2025

最新文章

• Particle accelerators get an assist from AI co-pilots AI翻译
  作者：[Anonymous]
• Macrophages excite muscle spindles with glutamate to bolster locomotion AI翻译
  作者：Yan, Yuyang; Antolin, Nuria; Zhou, Luming; Xu, Luyang; Vargas, Irene Lisa; Gomez, Carlos Daniel; Kong, Guiping; Palmisano, Ilaria; Yang, Yi; Chadwick, Jessica; Mueller, Franziska; Bull, Anthony M. J.; Lo Celso, Cristina; Primiano, Guido; Servidei, Serenella; Perrier, Jean Francois; Bellardita, Carmelo; Di Giovanni, Simone
  作者单位：Imperial College London; Imperial College London; University of Copenhagen; Imperial College London; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
  摘要：The stretch reflex is a fundamental component of the motor system that orchestrates the coordinated muscle contractions underlying movement. At the heart of this process lie the muscle spindles (MS), specialized receptors finely attuned to fluctuations in tension within intrafusal muscle fibres. The tension variation in the MS triggers a series of neuronal events including an initial depolarization of sensory type Ia afferents that subsequently causes the activation of motoneurons within the s...
• NASA still has no plan for how to bring precious Mars rocks to Earth AI翻译
  作者：Witze, Alexandra
• Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis AI翻译
  作者：Tsukahara, Sayuri; Bousios, Alexandros; Perez-Roman, Estela; Yamaguchi, Sota; Leduque, Basile; Nakano, Aimi; Naish, Matthew; Osakabe, Akihisa; Toyoda, Atsushi; Ito, Hidetaka; Edera, Alejandro; Tominaga, Sayaka; Juliarni, Kae; Kato, Kae; Oda, Shoko; Inagaki, Soichi; Lorkovic, Zdravko; Nagaki, Kiyotaka; Berger, Frederic; Kawabe, Akira; Quadrana, Leandro; Henderson, Ian; Kakutani, Tetsuji
  作者单位：University of Tokyo; University of Sussex; Universite Paris Saclay; INRAE; Universite Paris Cite; University of Cambridge; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Hokkaido University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Vienna Biocenter (VBC); Austrian Academy of Sciences; Okayama University; Kyoto Sangyo University
  摘要：In organisms ranging from vertebrates to plants, major components of centromeres are rapidly evolving repeat sequences, such as tandem repeats (TRs) and transposable elements (TEs), which harbour centromere-specific histone H3 (CENH3)1,2. Complete centromere structures recently determined in human and Arabidopsis suggest frequent integration and purging of retrotransposons within the TR regions of centromeres3, 4-5. Despite the high impact of 'centrophilic' retrotransposons on the paradox of r...
• π-HuB: the proteomic navigator of the human body (Vol 636, pg 322, 2024) AI翻译
  作者：He, Fuchu; Aebersold, Ruedi; Baker, Mark S.; Bian, Xiuwu; Bo, Xiaochen; Chan, Daniel W.; Chang, Cheng; Chen, Luonan; Chen, Xiangmei; Chen, Yu-Ju; Cheng, Heping; Collins, Ben C.; Corrales, Fernando; Cox, Juergen; E, Weinan; Van Eyk, Jennifer E.; Fan, Jia; Faridi, Pouya; Figeys, Daniel; Gao, George Fu; Gao, Wen; Gao, Zu-Hua; Goda, Keisuke; Goh, Wilson Wen Bin; Gu, Dongfeng; Guo, Changjiang; Guo, Tiannan; He, Yuezhong; Heck, Albert J. R.; Hermjakob, Henning; Hunter, Tony; Iyer, Narayanan Gopalakrishna; Jiang, Ying; Jimenez, Connie R.; Joshi, Lokesh; Kelleher, Neil L.; Li, Ming; Li, Yang; Lin, Qingsong; Liu, Cui Hua; Liu, Fan; Liu, Guang-Hui; Liu, Yansheng; Liu, Zhihua; Low, Teck Yew; Lu, Ben; Mann, Matthias; Meng, Anming; Moritz, Robert L.; Nice, Edouard; Ning, Guang; Omenn, Gilbert S.; Overall, Christopher M.; Palmisano, Giuseppe; Peng, Yaojin; Pineau, Charles; Poon, Terence Chuen Wai; Purcell, Anthony W.; Qiao, Jie; Reddel, Roger R.; Robinson, Phillip J.; Roncada, Paola; Sander, Chris; Sha, Jiahao; Song, Erwei; Srivastava, Sanjeeva; Sun, Aihua; Sze, Siu Kwan; Tang, Chao; Tang, Liujun; Tian, Ruijun; Vizcaino, Juan Antonio; Wang, Chanjuan; Wang, Chen; Wang, Xiaowen; Wang, Xinxing; Wang, Yan; Weiss, Tobias; Wilhelm, Mathias; Winkler, Robert; Wollscheid, Bernd; Wong, Limsoon; Xie, Linhai; Xie, Wei; Xu, Tao; Xu, Tianhao; Yan, Liying; Yang, Jing; Yang, Xiao; Yates, John; Yun, Tao; Zhai, Qiwei; Zhang, Bing; Zhang, Hui; Zhang, Lihua; Zhang, Lingqiang; Zhang, Pingwen; Zhang, Yukui; Zheng, Yu Zi; Zhong, Qing; Zhu, Yunping; IT-HuB Consortium, Daniel W.
• The mechanism of mRNA cap recognition AI翻译
  作者：Gentry, Riley C.; Ide, Nicholas A.; Comunale, Victoria M.; Hartwick, Erik W.; Kinz-Thompson, Colin D.; Gonzalez Jr, Ruben L.
