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• Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression AI翻译
  作者：Bianchi, Danielle; Borza, Razvan; De Zan, Erica; Huelsz-Prince, Guizela; Gregoricchio, Sebastian; Dekker, Marleen; Fish, Alex; Mazouzi, Abdelghani; Kroese, Lona J.; Linder, Simon; Hernandez-Quiles, Miguel; Vermeulen, Michiel; Celie, Patrick H. N.; Krimpenfort, Paul; Song, Ji-Ying; Zwart, Wilbert; Wessels, Lodewyk; Nijman, Sebastian M. B.; Perrakis, Anastassis; Brummelkamp, Thijn R.
  作者单位：Netherlands Cancer Institute; University of Oxford; Ludwig Institute for Cancer Research; University of Oxford; Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Radboud University Nijmegen; Netherlands Cancer Institute
  摘要：Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting of QRICH1 and SEPHS1, as a ZNF-specific coregulator essential for embryonic development in mice and associated with developmental syndromes in humans. We also identified ZFP91 as a representative Zincore client, binding the conserved promoter motif CTTTAAR. Cryo-electron microscopy of a Zincore-ZFP...
• Ferroelectric materials toward next-generation electromechanical technologies AI翻译
  作者：Li, Fei; Wang, Bo; Gao, Xiangyu; Damjanovic, Dragan; Chen, Long-Qing; Zhang, Shujun
  作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong University; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Wollongong
  摘要：Ferroelectric materials have been widely used in various electromechanical devices, from ultrasonic transducers and actuators to mechanical energy harvesters. The key performance metrics of these devices, such as sensitivity, efficiency, and bandwidth of ultrasonic transducers, are largely determined by the piezoelectric properties. This Review highlights recent research progress in improving the piezoelectricity of ferroelectric materials and offers potential strategies for further enhancemen...
• A tighter grip on gene expression AI翻译
  作者：Nemcko, Filip; Stark, Alexander
  作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Vienna Biocenter (VBC); Medical University of Vienna
  摘要：A previously unknown cofactor function stabilizes transcription factor binding across the genome
• Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition AI翻译
  作者：Petzold, Georg; Gainza, Pablo; Annunziato, Stefano; Lamberto, Ilaria; Trenh, Peter; McAllister, Laura A.; DeMarco, Bradley; Schwander, Laura; Bunker, Richard D.; Zlotosch, Mary; Sriramaratnam, Rohitha; Gilberto, Samuel; Langousis, Gerasimos; Donckele, Etienne J.; Quan, Chao; Strande, Vaik; De Donatis, Gian Marco; Alabi, Shanique B.; Alers, Jessica; Matysik, Michelle; Staehly, Camille; Dubois, Aurelie; Osmont, Arnaud; Garskovas, Mackenzie; Lyon, David; Wiedmer, Lars; Oleinikovas, Vladimiras; Lieberherr, Raphael; Rubin, Nooreen T.; Lam, Daniel T.; Lucas, Xavier; Liardo, Elisa; Widlund, Nina Ilic; Ritzen, Andreas; Caceres, Ramon Miguel; Vigil, Dominico; Tsai, Jennifer; Wallace, Owen; Peluso, Marisa; Sadok, Amine; Tiedt, Ralph; Paterson, Alison M.; Zarayskiy, Vladislav; Fasching, Bernhard; Bonenfant, Debora; Warmuth, Markus; Castle, John C.; Townson, Sharon A.
  摘要：The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cereblon (CRBN) neosubstrates share a generalizable beta-hairpin G-loop recognition motif that allows for the systematic exploration of the CRBN target space. Computational mining approaches using structure- and surface-based matchmaking algorithms predict more than 1600 CRBN-compatible G-loop protein...
