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作者：O'Brien, Thomas M.; Lennox, Alastair J. J.
作者单位：University of Bristol
摘要：Electrochemical reactions for organic synthesis typically require intricate, specialized equipment, slowing progress in this field. Minuscule electric generators now enable faster reaction discovery and development. High-throughput electrochemistry driven by microelectronic devices.
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作者：Raps, Felix C.; Rivas-Souchet, Ariadna; Jones, Chey M.; Hyster, Todd K.
作者单位：Princeton University; Cornell University; Merck & Company; Merck & Company USA
摘要：C-N bond formation is integral to modern chemical synthesis owing to the ubiquity of nitrogen heterocycles in small-molecule pharmaceuticals and agrochemicals. Alkene hydroamination with unactivated alkenes is an atom-economical strategy for constructing these bonds. However, these reactions are challenging to render asymmetric when preparing fully substituted carbon stereocentres. Here we report a photoenzymatic alkene hydroamination to prepare 2,2-disubstituted pyrrolidines by a Baeyer-Villi...
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作者：Gvirtzman, Shahar; Kammer, David S.; Adda-Bedia, Mokhtar; Fineberg, Jay
作者单位：Hebrew University of Jerusalem; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Ecole Normale Superieure de Lyon (ENS de LYON)
摘要：Frictional motion is mediated by rapidly propagating ruptures that detach the ensemble of contacts forming the frictional interface between contacting bodies(1-7). These ruptures are similar to shear cracks. When this process takes place in natural faults, these rapid ruptures are essentially earthquakes(8,9). Although fracture mechanics describe the rapid motion of these singular objects, the nucleation process that creates them is not understood(10-19). Here we fully describe the nucleation ...
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作者：Swingle, Kelsey L.; Hamilton, Alex G.; Safford, Hannah C.; Geisler, Hannah C.; Thatte, Ajay S.; Palanki, Rohan; Murray, Amanda M.; Han, Emily L.; Mukalel, Alvin J.; Han, Xuexiang; Joseph, Ryann A.; Ghalsasi, Aditi A.; Alameh, Mohamad-Gabriel; Weissman, Drew; Mitchell, Michael J.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Pre-eclampsia is a placental disorder that affects 3-5% of all pregnancies and is a leading cause of maternal and fetal morbidity worldwide(1,2). With no drug available to slow disease progression, engineering ionizable lipid nanoparticles (LNPs) for extrahepatic messenger RNA (mRNA) delivery to the placenta is an attractive therapeutic option for pre-eclampsia. Here we use high-throughput screening to evaluate a library of 98 LNP formulations in vivo and identify a placenta-tropic LNP (LNP 55...
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作者：Xu, Qingshuai; Li, Tan; Ju, Zhijin; Chen, Guangxu; Ye, Daiqi; Waterhouse, Geoffrey I. N.; Lu, Yingying; Lai, Xuejun; Zhou, Guangmin; Guo, Lin; Yan, Keyou; Tao, Xinyong; Li, Hong; Qiu, Yongcai
作者单位：South China University of Technology; Wenzhou University; University of Auckland; Zhejiang University; Tsinghua University; Beihang University; Zhejiang University of Technology; Chinese Academy of Sciences
摘要：Lithium (Li) metal batteries (LMBs) are promising for high-energy-density rechargeable batteries(1-3). However, Li dendrites formed by the reaction between highly active Li and non-aqueous electrolytes lead to safety concerns and rapid capacity decay(4-7). Developing a reliable solid-electrolyte interphase is critical for realizing high-rate and long-life LMBs, but remains technically challenging(4,8). Here we demonstrate that adding excess m-Li2ZrF6 (monoclinic) nanoparticles to a commercial ...
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作者：Meex, Steven J. R.; Aakre, Kristin Moberg
作者单位：Maastricht University; Maastricht University; University of Bergen; Haukeland University Hospital; University of Bergen; Haukeland University Hospital; University of Bergen
摘要：In medicine, a person's blood-test results are compared with the average range in a population. But results are highly individual and tightly regulated around a person's own stable values. Changes to these values can indicate disease.
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作者：Thadhani, Ravi; Karumanchi, S. Ananth
作者单位：Emory University; Cedars Sinai Medical Center
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作者：Manning, Preston
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作者：Van Noorden, Richard
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作者：Wagner, Marek; Nishikawa, Hiroyoshi; Koyasu, Shigeo
作者单位：Nagoya University; National Cancer Center - Japan; RIKEN
摘要：Our understanding of type 2 immunity has undergone a substantial transformation in recent years, revealing previously unknown functions. Beyond its canonical role in defence against parasitic helminth infections, type 2 immunity safeguards the host through additional mechanisms, including the suppression of excessive type 1 immune responses, regulation of tissue repair and maintenance of adipose tissue homeostasis. However, unlike type 1 immune responses, type 2 immunity is perceived as a pote...
