-
作者：Chawla, Dalmeet Singh
-
作者：Ings, Simon
-
作者：Jones, Nicola; Witze, Alexandra; Tollefson, Jeff; Kozlov, Max
-
作者：Li, Yi-Hao; Chekshin, Nikita; Lu, Yilin; Yu, Jin-Quan
作者单位：Scripps Research Institute
摘要：C-H activation is the most direct way of functionalizing organic molecules. Many advances in this field still require specific directing groups to achieve the necessary activity and selectivity. Developing C-H activation reactions directed by native functional groups is essential for their broad application in synthesis1. Over the past decade, several generations of bifunctional ligands developed have enabled C(sp3)-H activation reactions of free carboxylic acids2, free aliphatic amines3, nati...
-
作者：Buzzai, Anthony C.; Tueting, Thomas
作者单位：Otto von Guericke University
-
作者：Soliman, Alix
-
作者：Hollmann, Noah; Mueller, Samuel; Purucker, Lennart; Krishnakumar, Arjun; Koerfer, Max; Bin Hoo, Shi; Schirrmeister, Robin Tibor; Hutter, Frank
作者单位：University of Freiburg; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of Freiburg; University of Freiburg
摘要：Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science(1,2). The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is essential for various applications as diverse as biomedical risk models, drug discovery and materials science. Although deep learning has revolutionized learning from raw data and led to numerous high-profile...
-
作者：He, Zhisong; Dony, Leander; Fleck, Jonas Simon; Szalata, Artur; Li, Katelyn X.; Sliskovic, Irena; Lin, Hsiu-Chuan; Santel, Malgorzata; Atamian, Alexander; Quadrato, Giorgia; Sun, Jieran; Pasca, Sergiu P.; Camp, J. Gray; Theis, Fabian J.; Treutlein, Barbara
-
作者：Chen-Liaw, Alice; Aggarwala, Varun; Mogno, Ilaria; Haifer, Craig; Li, Zhihua; Eggers, Joseph; Helmus, Drew; Hart, Amy; Wehkamp, Jan; Lamouse-Smith, Esi S. N.; Kerby, Robert L.; Rey, Federico E.; Colombel, Jean Frederic; Kamm, Michael A.; Olle, Bernat; Norman, Jason M.; Menon, Rajita; Watson, Andrea R.; Crossett, Emily; Terveer, Elisabeth M.; Keller, Josbert J.; Borody, Thomas J.; Grinspan, Ari; Paramsothy, Sudarshan; Kaakoush, Nadeem O.; Dubinsky, Marla C.; Faith, Jeremiah J.
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Sydney; University of New South Wales Sydney; Icahn School of Medicine at Mount Sinai; Johnson & Johnson; Janssen Pharmaceuticals; University of Wisconsin System; University of Wisconsin Madison; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Haaglanden Medical Center; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Centre For Digestive Diseases; Macquarie University; University of New South Wales Sydney
摘要：Despite the fundamental role of bacterial strain variation in gut microbiota function(1-6), the number of unique strains of a species that can stably colonize the human intestine is still unknown for almost all species. Here we determine the strain richness (SR) of common gut species using thousands of sequenced bacterial isolates with paired metagenomes. We show that SR varies across species, is transferable by faecal microbiota transplantation, and is uniquely low in the gut compared with so...
-
作者：Ramirez, Sydney I.; Faraji, Farhoud; Hills, L. Benjamin; Lopez, Paul G.; Goodwin, Benjamin; Stacey, Hannah D.; Sutton, Henry J.; Hastie, Kathryn M.; Saphire, Erica Ollmann; Kim, Hyun Jik; Mashoof, Sara; Yan, Carol H.; DeConde, Adam S.; Levi, Gina; Crotty, Shane
