Science

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• Too much of a good thing: Lessons from compromised rootworm Bt maize in the US Corn Belt AI翻译
  作者：Ye, Ziwei; Difonzo, Christina; Hennessy, David A.; Zhao, Jinhua; Wu, Felicia; Conley, Shawn P.; Gassmann, Aaron J.; Hodgson, Erin W.; Jensen, Bryan; Knodel, Janet J.; Mcmanus, Bradley; Meinke, Lance J.; Michel, Andrew; Potter, Bruce; Seiter, Nicholas J.; Smith, Jocelyn L.; Spencer, Joseph L.; Tilmon, Kelley J.; Wright, Robert J.; Krupke, Christian H.
  作者单位：Renmin University of China; Michigan State University; Iowa State University; Iowa State University; Cornell University; Michigan State University; Michigan State University; University of Wisconsin System; University of Wisconsin Madison; Iowa State University; University of Wisconsin System; University of Wisconsin Madison; North Dakota State University Fargo; South Dakota State University; University of Nebraska System; University of Nebraska Lincoln; University System of Ohio; Ohio State University; University of Minnesota System; University of Illinois System; University of Illinois Urbana-Champaign; University of Guelph; Illinois Natural History Survey; University of Illinois System; University of Illinois Urbana-Champaign; Purdue University System; Purdue University
  摘要：Widespread use of genetically engineered maize targeting the corn rootworm complex (Diabrotica species) has raised concerns about insect resistance. Twelve years of university field trial and farm survey data from 10 US Corn Belt states indicate that maize hybrids expressing toxins derived from the bacterium Bacillus thuringiensis (Bt maize) exhibited declining protection from rootworm feeding with increased planting while pest pressures simultaneously decreased. The analysis revealed a tenden...
• AGRICULTURE Crop research hit by US foreign aid freezes AI翻译
  作者：Charles, Dan; Stokstad, Erik
• The Moral Circle: Who Matters, What Matters, and Why AI翻译
  作者：Gellers, Joshua C.
  作者单位：State University System of Florida; University of North Florida
• Constrained roads to complex brains AI翻译
  作者：Gattoni, Giacomo; Tosches, Maria Antonietta
  作者单位：Columbia University
• Nutrient-driven histone code determines exhausted CD8+ T cell fates AI翻译
  作者：Ma, Shixin; Dahabieh, Michael S.; Mann, Thomas H.; Zhao, Steven; McDonald, Bryan; Song, Won-Suk; Chung, H. Kay; Farsakoglu, Yagmur; Garcia-Rivera, Lizmarie; Hoffmann, Filipe Araujo; Xu, Shihao; Du, Victor Y.; Chen, Dan; Furgiuele, Jesse; LaPorta, Michael A.; Jacobs, Emily; DeCamp, Lisa M.; Oswald, Brandon M.; Sheldon, Ryan D.; Ellis, Abigail E.; Liu, Longwei; He, Peixiang; Wang, Yingxiao; Jang, Cholsoon; Jones, Russell G.; Kaech, Susan M.
  作者单位：Salk Institute; Van Andel Institute; University of California System; University of California Irvine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Van Andel Institute; University of Southern California; University of California System; University of California San Diego
  摘要：Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control TEX differentiation remains unclear. We showed that TEX cells shifted from acetate to citrate metabolism by down-regulating acetyl-CoA synthetase 2 (ACSS2) while maintaining ATP-citrate lyase (ACLY) activity. This metabolic switch increased citrate-dependent histon...
• Randomizing the human genome by engineering recombination between repeat elements AI翻译
  作者：Koeppel, Jonas; Ferreira, Raphael; Vanderstichele, Thomas; Riedmayr, Lisa Maria; Peets, Elin Madli; Girling, Gareth; Weller, Juliane; Murat, Pierre; Liberante, Fabio Giuseppe; Ellis, Tom; Church, George McDonald; Parts, Leopold
  作者单位：Wellcome Trust Sanger Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Imperial College London; Harvard University; Harvard Medical School
  摘要：We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into repetitive sequences, up to 1697 per cell line, which enables generating large-scale deletions, inversions, translocations, and circular DNA. Recombinase induction produced more than 100 stochastic megabase-sized rearrangements in each cell. We tracked these rearrangements over time to measure selec...
• Herbicide tied to low birthweight AI翻译
  作者：Brainard, Jeffrey
• Misreported meals skew nutrition research data AI翻译
  作者：Offord, Catherine
• Quadruple-band synglisis enables high thermoelectric efficiency in earth-abundant tin sulfide crystals AI翻译
  作者：Liu, Shan; Bai, Shulin; Wen, Yi; Lou, Jing; Jiang, Yongzhen; Zhu, Yingcai; Liu, Dongrui; Li, Yichen; Shi, Haonan; Liu, Shibo; Wang, Lei; Zheng, Junqing; Zhao, Zhe; Qin, Yongxin; Liu, ZhongKai; Gao, Xiang; Qin, Bingchao; Chang, Cheng; Chang, Chao; Zhao, Li-Dong
  作者单位：Beihang University; Beihang University; Tianmushan Lab; ShanghaiTech University; Beihang University; Peking University
  摘要：Thermoelectrics have been limited by the scarcity of their constituent elements, especially telluride. The earth-abundant, wide-bandgap (E-g approximate to 46 k(B)T) tin sulfide (SnS) has shown promising performance in its crystal form. We improved the thermoelectric efficiency in SnS crystals by promoting the convergence of energy and momentum of four valance bands, termed quadruple-band synglisis. We introduced more Sn vacancies to activate quadruple-band synglisis and facilitate carrier tra...
• Diversity initiatives under fire AI翻译
  作者：Brainard, Jeffrey; Servick, Kelly