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作者：Bencke, Glayson A.; Madeira, Marcelo M.; Perello, Luis F.; Velez-Martin, Eduardo; Mahler Jr, Jan Karel F.; Overbeck, Gerhard E.; Alves, Raphael V. Zulianello; Medeiros, Joao de Deus; Joner, Fernando
作者单位：Universidade Federal do Rio Grande do Sul; Universidade Federal de Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC)
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作者：Nguyen, Khue N. M.; Mo, Xueling; Demuynck, Bethany M.; Elsayed, Mohamed; Garwood, Jacob J. A.; Ngo, Duong T.; Rana, Ilias Khan; Nagib, David A.
作者单位：University System of Ohio; Ohio State University
摘要：Metal carbenes are highly useful intermediates in organic synthesis. However, not all classes of carbene polarity are catalytically accessible, nor are there common precursors known to synthesize all of these electronically diverse carbene types. Here, we report a unified strategy to access a full range of carbenes, including those with donor substituents (EDG: OMe, NR2, alkyl), acceptor substituents (EWG: CN, CO2R), and electronically neutral or nonpolar substituents (H, BR2, SiR3, halide, ar...
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作者：Wu, Jingying; Wang, Yafei; Li, Xiaoyu; Ouyang, Pei; Cai, Yuanyuan; He, Yang; Zhang, Mengyuan; Luan, Xinghua; Jin, Yuxiao; Wang, Jie; Xiao, Yujie; Liang, Yuqing; Xie, Fang; Shu, Yousheng; Hu, Jiong; Chang, Chunkang; Jiang, Jieling; Wu, Dong; Zhao, Youshan; Liu, Taohui; Li, Yuxin; Huang, Xiaojun; Li, Yao; Zhang, Junfang; Cao, Yuwen; Cheng, Xin; Mao, Ying; Rao, Yanxia; Cao, Li; Peng, Bo
作者单位：Shanghai Jiao Tong University; Fudan University; Fudan University; Fudan University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan University
摘要：Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and a fatal neurological disease without clinical cure. We developed mouse models harboring human hotspot mutations of CAMP and replaced CSF1R-deficient microglia with CSF1R-normal cells through microglia replacement by bone marrow transplantation ...
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作者：Bhattacharya, Ananyo
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作者：Lenormand, Thomas; Roze, Denis
作者单位：Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Sorbonne Universite
摘要：Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with homogametic offspring (Haldane's rule); and (iii) the X (or Z) has a disproportionately large effect on reproductive isolation between species compared with autosomes (the large X effect). Each observation has received its own tailored explanation invo...
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作者：Woolfson, Adrian
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作者：Qiang, Yi; Cao, Qiang; Xia, Liangjing; Chen, Yuquan; Wu, Xinyan; Chi, Hao
作者单位：Kunming University of Science & Technology; Hong Kong Baptist University; Monash University; Southwest Medical University
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作者：Chomicki, Guillaume; Metzler, Dirk; Naikatini, Alivereti; Renner, Susanne S.
作者单位：Durham University; University of Munich; University of the South Pacific; Washington University (WUSTL)
摘要：Many symbioses involve one host species having several mutualist partners, yet theory predicts that unrelated symbionts lead to destabilizing conflict through competition for host resources. We combined isotope labeling, computed-tomography three-dimensional models, behavioral field experiments, and mathematical models to show that Squamellaria plant hosts reduce conflict among their multiple ant symbiont species by offering nesting sites (domatia) divided into compartments with separate entra...
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作者：DiGiovanni, Laura F.; Khroud, Prabhsimran K.; Carmichael, Ruth E.; Schrader, Tina A.; Gill, Shivneet K.; Germain, Kyla; Jomphe, Robert Y.; Wiesinger, Christoph; Boutry, Maxime; Kamoshita, Maki; Snider, Daniel; Stubbings, Garret; Hua, Rong; Garber, Noel; Hacker, Christian; Rutenberg, Andrew D.; Melnyk, Roman A.; Berger, Johannes; Schrader, Michael; Raught, Brian; Kim, Peter K.
作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Exeter; University of Toronto; Hospital for Sick Children (SickKids); Medical University of Vienna; University of Osaka; Dalhousie University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; Kyung Hee University
摘要：Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmitochondrial antioxidant mechanisms is less well understood. We found a direct role for peroxisomes in maintaining mitochondrial redox homeostasis through contact-mediated reactive oxygen species (ROS) transfer. We found that ACBD5 and PTPIP51 form a contact between peroxisomes and mitochondria. The ...
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作者：Langin, Katie
