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• Cryo-electron microscopy structures of human cone visual pigments AI翻译
  作者：Peng, Qi; Li, Jian; Jiang, Haihai; Cheng, Xinyu; Nag, Probal; Kleinau, Gunnar; Lamb, Trevor D.; Busche, Leon; Lu, Qiuyuan; Zhou, Sili; Liu, Yidi; Zhang, Yuting; Lv, Sijia; Wan, Shuangyan; Yang, Tingting; Chen, Yixiang; Zhang, Wei; Nan, Weiwei; Fu, Ying; Che, Tong; Li, Yanyan; Liao, Hongfei; Duan, Jingjing; Schapiro, Igor; Scheerer, Patrick; Zhang, Jin
  作者单位：Nanchang University; Dortmund University of Technology; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Australian National University; John Curtin School of Medical Research; Southern University of Science & Technology; Southern University of Science & Technology; Nanchang University; Hebrew University of Jerusalem
  摘要：Human trichromatic color vision relies on three cone opsins [long-, middle-, and short-wavelength-sensitive opsins (LWS-, MWS-, and SWS-opsins, respectively)], whereas scotopic rod vision is mediated by rhodopsin. Although the structure of rhodopsin was solved more than 20 years ago, cone opsin structures have been lacking. Here, we present cryo-electron microscopy structures of the three human cone opsins, each bound to a G protein and all-trans retinal in the presumed active state. All three...
• Big Ebola outbreak puts research spotlight on little-known virus AI翻译
  作者：Kupferschmidt, Kai
• Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania AI翻译
  作者：Reilly, Patrick F.; Rong, Stephen; Tejada-Martinez, Daniela; Miller, Samantha L.; Tjahjadi, Audrey; Liu, Chang; Akers, Jared; Pomer, Alysa; Prentice, Margaret E.; Merriwether, D. Andrew; Friedlaender, Francoise R.; Koki, George; Friedlaender, Jonathan S.; Reilly, Steven K.; Tucci, Serena
  作者单位：Yale University; Yale University; State University of New York (SUNY) System; Binghamton University, SUNY; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; PNG Institute Of Medical Research; Yale University; Thomas Jefferson University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Near Oceanic populations harbor substantial cultural, phenotypic, and genetic diversity yet are drastically underrepresented in human genomics. We generated 177 high-coverage Near Oceanian whole genomes and analyzed them alongside 1284 worldwide genomes, revealing major distinctions among and within islands, including long-term isolation and strong population bottlenecks. We reconstructed 1.897 billion base pairs of the archaic genome, including 831.9 million base pairs of Denisovan sequence, ...
• A unified platform for nucleoside analog synthesis AI翻译
  作者：Anketell, Matthew J.; Fung, Ethan; Liu, Wenbin; Shinde, Mahesh; He, Cyndi Qixin; Ng, Kurtis W. C.; Silverman, Steven M.; Campeau, Louis-Charles; Pantophlet, Ralph; Britton, Robert
  作者单位：Simon Fraser University; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Simon Fraser University; Merck & Company; Merck & Company USA
  摘要：Nucleoside analogs (NAs) are essential as antiviral and anticancer therapies. Despite decades of focused medicinal chemistry efforts, their related chemical space remains underexplored, mainly owing to their lengthy, single-molecule-oriented syntheses that lack the flexibility required to generate NA libraries. Here we report a flexible, robust, and efficient platform for the high-throughput synthesis of NAs using a photoredox coupling strategy. This approach produces both carbon- and nitrogen...
• AI-guided design of efficient perovskite solar cells operationally stable at 100°C AI翻译
  作者：Guo, Jiahao; Li, Bowei; Zhang, Zeyu; Liu, Fang; Li, Congyi; Wang, Yao; Wang, Shaowei; Chang, Guoqing; Fan, Junyi; Zhang, Taiyang; Lou, Yongbing; Wang, Shengnan; Cao, Xingzhong; Chen, Yuetian; Wang, Yanming; Miao, Yanfeng; Zhao, Yixin
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Institute of Technology; Southeast University - China; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of High Energy Physics, CAS
  摘要：Operationally stable perovskite solar cells (PSCs) have been sought after and debated since first being demonstrated. Here, we report a four-agent collaborative artificial intelligence (AI) to guide rational design of light absorbers, ultraviolet-resistant hole transport materials, and robust heterointerfaces for stable perovskite photovoltaics. Validated through thermodynamically driven single-crystal growth and thin-film experimental characterizations, the multiagent framework identified a h...
• Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide AI翻译
  作者：Klapars, Artis; Fryszkowska, Anna; Galanie, Stephanie; Ad, Omer; Aguilera, Ellen Y.; Akporji, Nnamdi; An, Chihui; Axnanda, Stephanus; Ayele, Tewoderos M.; Ayikpoe, Richard S.; Barrientos, Rodell C.; Bauerle, Matthew R.; Becker, Marc R.; Belyk, Kevin M.; Bereznitski, Lisa; Cahn, Jackson K. B.; Soto, Karla Camacho; Campeau, Louis-Charles; Campos, Kevin R.; Chandra, Anagha; Chang, Hsieh Yao Darryl; Chen, Mengbin; Chen, Zhiwei; Cheung-Lee, Wai Ling; Chung, Cheol K.; Chun, Stephanie W.; Co, Sarah S.; Cohen, Ryan D.; Dalby, Stephen M.; Dal Poggetto, Guilherme; Do, Truc; Dreher, Spencer D.; Drout, Riki J.; Dunham, Noah P.; Fan, Yi; Flessner, Ryan M.; Forstater, Jacob H.; France, Scott P.; Gamekkanda, Janaka C.; Gauthier, Donald R.; Gil, Agnieszka A.; Greenwood, Jacob W.; Ha, Noel; Halsey, Holst M.; Han, Xinxin; Hartmann, Michael; Hartmanshenn, Clara; He, Yu; Hernandez, Edgar; Hiraga, Kaori; Ho, Hsing-, I; Hong, Cynthia M.; Hruza, Alan; Hu, Hang; Hullen, Kari; Hyde, Alan M.; Itoh, Tetsuji; Jones, Chey M.; Jung, Woo-Ok; Kanuga, Kanan; Knippel, James Levi; Kolev, Joshua N.; Kong, Jongrock; Kosjek, Birgit; Koynov, Sara; Kress, Michael H.; Krishnamurthi, Bharath; Kuethe, Jeffrey T.; Kwok, Thomas T.; Lee, Alfred Y.; Lee, Joshua; Li, Qiuhan; Li, Shasha; Liao, Jing; Liu, Wenjun; Longia, Gurpreet; Madrigal, Emma; Maligres, Peter E.; Maloney, Kevin M.; McCarthy, Erin L.; McIntosh, John A.; Mesbahi-Vasey, Samaneh; Miller, Margaret; Modi, Mansi; Moore, Jeffrey C.; Mukherjee, Debopreeti; Murphy, Grant S.; Obligacion, Jennifer Victoriano; Pan, Weilan; Parzecki, Julia; Patel, Anisha; Peng, Teng; Peters, Byron K.; Piou, Tiffany; Pons Siepermann, Carlos A.; Prier, Christopher K.; Purohit, Akasha K.; Qin, Yangzhong; Regalado, Erik L.; Reibarkh, Mikhail; Rivera, Nelo R.; Robaire, Sandra A.; Robison, Lee; Roy, Syamantak; Ruck, Rebecca T.; Rykaczewski, Katie A.; Schuster, Christopher H.; Schwalm, Erica L.; Singh, Andrew N.; Sirota, Eric; Sun, Alexandra C.; Tang, Weijuan; Thaisrivongs, David A.; Thakur, Nimisha; Tong, Weidong; Truong, Van; Tsoi, Ryan; Tu, Qiang; Turnbull, Ben W. H.; Ukaegbu, Ophelia; Vargas, David A.; Velasquez, Juan E.; Verma, Deeptak; Wang, Heather; Wang, Tao; Wang, Xiao; Wang, Ying; Wang, Zhixun; Winston, Matthew S.; Wu, Chunyu; Wyvratt, Brian M.; Xiao, Kai-Jiong; Xu, Yingju; Yan, Jia-Xuan; Yang, Hao; Zhang, Victoria; Zhang, Yongqian; Zheng, Michelle; Zhong, Wendy
  作者单位：Merck & Company; Merck & Company; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA
  摘要：Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enlicitide for the treatment of atherosclerotic cardiovascular disease, are beginning to unlock these targets to orally administered therapies to enable broader patient access. We report the convergent biocatalytic assembly of enlicitide from simple building blocks enabled by a suite of engineered enz...
