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作者:Service, Robert F.
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作者:Sorrell, Erin M.; Kromm, Michelle; Gronvall, Gigi; Pekosz, Andrew; Davis, Meghan F.
作者单位:Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
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作者:Thorp, H. Holden
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作者:Yamamoto, Naoki; Wada, Kaito
作者单位:Keio University
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作者:Dumitru, Ionut; Paterlini, Marta; Zamboni, Margherita; Ziegenhain, Christoph; Giatrellis, Sarantis; Saghaleyni, Rasool; Bjoerklund, Asa; Alkass, Kanar; Tata, Mathew; Druid, Henrik; Sandberg, Rickard; Frisen, Jonas
作者单位:Karolinska Institutet; Chalmers University of Technology; Karolinska Institutet; Karolinska Institutet; Cancer Research UK
摘要:Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated. We analyzed the human hippocampus from birth through adulthood by single-nucleus RNA sequencing. We identified all neural progenitor cell stages in early childhood. In adults, using antibodies against the proliferation marker Ki67 and machine lea...
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作者:Koptekin, Dilek; Aydogan, Ayca; Karamurat, Cansu; Altinisik, N. Ezgi; Vural, Kivilcim Basak; Kazanci, D. Deniz; Dogu, Ayca Kucukakdag; Kaptan, Damla; Gemici, Hasan Can; Yuncu, Eren; Moots, Hannah M.; Umurtak, Gulsun; Duru, Refik; Fidan, Erkan; Cevik, Ozlem; Erdogu, Burcin; Korkut, Taner; Knusel, Christopher J.; Haddow, Scott; Larsen, Clark Spencer; Ozbal, Rana; Gerritsen, Fokke; Ozdogan, Eylem; Akbaba, Ali; Usanmaz, Uygar Ozan; Derici, Yasin Cemre; Ucmazoglu, Mine; Jay, Flora; Ozdogan, Mehmet; Gotherstrom, Anders; Erdal, Yilmaz Selim; Malaspinas, Anna-Sapfo; Atakuman, Cigdem; Ozer, Fusun; Somel, Mehmet
作者单位:Middle East Technical University; Middle East Technical University; University of Lausanne; Swiss Institute of Bioinformatics; University of Lausanne; Hacettepe University; Middle East Technical University; Swedish Museum of Natural History; Istanbul University; Bilecik Seyh Edebali University; Trakya University; Akdeniz University; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Copenhagen; University System of Ohio; Ohio State University; Koc University; Netherlands Institute in Turkey; Leiden University; Leiden University - Excl LUMC; Istanbul University; Mus Alparslan University; Inria; Microsoft; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Middle East Technical University
摘要:West Anatolia has been a crucial yet elusive element in the Neolithic expansion from the Fertile Crescent to Europe. In this work, we describe the changing genetic and cultural landscapes of early Holocene West Anatolia using 30 new paleogenomes. We show that Neolithization in West Anatolia was a multifaceted process, characterized by the assimilation of Neolithic practices by local foragers, the influx of eastern populations, and their admixture, with their descendants subsequently establishi...
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作者:Metheringham, Carey L.; Plumb, William J.; Flynn, William R. M.; Stocks, Jonathan J.; Kelly, Laura J.; Gorriz, Miguel Nemesio; Grieve, Stuart W. D.; Moat, Justin; Lines, Emily R.; Buggs, Richard J. A.; Nichols, Richard A.
作者单位:University of London; Queen Mary University London; Royal Botanic Gardens, Kew; Teagasc; University of London; Queen Mary University London; University of Cambridge; University of London; Queen Mary University London; University of Cambridge; University of Dundee; Syngenta
摘要:Rapid evolution through small shifts in allele frequencies at thousands of loci is a long-standing neo-Darwinian prediction but is hard to characterize in the wild. European ash tree (Fraxinus excelsior) populations have recently come under strong selection by the invasive fungal pathogen Hymenoscyphus fraxineus. Using genomic prediction models based on field trial phenotypes and 7985 loci, we show a shift in genomically estimated breeding values in an ancient woodland, between adult trees est...
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作者:Offord, Catherine
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作者:Verschuur, Jasper; Ranger, Nicola; Hall, Jim. W.
作者单位:Delft University of Technology; Delft University of Technology; University of Oxford; University of London; London School Economics & Political Science
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作者:Ikegami, Shin; Takeda, Yusuke; Mutterlose, Joerg; Iba, Yasuhiro
作者单位:Hokkaido University; Japan Synchrotron Radiation Research Institute; Ruhr University Bochum
摘要:The evolution of soft-bodied squids, which provide a major part of the biomass in modern oceans globally, is poorly understood owing to their patchy fossil record. We provide a comprehensive evolutionary history of squids through digital fossil-mining techniques, revealing a new lagerst & auml;tte. The more than 250 fossil beaks of 40 species show that squids originated and rapidly radiated by 100 million years ago. Our data suggest that the radical shift from heavily shelled, slowly moving ce...