A single theory for the evolution of sex chromosomes and the two rules of speciation

• 成果类型: Article
• 署名作者: Lenormand, Thomas; Roze, Denis
• 署名单位: Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Sorbonne Universite
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12980
• DOI: 10.1126/science.ado9032
• 发表日期: 2025-07-10
• 关键词: dosage compensation complex; hybrid male-sterility; x-linked genes; haldanes rule; lethal complex; y-chromosome; drosophila-melanogaster; interspecific hybrids; postzygotic isolation; unisexual sterility

摘要

Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with homogametic offspring (Haldane's rule); and (iii) the X (or Z) has a disproportionately large effect on reproductive isolation between species compared with autosomes (the large X effect). Each observation has received its own tailored explanation involving multiple genetic and evolutionary causes. In this work, we show that these empirical patterns all emerge from a single theory for sex chromosome evolution incorporating the coevolution of cis- and trans-acting regulators of gene expression and leading to systematic misexpression of dosage-compensated genes in heterogametic F1 hybrids, for both young and old sex chromosomes.