  作者单位：Columbia University; Columbia University; University of Colorado System; University of Colorado Boulder; Rutgers University System; Rutgers University Newark
  摘要：During translation initiation, mRNA molecules must be identified and activated for loading into a ribosome1, 2-3. In this rate-limiting step, the heterotrimeric protein eukaryotic initiation factor eIF4F must recognize and productively interact with the 7-methylguanosine cap at the 5 ' end of the mRNA and subsequently activate the message1, 2-3. Despite its fundamental, regulatory role in gene expression, the molecular events underlying cap recognition and mRNA activation remain unclear3. Here...
• The human and non-human primate developmental GTEx projects AI翻译
  作者：Coorens, Tim H. H.; Guillaumet-Adkins, Amy; Kovner, Rothem; Linn, Rebecca L.; Roberts, Victoria H. J.; Sule, Amrita; Van Hoose, Patrick M.; the dGTEx Consortium, Thomas
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Oregon Health & Science University; Oregon National Primate Research Center
  摘要：Many human diseases are the result of early developmental defects. As most paediatric diseases and disorders are rare, children are critically underrepresented in research. Functional genomics studies primarily rely on adult tissues and lack critical cell states in specific developmental windows. In parallel, little is known about the conservation of developmental programmes across non-human primate (NHP) species, with implications for human evolution. Here we introduce the developmental Genot...
• Learning the fitness dynamics of pathogens from phylogenies AI翻译
  作者：Lefrancq, Noemie; Duret, Lorena; Bouchez, Valerie; Brisse, Sylvain; Parkhill, Julian; Salje, Henrik
  作者单位：University of Cambridge; University of Cambridge; Swiss Federal Institutes of Technology Domain; ETH Zurich; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
  摘要：The dynamics of the genetic diversity of pathogens, including the emergence of lineages with increased fitness, is a foundational concept of disease ecology with key public-health implications. However, the identification of such lineages and estimation of associated fitness remain challenging, and is rarely done outside densely sampled systems1,2. Here we present phylowave, a scalable approach that summarizes changes in population composition in phylogenetic trees, enabling the automatic dete...
• Joint speech and text machine translation for up to 100 languages AI翻译
  作者：Barrault, Loic; Chung, Yu-An; Meglioli, Mariano Coria; Dale, David; Dong, Ning; Duquenne, Paul-Ambroise; Elsahar, Hady; Gong, Hongyu; Heffernan, Kevin; Hoffman, John; Klaiber, Christopher; Li, Pengwei; Licht, Daniel; Maillard, Jean; Rakotoarison, Alice; Sadagopan, Kaushik Ram; Wenzek, Guillaume; Ye, Ethan; Akula, Bapi; Chen, Peng-Jen; El Hachem, Naji; Ellis, Brian; Gonzalez, Gabriel Mejia; Haaheim, Justin; Hansanti, Prangthip; Howes, Russ; Huang, Bernie; Hwang, Min-Jae; Inaguma, Hirofumi; Jain, Somya; Kalbassi, Elahe; Kallet, Amanda; Kulikov, Ilia; Lam, Janice; Li, Daniel; Ma, Xutai; Mavlyutov, Ruslan; Peloquin, Benjamin; Ramadan, Mohamed; Ramakrishnan, Abinesh; Sun, Anna; Tran, Kevin; Tran, Tuan; Tufanov, Igor; Vogeti, Vish; Wood, Carleigh; Yang, Yilin; Yu, Bokai; Andrews, Pierre; Balioglu, Can; Costa-jussa, Marta R.; Celebi, Onur; Elbayad, Maha; Gao, Cynthia; Guzman, Francisco; Kao, Justine; Lee, Ann; Mourachko, Alexandre; Pino, Juan; Popuri, Sravya; Ropers, Christophe; Saleem, Safiyyah; Schwenk, Holger; Tomasello, Paden; Wang, Changhan; Wang, Jeff; Wang, Skyler
  作者单位：Inria; University of California System; University of California Berkeley
  摘要：Creating the Babel Fish, a tool that helps individuals translate speech between any two languages, requires advanced technological innovation and linguistic expertise. Although conventional speech-to-speech translation systems composed of multiple subsystems performing translation in a cascaded fashion exist1, 2-3, scalable and high-performing unified systems4,5 remain underexplored. To address this gap, here we introduce SEAMLESSM4T-Massively Multilingual and Multimodal Machine Translation-a ...
• Diversity and biogeography of the bacterial microbiome in glacier-fed streams AI翻译
  作者：Ezzat, Leila; Peter, Hannes; Bourquin, Massimo; Busi, Susheel Bhanu; Michoud, Gregoire; Fodelianakis, Stilianos; Kohler, Tyler J.; Lamy, Thomas; Geers, Aileen; Pramateftaki, Paraskevi; Baier, Florian; Marasco, Ramona; Daffonchio, Daniele; Deluigi, Nicola; Wilmes, Paul; Styllas, Michail; Schoen, Martina; Tolosano, Matteo; De Staercke, Vincent; Battin, Tom J.
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Universite de Montpellier; Ifremer; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); UK Centre for Ecology & Hydrology (UKCEH); University of Luxembourg; Charles University Prague; King Abdullah University of Science & Technology; Universite Paris Cite
  摘要：The rapid melting of mountain glaciers and the vanishing of their streams is emblematic of climate change1,2. Glacier-fed streams (GFSs) are cold, oligotrophic and unstable ecosystems in which life is dominated by microbial biofilms2,3. However, current knowledge on the GFS microbiome is scarce4,5, precluding an understanding of its response to glacier shrinkage. Here, by leveraging metabarcoding and metagenomics, we provide a comprehensive survey of bacteria in the benthic microbiome across 1...