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作者：Cvetkovska, Marina
作者单位：University of Ottawa
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作者：Duchene, Carole; Bouly, Jean-Pierre; Pierella Karlusich, Juan Jose; Vernay, Emeline; Selles, Julien; Bailleul, Benjamin; Bowler, Chris; d'Alcala, Maurizio Ribera; Falciatore, Angela; Jaubert, Marianne
作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Stazione Zoologica Anton Dohrn; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Museum National d'Histoire Naturelle (MNHN); Massachusetts Institute of Technology (MIT)
摘要：Aquatic life is strongly structured by the distribution of light, which, besides attenuation in intensity, exhibits a continuous change in the spectrum with depth1. The extent to which these light changes are perceived by phytoplankton through photoreceptors is still inadequately known. We addressed this issue by integrating functional studies of diatom phytochrome (DPH) photoreceptors in model species2 with environmental surveys of their distribution and activity. Here, by developing an in vi...
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作者：Rito, Tiago; Libby, Ashley R. G.; Demuth, Madeleine; Domart, Marie-Charlotte; Cornwall-Scoones, Jake; Briscoe, James
作者单位：Francis Crick Institute
摘要：The formation of the vertebrate body involves the coordinated production of trunk tissues from progenitors located in the posterior of the embryo. Although in vitro models using pluripotent stem cells replicate aspects of this process1, 2, 3, 4, 5, 6, 7, 8, 9-10, they lack crucial components, most notably the notochord-a defining feature of chordates that patterns surrounding tissues11. Consequently, cell types dependent on notochord signals are absent from current models of human trunk format...
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作者：[Anonymous]
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作者：Tollefson, Jeff
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作者：Tacon, Dave; Han, Sang-Wook
作者单位：Korea Institute of Science & Technology (KIST)
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作者：[Anonymous]
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作者：Witze, Alexandra
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作者：Visscher, Peter M.; Gyngell, Christopher; Yengo, Loic; Savulescu, Julian
作者单位：University of Queensland; University of Oxford; Murdoch Children's Research Institute; University of Melbourne; University of Oxford; National University of Singapore
摘要：Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present1, 2-3. To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases. In this Analysis, we show that polygenic genome editing could theoretically yield extreme red...
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作者：Huang, Peiwu; Gao, Weina; Fu, Changying; Wang, Min; Li, Yunguang; Chu, Bizhu; He, An; Li, Yuan; Deng, Xiaomei; Zhang, Yehan; Kong, Qian; Yuan, Jingxiong; Wang, Hebin; Shi, Yu; Gao, Dong; Qin, Renyi; Hunter, Tony; Tian, Ruijun
作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Southern University of Science & Technology; Southern University of Science & Technology; Huazhong University of Science & Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Salk Institute; Shenzhen Bay Laboratory; Bristol-Myers Squibb
摘要：Pancreatic ductal adenocarcinoma (PDAC) has an atypical, highly stromal tumour microenvironment (TME) that profoundly contributes to its poor prognosis1. Here, to better understand the intercellular signalling between cancer and stromal cells directly in PDAC tumours, we developed a multidimensional proteomic strategy called TMEPro. We applied TMEPro to profile the glycosylated secreted and plasma membrane proteome of 100 human pancreatic tissue samples to a great depth, define cell type origi...
