Science

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• Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations AI翻译
  作者：Huang, Huihui; Wang, Yi; Zsengeller, Zsuzsanna K.; Gorham, Joshua M.; Vemireddy, Vamsidhara; Clark, Amanda J.; Pan, Hui; Dreyfuss, Jonathan M.; Jotwani, Vasantha; Shlipak, Michael G.; Sarnak, Mark J.; Parikh, Chirag R.; Thiessen-Philbrook, Heather; Katz, Ronit; Waikar, Sushrut S.; Lake, Nicole J.; Lek, Monkol; Shi, Wen; Puiu, Daniela; Hong, Yun Soo; Seidman, Jonathan G.; Arking, Dan E.; Parikh, Samir M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; University of California System; University of California San Francisco; Tufts Medical Center; Johns Hopkins University; Johns Hopkins Medicine; University of Washington; University of Washington Seattle; Boston Medical Center; Boston University; Yale University; Johns Hopkins University; Johns Hopkins Medicine
  摘要：Somatically acquired mitochondrial DNA (mtDNA) mutations accumulate with age, but the mechanisms and consequences of this accumulation are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA mutations that impair resilience to future injuries. mtDNA mutations suppressed energy-intensive nucleotide metabolism. Repletion of adenosine, but not other nucleotides, restored adenosine triphosphate generation, which required a nuclear-encoded purine biosynthetic ...
• AI map reveals vast scope of 'ghost forests' along east coast of US AI翻译
  作者：Dinneen, James
• In a first, a gene therapy seems to slow Huntington disease AI翻译
  作者：Kaiser, Jocelyn
• Partisan disparities in the funding of science in the United States AI翻译
  作者：Furnas, Alexander C.; Fishman, Nic; Rosenstiel, Leah; Wang, Dashun
  作者单位：Northwestern University; Northwestern University; Northwestern University; Harvard University; Vanderbilt University; Northwestern University
• Differential absorption of circularly polarized light by a centrosymmetric crystal (vol 388, pg 1194, 2025) AI翻译
  作者：Parrish, K. A.
• Structure and function of a huge photosystem I-fucoxanthin chlorophyll supercomplex from a coccolithophore AI翻译
  作者：Shen, Lili; Ren, Fei; Wang, Yin-Chu; Li, Zhenhua; Zheng, Mengyuan; Li, Xiaoyi; Fan, Wenzheng; Yang, Yanyan; Sang, Min; Liu, Cheng; Han, Guangye; Qin, Song; Fan, Jianhua; Tian, Lijin; Kuang, Tingyun; Shen, Jian-Ren; Wang, Wenda
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Yantai Institute of Coastal Zone Research, CAS; Shihezi University; Okayama University
  摘要：Photosystem I (PSI) is a pigment-protein complex, which converts light energy into chemical energy in photosynthesis. Among photosynthetic organisms, PSI-LHC (light-harvesting complex) structures exhibit substantial differences in their sizes, reflecting adaptation to different light environments. Here we report the structure of a PSI-fucoxanthin chlorophyll a/c binding protein (FCPI) supercomplex from the coccolithophore Emiliania huxleyi (Eh) at 2.79-angstrom resolution by cryo-electron micr...
• Creating connection with wings and strings AI翻译
  作者：Elliott, Christine Harrison; Justus, Emily Jean
  作者单位：Purdue University System; Purdue University
• Linalool-triggered plant-soil feedback drives defense adaptation in dense maize plantings AI翻译
  作者：Guo, Dongsheng; Liu, Zilin; Raaijmakers, Jos M.; Xu, Yachun; Yang, Jinghui; Erb, Matthias; Zhang, Jiabao; Zhu, Yong-Guan; Xu, Jianming; Hu, Lingfei
  作者单位：Zhejiang University; Zhejiang University; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW); Leiden University; Leiden University - Excl LUMC; University of Bern; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Research Center for Eco-Environmental Sciences (RCEES), CAS
  摘要：High planting density boosts crop yields but also heightens pest and pathogen risks. How plants adapt their defenses under these conditions remains unclear. In this study, we reveal that maize enhances its defense in high-density conditions through a plant-soil feedback mechanism triggered by the leaf volatile linalool. Linalool activates jasmonate signaling in neighboring plants and promotes root exudation of benzoxazinoids, especially 2-(2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one)-beta-d-g...
• Observation of many-body dynamical localization AI翻译
  作者：Guo, Yanliang; Dhar, Sudipta; Yang, Ang; Chen, Zekai; Yao, Hepeng; Horvath, Milena; Ying, Lei; Landini, Manuele; Naegerl, Hanns-Christoph
  作者单位：University of Innsbruck; University of Innsbruck; Zhejiang University; Zhejiang University; University of Geneva
  摘要：The quantum kicked rotor is a paradigmatic model system in quantum physics. As a driven quantum system, it features dynamical localization, specifically Anderson localization in momentum space. However, the interacting many-body kicked rotor is believed to break localization. Here, we present evidence for many-body dynamical localization for the Lieb-Liniger version of the many-body quantum kicked rotor. After some initial evolution, the momentum distribution of interacting quantum-degenerate ...
• Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens AI翻译
  作者：Shenoy, Meera K.; Rico, Diane M.; Lorant, Alina K.; Toure, Hamadoun; Gordon, Shannon; Milburn, Luke J.; Schwensen, Jeanette S.; Caban, Madelyn E.; Koch, Meghan A.
  作者单位：Fred Hutchinson Cancer Center; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Maternal antibodies fundamentally regulate gut immunity in the developing infant, yet the mechanisms underlying this process remain elusive. We found that maternal immunoglobulin G (IgG), ingested in the first week of life, restrained microbiota-dependent adaptive immune responses weeks later, after weaning. This activity was linked to maternal antibodies that could bind bacteria in the neonatal gut and the ability of microbe-IgG complexes to engage Fc and complement-dependent effector functio...