2025

最新文章

• Learning-associated astrocyte ensembles regulate memory recall AI翻译
  作者：Williamson, Michael R.; Kwon, Wookbong; Woo, Junsung; Ko, Yeunjung; Maleki, Ehson; Yu, Kwanha; Murali, Sanjana; Sardar, Debosmita; Deneen, Benjamin
  作者单位：Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
  摘要：The physical manifestations of memory formation and recall are fundamental questions that remain unresolved(1). At the cellular level, ensembles of neurons called engrams are activated by learning events and control memory recall(1-5). Astrocytes are found in close proximity to neurons and engage in a range of activities that support neurotransmission and circuit plasticity(6-10). Moreover, astrocytes exhibit experience-dependent plasticity(11-13), although whether specific ensembles of astroc...
• How quantum mechanics emerged in a few revolutionary months 100 years ago AI翻译
  作者：Camilleri, Kristian
  作者单位：University of Melbourne
  摘要：It began with concerns about the orbits used to explain the motion of electrons in atoms - but quantum theory ended up upending reality itself. It began with concerns about the orbits used to explain the motion of electrons in atoms - but quantum theory ended up upending reality itself.
• FBP1 controls liver cancer evolution from senescent MASH hepatocytes AI翻译
  作者：Gu, Li; Zhu, Yahui; Nandi, Shuvro P.; Lee, Maiya; Watari, Kosuke; Bareng, Breanna; Ohira, Masafumi; Liu, Yuxiao; Sakane, Sadatsugu; Carlessi, Rodrigo; Sauceda, Consuelo; Dhar, Debanjan; Ganguly, Souradipta; Hosseini, Mojgan; Teneche, Marcos G.; Adams, Peter D.; Gonzalez, David J.; Kisseleva, Tatiana; Tirnitz-Parker, Janina E. E.; Simon, M. Celeste; Alexandrov, Ludmil B.; Karin, Michael
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Sichuan University; Sichuan University; Chongqing University; Sichuan University; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Curtin University; University of Western Australia; Harry Perkins Institute of Medical Research; Queen Elizabeth II Medical Centre; University of Western Australia; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Sanford Burnham Prebys Medical Discovery Institute; University of Pennsylvania; University of Pennsylvania
  摘要：Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH)(1). While increasing HCC risk(2), MASH triggers p53-dependent hepatocyte senescence(3), which we found to parallel hypernutrition-induced DNA breaks. How this tumour-suppressive response is bypassed to license oncogenic mutagenesis and enable HCC evolution was previously unclear. Here we identifie...
• Computational microscopy with coherent diffractive imaging and ptychography AI翻译
  作者：Miao, Jianwei
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Microscopy and crystallography are two essential experimental methodologies for advancing modern science. They complement one another, with microscopy typically relying on lenses to image the local structures of samples, and crystallography using diffraction to determine the global atomic structure of crystals. Over the past two decades, computational microscopy, encompassing coherent diffractive imaging (CDI) and ptychography, has advanced rapidly, unifying microscopy and crystallography to o...
• Molecular mechanism of IgE-mediated FcεRI activation AI翻译
  作者：Chen, Mengying; Su, Qiang; Shi, Yigong
  作者单位：Westlake University; Westlake Laboratory; Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART)
  摘要：Allergic diseases affect more than a quarter of individuals in industrialized countries, and are a major public health concern(1,2). The high-affinity Fc receptor for immunoglobulin E (Fc epsilon RI), which is mainly present on mast cells and basophils, has a crucial role in allergic diseases(3-5). Monomeric immunoglobulin E (IgE) binding to Fc epsilon RI regulates mast cell survival, differentiation and maturation(6-8). However, the underlying molecular mechanism remains unclear. Here we demo...
• WHY KIDS NEED MORE CHANCES TO TAKE RISKS AI翻译
  作者：Nowogrodzki, Julian
• We need to talk about human genome editing AI翻译
  作者：[Anonymous]
  摘要：In a few decades, gene-editing technologies could reduce the likelihood of common human diseases. Societies must use this time to prepare for their arrival. In a few decades, gene-editing technologies could reduce the likelihood of common human diseases. Societies must use this time to prepare for their arrival.
• The skin's 'surprise' power: it has its very own immune system AI翻译
  作者：Guglielmi, Giorgia
• Electrochemical synthesis goes wireless AI翻译
  作者：O'Brien, Thomas M.; Lennox, Alastair J. J.
  作者单位：University of Bristol
• What do people eat and why do they eat it? AI翻译
  作者：O'Brien, Thomas M.; Lennox, Alastair J. J.
  作者单位：University of Bristol
  摘要：A 1975 report sparks a debate about the place of sociology in human nutrition research, and a crystal-clear lecture on chemical morphology, in our weekly dip into Nature's archive. Snippets from Nature's past.