Science

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• Circular 3D printing of high-performance photopolymers through dissociative network design AI翻译
  作者：Yang, Bo; Ni, Tiantian; Wu, Jingjun; Fang, Zizheng; Yang, Kexuan; He, Ben; Pu, Xingqun; Chen, Guancong; Ni, Chujun; Chen, Di; Zhao, Qian; Li, Wei; Li, Sujing; Li, Hao; Zheng, Ning; Xie, Tao
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：One approach for closed-loop plastics recycling relies on reverting polymers back into monomers because one can then make new plastics without loss of properties. This depolymerization requirement restricts the molecular design to making polymers with high mechanical performance. We report a three-dimensional (3D) printing chemistry through stepwise photopolymerization by forming dithioacetal bonds. The polymerized network can be transformed back into a photoreactive oligomer by dissociation o...
• Empower the age of smart mRNA medicine Programmable RNA sensor and molecular tools refine therapeutic payload production AI翻译
  作者：Gao, Xiaojing
  作者单位：Stanford University
• Clinical medicine AI翻译
  作者：Hu, Yutong
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
• Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans AI翻译
  作者：Wallis, Natalie J.; Mcclellan, Alyce; Morseburg, Alexander; Kentistou, Katherine A.; Jamaluddin, Aqfan; Dowsett, Georgina K. C.; Schofield, Ellen; Morros-Nuevo, Anna; Saeed, Sadia; Lam, Brian Y. H.; Sumanasekera, Natasha T.; Chan, Justine; Kumar, Sambhavi S.; Zhang, Rey M.; Wainwright, Jodie F.; Dittmann, Marie; Lakatos, Gabriella; Rainbow, Kara; Withers, David; Bounds, Rebecca; Ma, Marcella; German, Alexander J.; Ladlow, Jane; Sargan, David; Froguel, Philippe; Farooqi, I. Sadaf; Ong, Ken K.; Yeo, Giles S. H.; Tadross, John A.; Perry, John R. B.; Gorvin, Caroline M.; Raffan, Eleanor
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of Birmingham; University of Birmingham; University of Nottingham; University of Cambridge; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite de Lille; Pasteur Network; CNRS - National Institute for Biology (INSB); Institut Pasteur Lille; Universite de Lille; CHU Lille; Imperial College London; University of Liverpool; University of Liverpool; University of Cambridge; University of Cambridge
  摘要：Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score-a measure of obesity-in 241 Labrador retrievers. Using a cross-species approach, we showed that canine obesity genes are also associated with rare and common forms of obesity in humans. The lead canine association was within the gene DENN domain containing 1B (DENND1B). Each copy of th...
• Direct effects of mountain uplift and topography on biodiversity AI翻译
  作者：Marder, Eyal; Smiley, Tara M.; Yanites, Brian J.; Kravitz, Katherine
  作者单位：Indiana University System; Indiana University Bloomington; State University of New York (SUNY) System; Stony Brook University; University of Massachusetts System; University of Massachusetts Amherst
  摘要：Biodiversity hotspots in Earth's mountain ranges suggest a strong connection between topographic development and biological processes. However, it remains unclear whether high biodiversity in mountain ranges is an evolutionary response to the rate of relief generation during mountain building. Focusing on small mammals, such as rodents, we used coupled landscape-biological simulations to show that biodiversity increases with the magnitude and rate of tectonic uplift. This relationship, visible...
• TRUMP ADMINISTRATION Overseas universities see opportunity in US 'brain drain' AI翻译
  作者：Offord, Catherine
• G-quadruplex-stalled eukaryotic replisome structure reveals helical inchworm DNA translocation AI翻译
  作者：Batra, Sahil; Allwein, Benjamin; Kumar, Charanya; Devbhandari, Sujan; Bruening, Jan-Gert; Bahng, Soon; Lee, Chong M.; Marians, Kenneth J.; Hite, Richard K.; Remus, Dirk
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
  摘要：DNA G-quadruplexes (G4s) are non-B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork collisions with preformed G4s in the parental DNA using reconstituted yeast and human replisomes. We demonstrate that a single G4 in the leading strand template is sufficient to stall replisomes by arresting the CMG helicase. Cryo-electron microscopy structures of stalled yeast and human CMG compl...
• Tariffs imposed, scientists reinstated, peer review partly revived AI翻译
  作者：Brainard, Jeffrey
• #MeToo, not fraud, hits citations AI翻译
  作者：Brainard, Jeffrey
• 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions AI翻译
  作者：Lin, Jing-Ping; Brake, Alexis; Donadieu, Maxime; Lee, Amanda; Smith, Ginger; Hu, Kevin; Nair, Govind; Kawaguchi, Riki; Sati, Pascal; Geschwind, Daniel H.; Jacobson, Steven; Schafer, Dorothy P.; Reich, Daniel S.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Cedars Sinai Medical Center; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：Inferring cellular and molecular dynamics of multiple sclerosis (MS) lesions from postmortem tissue collected decades after onset is challenging. Using magnetic resonance image (MRI)-guided spatiotemporal RNA profiling in marmoset experimental autoimmune encephalitis (EAE), we mapped lesion dynamics and modeled molecular perturbations relevant to MS. Five distinct lesion microenvironments emerged, involving neuroglial responses, tissue destruction and repair, and brain border regulation. Befor...