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• Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N-heterocycles AI翻译
  作者：Ghosh, Bidhan; Kafle, Prakash; Mukherjee, Rishav; Welles, Randall; Herndon, Deacon; Nicholas, Kenneth M.; Shao, Yihan; Sharma, Indrajeet
  作者单位：University of Oklahoma System; University of Oklahoma - Norman
  摘要：Given the prevalence of nitrogen-containing heterocycles in commercial drugs, selectively incorporating a single nitrogen atom is a promising scaffold hopping approach to enhance chemical diversity in drug discovery libraries. We harness the distinct reactivity of sulfenylnitrenes, which insert a single nitrogen atom to transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, and triazines, respectively. Our additive-free method fo...
• Inherited genome instability AI翻译
  作者：Hehir-Kwa, Jayne Y.; Macintyre, Geoff
  作者单位：Princess Maxima Center; Centro Nacional de Investigaciones Oncologicas (CNIO)
• Coral records suggest global warming is strengthening El Nino AI翻译
  作者：Vaz, Julia
• Foreshock productivity and rupture nucleation in injection-induced earthquakes in western Canada AI翻译
  作者：Wang, Bei; Kao, Honn; Yu, Hongyu; Jiang, Yan; Lin, Qiang; Zhang, Wenli; Hua, Jun; Bai, Yushi; Chen, Zhilong; Zhang, Peng; Liu, Ya; Visser, Ryan
  作者单位：Zhejiang University of Technology; Zhejiang University; Zhejiang University; China Earthquake Administration; Institute of Geology, CEA
  摘要：Foreshock activity is a key consideration in traffic-light protocol (TLP) to mitigate seismic risk from injection-induced earthquakes (IIEs). However, the seismogenic processes of IIE foreshocks remain poorly understood. Using an enhanced western Canada catalog (2014-2024), we analyzed 77 IIE sequences to statistically delineate foreshock patterns before local magnitude (ML) >= 3 mainshocks. We found that 92% are preceded by foreshocks and that foreshock productivity and spatiotemporal pattern...
• MS Swaminathan: The Man Who Fed India AI翻译
  作者：Woolfson, Adrian
• A serendipitous sunset on Mars AI翻译
  作者：Fox, Paul L.
• Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion AI翻译
  作者：Glassman, Caleb R.; Baek, Kheewoong; Hou, Gaopeng; Zeng, Qiru; Nardone, Christopher; Juergens, Kate B.; Fujimura, Eric; O'Leary, Colin N.; Li, Mamie Z.; Paulo, Joao A.; Fischer, Eric S.; Ding, Siyuan; Harper, J. Wade; Elledge, Stephen J.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Washington University (WUSTL); Saint Louis University; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University; Harvard Medical School
  摘要：Viruses are intracellular parasites that reprogram the host proteome to promote replication and evade immune recognition. We applied a virome-wide library of similar to 10,000 open reading frames to discover viral ubiquitin ligases, mapping their mechanisms of degradation and host substrates using targeted CRISPR screens and proteomics. These viral effectors could be classified as canonical ligases that mimic host E3s, hijackers that redirect host E3s, and noncanonical ligases that rewire cull...
• Overcoming the performance ceiling of textured piezoelectric ceramics AI翻译
  作者：Zhang, Jinjing; Wang, Zidong; Yang, Shuai; Liu, Ruixuan; Chang, Jianglei; Wu, Haijun; Wang, Mingwen; Chen, Xiaoqing; Zhang, Yang; Zhou, Xianghong; Zhang, Chenbo; Daniels, John; Liu, Yuan-Jinsheng; Liu, Shi; Chang, Yunfei; Wang, Xianjie; Feng, Xinya; Li, Chunchun; Zhang, Nan; Li, Jinglei; Zhang, Shujun; Li, Fei
  作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong University; Tongji University; University of New South Wales Sydney; Westlake University; Harbin Institute of Technology; Harbin Institute of Technology; City University of Hong Kong
  摘要：Textured piezoelectric ceramics could deliver the ultrahigh piezoelectricity of single crystals while retaining the mechanical robustness and cost-effectiveness of conventional ceramics, but after decades of effort, their piezoelectricity has not approached that of single crystals. We exploited compositional flexibility of textured ceramics, a critical advantage over single-crystal counterparts, using a machine-learning approach. Our samarium (Sm)-doped Pb(In1/2Nb1/2)O3-Pb(Sc1/2Nb1/2)O3-PbTiO3...
• Curb plastic pollution at its source AI翻译
  作者：Rangel-Buitrago, Nelson
• A harrowing tour of Earth's sacrificial lands AI翻译
  作者：Sorkhabi, Rasoul
  作者单位：Utah System of Higher Education; University of Utah