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作者：Qureshi, Nusrat Shahin; Duss, Olivier
作者单位：European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL)
摘要：A central question in biology is how macromolecular machines function cooperatively. In bacteria, transcription and translation occur in the same cellular compartment, and can be physically and functionally coupled1-4. Although high-resolution structures of the ribosome-RNA polymerase (RNAP) complex have provided initial mechanistic insights into the coupling process5-10, we lack knowledge of how these structural snapshots are placed along a dynamic reaction trajectory. Here we reconstitute a ...
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作者：Sun, Fengxiu; Zhao, Zhenzhen; Willoughby, Mathilda M.; Shen, Shuaiqi; Zhou, Yu; Shao, Yiyan; Kang, Jing; Chen, Yongtian; Chen, Mengying; Yuan, Xiaojing; Hamza, Iqbal; Reddi, Amit R.; Chen, Caiyong
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作者：Bernard, Elliott M.; Broz, Petr
作者单位：University of Lausanne
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作者：Pourmal, Sergei; Truong, Melissa E.; Johnson, Matthew C.; Yang, Ying; Zhou, Lijuan; Alegre, Kamela; Stowe, Irma B.; Gupta, Shalini; Chen, Phoebe A.; Zhang, Yingnan; Rohou, Alexis; Newton, Kim; Kayagaki, Nobuhiko; Dixit, Vishva M.; Deshpande, Ishan
作者单位：Roche Holding; Roche Holding USA; Genentech; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Genentech; Roche Holding USA
摘要：Lytic cell death culminates in plasma membrane rupture, which releases large intracellular molecules to augment the inflammatory response. Plasma membrane rupture is mediated by the effector membrane protein ninjurin-1 (NINJ1)(1), which polymerizes and ruptures the membrane via its hydrophilic face(1-4). How NINJ1 is restrained under steady-state conditions to ensure cell survival remains unknown. Here we describe the molecular underpinnings of NINJ1 inhibition. Using cryogenic electron micros...
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作者：Thadhani, Ravi; Karumanchi, S. Ananth
作者单位：Emory University; Cedars Sinai Medical Center
摘要：Pre-eclampsia is a common and dangerous pregnancy-related illness. Using tiny lipid particles to deliver messenger RNA directly to the placenta to boost blood-vessel function might prove to be an effective treatment. Testing lipid nanoparticles for pre-eclampsia treatment.
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作者：Chen, Jie; Ou, Yuhui; Liu, Ying
作者单位：Peking University; Tsinghua University
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作者：[Anonymous]
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作者：Guo, Xiao-Lin; Wang, Yi-Ding; Liu, Yan-Jun; Chu, Lei; Zhu, Hua; Hu, Ye; Wu, Ren-Yan; Xie, Hong-Yu; Yu, Juan; Li, Shui-Ping; Xiong, Zhao-Yang; Li, Ruo-Yan; Ke, Fang; Chen, Lei; Chen, Guo-Qiang; Chen, Liang; Bai, Fan; Enver, Tariq; Li, Guo-Hong; Li, Huai-Fang; Hong, Deng-Li
作者单位：Shanghai Jiao Tong University; Tongji University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Institute of Biophysics, CAS; Peking University; Peking University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Hainan Medical University; Wuhan University; University of London; University College London; Shanghai Jiao Tong University
摘要：The maintenance of genomic integrity in rapidly proliferating cells is a substantial challenge during embryonic development(1-3). Although numerous cell-intrinsic mechanisms have been revealed(4-7), little is known about genome-protective effects and influences of developmental tissue microenvironments on tissue-forming cells. Here we show that fetal liver hepatocytes provide protection to haematopoietic stem and progenitor cell (HSPC) genomes. Lineage tracing and depletion in mice demonstrate...
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作者：Jiao, Chengzhi; Xie, Xiaoming; Hao, Chenyang; Chen, Liyang; Xie, Yuxin; Garg, Vanika; Zhao, Li; Wang, Zihao; Zhang, Yuqi; Li, Tian; Fu, Junjie; Chitikineni, Annapurna; Hou, Jian; Liu, Hongxia; Dwivedi, Girish; Liu, Xu; Jia, Jizeng; Mao, Long; Wang, Xiue; Appels, Rudi; Varshney, Rajeev K.; Guo, Weilong; Zhang, Xueyong
作者单位：Chinese Academy of Agricultural Sciences; Institute of Crop Sciences, CAAS; Nanjing Agricultural University; China Agricultural University; Murdoch University; Harry Perkins Institute of Medical Research; University of Western Australia; South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals Group; Fiona Stanley Hospital; La Trobe University; Department of Economic Development, Jobs, Transport & Resources
摘要：Wheat is the second largest food crop with a very good breeding system and pedigree record in China. Investigating the genomic footprints of wheat cultivars will unveil potential avenues for future breeding efforts(1,2). Here we report chromosome-level genome assemblies of 17 wheat cultivars that chronicle the breeding history of China. Comparative genomic analysis uncovered a wealth of structural rearrangements, identifying 249,976 structural variations with 49.03% (122,567) longer than 5 kb....
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作者：Gorski, Bartosz; Rein, Jonas; Norris, Samantha; Ji, Yanxin; McEuen, Paul L.; Lin, Song
作者单位：Cornell University; Cornell University; Cornell University
摘要：High-throughput experimentation (HTE) has accelerated academic and industrial chemical research in reaction development and drug discovery and has been broadly applied in many domains of organic chemistry(1,2). However, application of HTE in electrosynthesis-an enabling tool for chemical synthesis-has been limited by a dearth of suitable standardized reactors(3-7). Here we report the development of microelectronic devices, which are produced using standard nanofabrication techniques, to enable...
