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作者：Wild, Sarah
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作者：Peacock, Thomas P.; Moncla, Louise; Dudas, Gytis; VanInsberghe, David; Sukhova, Ksenia; Lloyd-Smith, James O.; Worobey, Michael; Lowen, Anice C.; Nelson, Martha I.
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Pirbright Institute; Imperial College London; University of Pennsylvania; Vilnius University; Emory University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Arizona; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
摘要：Influenza A viruses have caused more documented global pandemics in human history than any other pathogen(1,2). High pathogenicity avian influenza viruses belonging to the H5N1 subtype are a leading pandemic risk. Two decades after H5N1 'bird flu' became established in poultry in Southeast Asia, its descendants have resurged(3), setting off a H5N1 panzootic in wild birds that is fuelled by: (1) rapid intercontinental spread, reaching South America and Antarctica for the first time(4,5); (2) fa...
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作者：Garcia-Cabau, Carla; Bartomeu, Anna; Tesei, Giulio; Cheung, Kai Chit; Pose-Utrilla, Julia; Pico, Sara; Balaceanu, Andreea; Duran-Arque, Berta; Fernandez-Alfara, Marcos; Martin, Judit; De Pace, Cesare; Ruiz-Perez, Lorena; Garcia, Jesus; Battaglia, Giuseppe; Lucas, Jose J.; Hervas, Ruben; Lindorff-Larsen, Kresten; Mendez, Raul; Salvatella, Xavier
作者单位：Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Copenhagen; University of Hong Kong; Autonomous University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); Instituto de Salud Carlos III; University of London; University College London; University of London; University College London; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona; University of Barcelona; ICREA
摘要：The inclusion of microexons by alternative splicing occurs frequently in neuronal proteins. The roles of these sequences are largely unknown, and changes in their degree of inclusion are associated with neurodevelopmental disorders(1). We have previously shown that decreased inclusion of a 24-nucleotide neuron-specific microexon in CPEB4, a RNA-binding protein that regulates translation through cytoplasmic changes in poly(A) tail length, is linked to idiopathic autism spectrum disorder (ASD)(2...
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作者：Marris, Emma
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作者：Santos-Duran, Gabriel N.; Cooper, Rory L.; Jahanbakhsh, Ebrahim; Timin, Grigorii; Milinkovitch, Michel C.
作者单位：University of Geneva; Swiss Institute of Bioinformatics
摘要：Amniote integumentary appendages constitute a diverse group of micro-organs, including feathers, hair and scales. These structures typically develop as genetically controlled units(1), the spatial patterning of which emerges from a self-organized chemical Turing system(2,3) with integrated mechanical feedback(4,5). The seemingly purely mechanical patterning of polygonal crocodile head scales provides an exception to this paradigm(6). However, the nature and origin of the mechanical stress fiel...
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作者：Karamanlis, Dimokratis; Khani, Mohammad H.; Schreyer, Helene M.; Zapp, Soeren J.; Mietsch, Matthias; Gollisch, Tim
作者单位：University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Leibniz Association; Deutsches Primatenzentrum (DPZ); German Centre for Cardiovascular Research; University of Gottingen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Geneva
摘要：The role of the vertebrate retina in early vision is generally described by the efficient coding hypothesis(1,2), which predicts that the retina reduces the redundancy inherent in natural scenes(3) by discarding spatiotemporal correlations while preserving stimulus information(4). It is unclear, however, whether the predicted decorrelation and redundancy reduction in the activity of ganglion cells, the retina's output neurons, hold under gaze shifts, which dominate the dynamics of the natural ...
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作者：Kondepudi, Akhil; Pekmezci, Melike; Hou, Xinhai; Scotford, Katie; Jiang, Cheng; Rao, Akshay; Harake, Edward S.; Chowdury, Asadur; Al-Holou, Wajd; Wang, Lin; Pandey, Aditya; Lowenstein, Pedro R.; Castro, Maria G.; Koerner, Lisa Irina; Roetzer-Pejrimovsky, Thomas; Widhalm, Georg; Camelo-Piragua, Sandra; Movahed-Ezazi, Misha; Orringer, Daniel A.; Lee, Honglak; Freudiger, Christian; Berger, Mitchel; Hervey-Jumper, Shawn; Hollon, Todd
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Michigan System; University of Michigan; Medical University of Vienna; Medical University of Vienna; University of Michigan System; University of Michigan; Rutgers University System; Rutgers University New Brunswick; New York University; University of Michigan System; University of Michigan; Medical University of Vienna
摘要：A critical challenge in glioma treatment is detecting tumour infiltration during surgery to achieve safe maximal resection(1-3). Unfortunately, safely resectable residual tumour is found in the majority of patients with glioma after surgery, causing early recurrence and decreased survival(4-6). Here we present FastGlioma, a visual foundation model for fast (<10 s) and accurate detection of glioma infiltration in fresh, unprocessed surgical tissue. FastGlioma was pretrained using large-scale se...
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作者：Das Adhikary, Gobinda; Adukkadan, Anil; Muleta, Gudeta Jafo; Monika; Singh, Ram Prakash; Singh, Digvijay Narayan; Luo, Harvey; Tina, Getaw Abebe; Giles, Luke; Checchia, Stefano; Daniels, John; Ranjan, Rajeev
作者单位：Indian Institute of Science (IISC) - Bangalore; University of New South Wales Sydney; European Synchrotron Radiation Facility (ESRF)
摘要：Piezoelectric materials directly convert between electrical and mechanical energies. They are used as transducers in applications such as nano-positioning and ultrasound imaging. Improving the properties of these devices requires piezoelectric materials capable of delivering a large longitudinal strain on the application of an electric field. A large longitudinal strain of more than 1% is generally anticipated in suitably oriented single crystals of specific compositions of ferroelectric mater...
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作者：Zhang, Naiyuan J.; Nguyen, Ron Q.; Batra, Navketan; Liu, Xiaoxue; Watanabe, Kenji; Taniguchi, Takashi; Feldman, D. E.; Li, J. I. A.
作者单位：Brown University; Brown University; National Institute for Materials Science; National Institute for Materials Science; Shanghai Jiao Tong University
摘要：Excitons, Coulomb-driven bound states of electrons and holes, are typically composed of integer charges(1,2). However, inbilayersystems influenced by charge fractionalization(3,4), a more interesting form of interlayer exciton can emerge, in which pairing occurs between constituents that carry fractional charges. Despite numerous theoretical predictions for these fractional excitons(5-16), their experimental observation has remained unexplored. Here we report transport signatures of excitonic ...
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作者：Thorpe, Alan
作者单位：University of Reading
