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• Redox-regulated Aux/IAA multimerization modulates auxin responses AI翻译
  作者：Roy, Dipan; Mehra, Poonam; Clark, Lisa; Mukkawar, Vaishnavi; Bellande, Kevin; Martin-Arevalillo, Raquel; Ghosh, Srayan; Ingole, Kishor D.; Bhagat, Prakash Kumar; Brown, Adrian; Sue-ob, Kawinnat; Jones, Andrew; Vermeer, Joop E. M.; Vernoux, Teva; Lilley, Kathryn; Mullineaux, Phil; Bechtold, Ulrike; Bennett, Malcolm J.; Sadanandom, Ari
  作者单位：Durham University; University of Nottingham; University of Neuchatel; Institut Agro; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); INRAE; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Institut National Polytechnique de Toulouse; University of Cambridge; University of Liverpool; University of Essex
  摘要：Reactive oxygen species (ROS) function as key signals in plant adaptation to environmental stresses, such as drought. Roots respond to transient water unavailability by temporarily ceasing branching through the acclimative response xerobranching. In this study, we report how a xerobranching stimulus triggers rapid changes of ROS levels in root nuclei, triggering redox-dependent multimerization of the auxin repressor protein IAA3. Mutations in specific cysteine residues of IAA3 disrupt redox-me...
• Molecular fossils show how life survived Snowball Earth AI翻译
  作者：Cutts, Elise
• Mapping the global coastal ocean with AI: Artificial neural networks can help better constrain the global carbon cycle in shallow seas AI翻译
  作者：Roobaert, Alizee
  作者单位：Flanders Marine Institute VLIZ; Universite Libre de Bruxelles
• Unraveling the emergent chorus of the mind: Machine learning reveals how a hidden neural code orchestrates diverse emotion states AI翻译
  作者：Nair, Aditya
  作者单位：California Institute of Technology
• Fruit fly studies mostly defy concerns about irreproducibility AI翻译
  作者：O'Grady, Cathleen
• Global earthquake detection and warning using Android phones AI翻译
  作者：Allen, Richard M.; Barski, Alexei; Berman, Micah; Bosch, Robert; Cho, Youngmin; Jiang, Xia Summer; Lee, Yun-Ling; Malkos, Steve; Mousavi, S. Mostafa; Robertson, Patrick; Spooner, Boone; Stogaitis, Marc; Thiruverahan, Nivetha; Wimpey, Greg
  作者单位：Alphabet Inc.; Google Incorporated; University of California System; University of California Berkeley; Harvard University; Alphabet Inc.; Google Incorporated
  摘要：Earthquake early-warning systems are increasingly being deployed as a strategy to reduce losses in earthquakes, but the regional seismic networks they require do not exist in many earthquake-prone countries. We use the global Android smartphone network to develop an earthquake detection capability, an alert delivery system, and a user feedback framework. Over 3 years of operation, the system detected an average of 312 earthquakes per month with magnitudes from M 1.9 to M 7.8 in Turkiye. Alerts...
• End looms for protein contest? AI翻译
  作者：Service, Robert F.
• Origins and diversity of Greenland's Qimmit revealed with genomes of ancient and modern sled dogs AI翻译
  作者：Feuerborn, T. R.; Appelt, M.; Bougiouri, K.; Bachmann, L.; Nielsen, I. Broman; Buckley, R. M.; Egevang, C.; Diaz-Maroto, P. Fernandez; Gopalakrishnan, S.; Gotfredsen, A. B.; Gregersen, K. M.; Gronnow, B.; Jensen, M. Lund; Madsen, C. K.; Markussen, U.; Midtdal, A.; Schmidt, A. L.; Armero, A. Serres; Vitale, E.; Wiig, O.; Zhang, G.; Dalen, L.; Frantz, L. A. F.; Gilbert, M. T. P.; Meldgaard, M.; Ostrander, E. A.; Sinding, M. -h. s.; Hansen, A. J.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Copenhagen; University of Copenhagen; Swedish Museum of Natural History; University of Copenhagen; University of Oslo; Zhejiang University; University of Copenhagen; Swedish Museum of Natural History; Stockholm University; University of Munich; University of Copenhagen
  摘要：The Qimmeq (Greenland sled dog) has worked continuously with the Inuit in Greenland for more than 800 years. However, they now face drastic population declines caused by climate change, urbanization, and competition from snowmobiles. This study sequenced 92 modern and ancient genomes to investigate how centuries of isolation shaped the regional Qimmeq populations and the impact of European contact. We found distinct regional populations and evidence for two migrations of dogs into Greenland wi...
• Integrated prostheses restore dynamic movement AI翻译
  作者：Fisher, Lee
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
• Human neuron subtype programming via single-cell transcriptome-coupled patterning screens AI翻译
  作者：Lin, Hsiu-Chuan; Janssens, Jasper; Eisinger, Benedikt; Hornauer, Philipp; Kroell, Ann-Sophie; Santel, Malgorzata; Pascual-Garcia, Maria; Okamoto, Ryoko; Karava, Kyriaki; He, Zhisong; Priouret, Marthe; Schroeter, Manuel; Camp, J. Gray; Treutlein, Barbara
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Roche Holding; University of Basel
  摘要：Human neurons programmed through transcription factor (TF) overexpression model neuronal differentiation and disease. However, the diversity of neuronal subtypes programmable in vitro remains unresolved. We modulated developmental signaling pathways combined with TF overexpression to explore the spectrum of neuron subtypes generated from pluripotent stem cells. We screened 480 morphogen signaling modulations coupled with TF induction using a multiplexed single-cell transcriptomic readout. Anal...