• Left behind AI翻译
  作者：Cohen, Jon
• Electric double-layer synthesis of a spongelike, lightweight reticular membrane AI翻译
  作者：Itoh, Yoshimitsu; Fu, Tengfei; Champagne, Pier-Luc; Yokoyama, Yudai; Numabe, Kunita; Hong, You-lee; Nishiyama, Yusuke; Wang, Hsiao-Fang; Kumagai, Akemi; Jinnai, Hiroshi; Watanabe, Hirohmi; Shibata-Seki, Teiko; Nagao, Asuteka; Suzuki, Tsutomu; Saito, Yukie; Wakabayashi, Keigo; Yoshii, Takeharu; Izumi, Atsushi; Hagita, Katsumi; Furukawa, Junichi; Aida, Takuzo
  作者单位：University of Tokyo; Japan Science & Technology Agency (JST); RIKEN; RIKEN; Jeol Ltd; Tohoku University; National Institute of Advanced Industrial Science & Technology (AIST); University of Tokyo; National Defense Academy - Japan; RIKEN; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; National Central University; KAO Corporation
  摘要：Electrochemical polymer synthesis usually forms dense films bound to the electrode. We report a single-step synthesis of large-area, ultrathin (similar to 70-nanometer) polymeric membranes with a luffa-like, reticular cross-linked network with low density (0.5 grams per cubic centimeter). This particular membrane forms within an electric double layer in water constructed by voltage application without supporting electrolytes-in which deprotonated resorcinol and an aldehyde react three-dimensio...
• The vaccine we all wear: Skin microbiota can be engineered into topical vaccines AI翻译
  作者：Bousbaine, Djenet
  作者单位：Stanford University
• Fluorine-free strongly dipolar polymers exhibit tunable ferroelectricity AI翻译
  作者：Huang, Jiahao; Rui, Guanchun; Yan, Yueming; Allahyarov, Elshad; Kwok, Man-Hin; Zhu, Wenyi; Li, Li; Zhang, Shixian; Pan, Zhiliang; Li, Deyu; Zhang, Honghu; Mu, Richard R.; Zhao, Bin; Wang, Qing; Taylor, Philip L.; Haglund, Richard F.; Zhang, Q. M.; Zhu, Lei
  作者单位：University System of Ohio; Case Western Reserve University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Arkema; Vanderbilt University; Heinrich Heine University Dusseldorf; Russian Academy of Sciences; Joint Institute for High Temperatures of the Russian Academy of Sciences; University System of Ohio; Case Western Reserve University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Vanderbilt University; United States Department of Energy (DOE); Brookhaven National Laboratory; Tennessee State University; University of Tennessee System; University of Tennessee Knoxville; Chinese University of Hong Kong
  摘要：Current research on ferroelectric polymers centers predominantly on poly(vinylidene fluoride) (PVDF)-based fluoropolymers because of their superior performance. However, they are considered forever chemicals with environmental concerns. We describe a family of rationally designed fluorine-free ferroelectric polymers, featuring a polyoxypropylene main chain and disulfonyl alkyl side chains with a C3 spacer: -SO2CH2CHRCH2SO2- (R = -H or -CH3). Both experimental and simulation results demonstrate...
• The intracellular Ca2+ sensitivity of transmitter release in glutamatergic neocortical boutons AI翻译
  作者：Bornschein, Grit; Brachtendorf, Simone; Reinert, Anja; Eshra, Abdelmoneim; Kraft, Robert; Hirrlinger, Johannes; Eilers, Jens; Hallermann, Stefan; Schmidt, Hartmut
  作者单位：Leipzig University
  摘要：Synaptotagmin-1 (Syt1) and Syt2 are the main calcium (Ca2+) sensors triggering synchronous release in the brain. In this work, we studied the mechanisms mediating Syt1-triggered release from neocortical synapses. We measured the Ca2+ dependency of release in layer 5 pyramidal neuron synapses by laser photolysis of caged Ca2+. Release had high Ca2+ affinity and positive cooperativity. Measurements at cerebellar Purkinje cell synapses and kinetic models indicate substantial differences compared ...
• The gut microbiome-germline axis: Does a prospective father's gut microbiota matter? AI翻译
  作者：Argaw-Denboba, Ayele
  作者单位：Max Planck Society