• Super-nano domains enable strength-conductivity synergy in copper foils AI翻译
  作者：Cheng, Zhao; Liu, Linhai; Yu, Zhiyang; Ye, Xiaoyuan; Tao, Nairong; Zhu, Ting; Lu, Lei
  作者单位：Chinese Academy of Sciences; Institute of Metal Research, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Fuzhou University; University System of Georgia; Georgia Institute of Technology
  摘要：The development of copper foils that simultaneously exhibit ultrahigh strength, high electrical conductivity, and thermal stability remains a major challenge for advanced electronics and energy storage systems. We report a 10-micrometer-thick copper foil featuring nanoscale grains and periodically distributed gradient super-nano domains (approximately 3 nanometers in size) throughout its thickness that was produced by an industrially scalable electrodeposition process. This copper foil demonst...
• Guidance of cellular nematic elastomers into shape-programmable living surfaces AI翻译
  作者：Guillamat, Pau; Mirza, Waleed; Bal, Pradeep K.; Gomez-Gonzalez, Manuel; Roca-Cusachs, Pere; Arroyo, Marino; Trepat, Xavier
  作者单位：University of Barcelona; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; European Molecular Biology Laboratory (EMBL); Universitat Politecnica de Catalunya; University of Barcelona; Universitat Politecnica de Catalunya; Centre Internacional de Metodes Numerics en Enginyeria (CIMNE); ICREA
  摘要：Engineering living materials that autonomously morph into predetermined shapes holds potential for synthetic morphogenesis and soft robotics. Harnessing cellular tissues to self-organize and generate forces offers a promising route toward this goal. However, controlling tissue mechanics to direct morphogenesis remains challenging. We introduce a strategy to program tissue-shape transformations through nematic organization of cellular forces. By controlling nematic order and topological defects...
• Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity AI翻译
  作者：Chung, Jooho; Vallurupalli, Mounica; Noel, Sarah; Schor, Gail; Mrowka, Sofia; Scapozza, Ilario; Demere, Zelalem; Kammula, Sachin V.; Hu, Margaret; Kim, Sarah Y.; Liu, YuhJong; Nobrega, Celeste; Perera, Jonathan J.; Wrona, Ewa; Cheruiyot, Collins K.; Lin, Yunkang; Wu, David W.; Saberi, Maria; Cruickshank, Aidan; Woods, Elliot C.; Chuong, Cun Lan; Birocchi, Filippo; Kammula, Ashwin V.; Avila, Omar I.; Knudsen, Nelson; Kocak, Mustafa; Doench, John G.; Procter, Dean; Thornton, Lindsey; Brunner, Andrew M.; Winer, Eric; DeAngelo, Daniel J.; Garcia, Jacqueline S.; Stone, Richard M.; Jenkins, Russell W.; Maus, Marcela V.; Graubert, Timothy A.; Yates, Kathleen B.; Golub, Todd R.; Manguso, Robert T.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Medical University Lodz; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Macrophages exert antitumorigenic activity through phagocytosis, but phagocytosis-enhancing therapeutics have not improved acute myeloid leukemia (AML) outcomes. To identify phagocytosis regulators, we performed CRISPR knockout screens in human AML cells cocultured with human macrophages. We found that the don't eat me signal CD47 inhibited mouse but not human macrophage phagocytosis. However, O-linked glycosylation and sialylation were strong negative regulators of phagocytosis. In AML, the c...
• A sensory system for mating in octopus AI翻译
  作者：Villar, Pablo S.; Jiang, Hao; Shugaeva, Tatiana; Berdan, Emma L.; Kulkarni, Arpita; Hiroi, Makoto; Masucci, Giovanni; Reiter, Sam; Lindahl, Erik; Howard, Rebecca J.; Hibbs, Ryan E.; Bellono, Nicholas W.
  作者单位：Harvard University; University of California System; University of California San Diego; Royal Institute of Technology; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard Medical School; Okinawa Institute of Science & Technology Graduate University; Stockholm University; Linkoping University; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Sensory systems for mate recognition maintain species boundaries and influence diversification. Thus, uncovering how molecules and receptors evolve to mediate this critical function is essential to understanding biodiversity. Male octopuses use a specialized arm called the hectocotylus to identify females and navigate their internal organs to reach the oviduct and deliver sperm. Here, we discovered that the hectocotylus is a dual sensory and mating organ that uses contact-dependent chemosensat...