlotte R.; Dingwall, Charlotte; Basle, Arnaud; Schneider, Claudia; Connolly, James P. R.; Blaza, James N.; Csoergo, Balint; Moynihan, Patrick J.; Gagnon, Matthieu G.; Hill, Chris H.; Melnikov, Sergey V.
作者单位：Newcastle University - UK; University of Texas System; University of Texas Medical Branch Galveston; University of Birmingham; University of York - UK; University of York - UK; University of York - UK; HUN-REN; HUN-REN Biological Research Center; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of York - UK
摘要：To conserve energy during starvation and stress, many organisms use hibernation factor proteins to inhibit protein synthesis and protect their ribosomes from damage1,2. In bacteria, two families of hibernation factors have been described, but the low conservation of these proteins and the huge diversity of species, habitats and environmental stressors have confounded their discovery3-6. Here, by combining cryogenic electron microscopy, genetics and biochemistry, we identify Balon, a new hibern...
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作者：Hruska-Plochan, Marian; Wiersma, Vera I.; Betz, Katharina M.; Mallona, Izaskun; Ronchi, Silvia; Maniecka, Zuzanna; Hock, Eva-Maria; Tantardini, Elena; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Perez-Berlanga, Manuela; Gatta, Beatrice; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Sharma, Puneet; De Vos, Laura; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D.; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini
作者单位：University of Zurich; University of Zurich; Swiss Institute of Bioinformatics; University of Zurich; University of Zurich; Masaryk University; University of Bern; University of Zurich; University of London; University College London; University of London; University College London
摘要：Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2-5 that cannot be directly studied in animal models. Here, to explore the emergence and consequences of TDP-43 pathologies, we generated induced pluripotent stem cell-derived, colony morphology neural stem cells (iCoMoNSCs) via manual selection of neur...
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作者：Larsen, Lydia
摘要：Massive environmental DNA project will take a record-setting snapshot of biodiversity worldwide.
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作者：Carlson, Colin; Becker, Daniel; Happi, Christian; O'Donoghue, Zoe; de Oliveira, Tulio; Oyola, Samuel O.; Poisot, Timothee; Seifert, Stephanie; Phelan, Alexandra
作者单位：Georgetown University; University of Oklahoma System; University of Oklahoma - Norman; Redeemers University; Redeemers University; Stellenbosch University; Stellenbosch University; University of Kwazulu Natal; CGIAR; International Livestock Research Institute (ILRI); CGIAR; International Livestock Research Institute (ILRI); Universite de Montreal; Washington State University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
摘要：The proposed Pandemic Agreement must ensure that COVID-19 vaccine nationalism is never repeated; 290 scientists call for action. The proposed Pandemic Agreement must ensure that COVID-19 vaccine nationalism is never repeated; 290 scientists call for action.
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作者：Huang, Yu-Hwa; Zhu, Chen; Kondo, Yasuyuki; Anderson, Ana C.; Gandhi, Amit; Russell, Andrew; Dougan, Stephanie K.; Petersen, Britt-Sabina; Melum, Espen; Pertel, Thomas; Clayton, Kiera L.; Raab, Monika; Chen, Qiang; Beauchemin, Nicole; Yazaki, Paul J.; Pyzik, Michal; Ostrowski, Mario A.; Glickman, Jonathan N.; Rudd, Christopher E.; Ploegh, Hidde L.; Franke, Andre; Petsko, Gregory A.; Kuchroo, Vijay K.; Blumberg, Richard S.
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作者：Makhovych, Inna
作者单位：Ministry of Education & Science of Ukraine; Kyiv National University of Technologies & Design
摘要：Ukraine's universities have adapted by blending innovative forms of remote learning. Lessons from this experiment are relevant to the rest of the world.
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作者：Wild, Sarah
摘要：Prestigious awards such as the Fields Medal, Abel Prize and Breakthrough Prize have been awarded predominantly to men.
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作者：Qiu, Chengxiang; Martin, Beth K.; Welsh, Ian C.; Daza, Riza M.; Le, Truc-Mai; Huang, Xingfan; Nichols, Eva K.; Taylor, Megan L.; Fulton, Olivia; O'Day, Diana R.; Gomes, Anne Roshella; Ilcisin, Saskia; Srivatsan, Sanjay; Deng, Xinxian; Disteche, Christine M.; Noble, William Stafford; Hamazaki, Nobuhiko; Moens, Cecilia B.; Kimelman, David; Cao, Junyue; Schier, Alexander F.; Spielmann, Malte; Murray, Stephen A.; Trapnell, Cole; Shendure, Jay
作者单位：University of Washington; University of Washington Seattle; Jackson Laboratory; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Rockefeller University; University of Basel; Max Planck Society; University of Lubeck; University of Kiel; Schleswig Holstein University Hospital; University of Kiel; German Centre for Cardiovascular Research
摘要：The house mouse (Mus musculus) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans1,2. Mouse gestation lasts only 3 weeks, during which the genome orchestrates the astonishing transformation of a single-cell zygote into a free-living pup composed of more than 500 million cells. Here, to establish a global framework for exploring mammalian development, we applied optimized single-cell combinatorial indexing3 to profile the transcriptional st...
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作者：Gibney, Elizabeth
摘要：The EU AI Act is the world's first major legislation on artificial intelligence and strictly regulates general-purpose models.
