作者：Foy, Brody H.; Petherbridge, Rachel; Roth, Maxwell T.; Zhang, Cindy; De Souza, Daniel C.; Mow, Christopher; Patel, Hasmukh R.; Patel, Chhaya H.; Ho, Samantha N.; Lam, Evie; Powe, Camille E.; Hasserjian, Robert P.; Karczewski, Konrad J.; Tozzo, Veronica; Higgins, John M.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of Washington; University of Washington Seattle; Adventist Health Services; AdventHealth; Mass General Brigham; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：The complete blood count (CBC) is an important screening tool for healthy adults and a common test at periodic exams. However, results are usually interpreted relative to one-size-fits-all reference intervals(1,2), undermining the precision medicine goal to tailor care for patients on the basis of their unique characteristics(3,4). Here we study thousands of diverse patients at an academic medical centre and show that routine CBC indices fluctuate around stable values or setpoints(5), and setp...
作者：Bhardwaj, Abhishek; Panepinto, Maria C.; Ueberheide, Beatrix; Neel, Benjamin G.
作者单位：New York University; NYU Langone Medical Center; New York University; New York University; New York University
摘要：Hypoxic cancer cells resist many antineoplastic therapies and can seed recurrence(1,2). We previously found that either deficiency or inhibition of protein-tyrosine phosphatase (PTP1B) promotes human epidermal growth factor receptor 2-positive breast cancer cell death in hypoxia by activation of RNF213 (ref. 3), a large protein with multiple AAA-ATPase domains and two ubiquitin ligase domains (RING and RZ) implicated in Moyamoya disease, lipotoxicity and innate immunity(4). Here we report that...
作者：Muindi, Fanuel
作者单位：Northeastern University
作者：Nowogrodzki, Julian
摘要：Studies reveal how risky play can benefit child development. But encouraging it can be a challenge for parents. Studies reveal how risky play can benefit child development. But encouraging it can be a challenge for parents.
作者：McElfresh, Duncan C.
作者单位：Stanford University; Stanford Medicine
作者：[Anonymous]
摘要：A century ago, physics had its Darwinian moment - a change in perspective that was as consequential for the physical sciences as the theory of evolution by natural selection was for biology. A century ago, physics had its Darwinian moment - a change in perspective that was as consequential for the physical sciences as the theory of evolution by natural selection was for biology.
