Proceedings of the National Academy of Sciences of the United States of America

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• Hidden domain boundary dynamics toward crystalline perfection AI翻译
  作者：Mangu, Anudeep; Stoica, Vladimir A.; Zheng, Hao; Yang, Tiannan; Zhang, Maohua; Wang, Huaiyu (Hugo); Zu, Rui; Nguyen, Quynh L.; Song, Sanghoon; Das, Sujit; Meisenheimer, Peter; Donoway, Elizabeth; Chollet, Matthieu; Sun, Yanwen; Turner, Joshua J.; Freeland, John W.; Wen, Haidan; Martin, Lane W.; Chen, Long-Qing; Gopalan, Venkatraman; Zhu, Diling; Cao, Yue; Lindenberg, Aaron M.
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Indian Institute of Science (IISC) - Bangalore; University of California System; University of California Berkeley; Rice University; Rice University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：A central paradigm of nonequilibrium physics concerns the dynamics of heterogeneity and disorder, impacting processes ranging from the behavior of glasses to the emergent functionality of active matter. Understanding these complex mesoscopic systems requires probing the microscopic trajectories associated with irreversible processes, the role of fluctuations and entropy growth, and the timescales on which nonequilibrium responses are ultimately maintained. Approaches that illuminate these proc...
• Moisture- driven carbonation kinetics for ultrafast CO2 mineralization AI翻译
  作者：Gao, Yining; Tao, Yong; Li, Gen; Shen, Peiliang; Pellenq, Roland J. M.; Poon, Chi Sun
  作者单位：Hong Kong Polytechnic University; Hong Kong Polytechnic University; Ecole nationale superieure de chimie de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite de Montpellier
  摘要：CO2 mineralization, a process where CO2 reacts with minerals to form stable carbonates, presents a sustainable approach for CO2 sequestration and mitigation of global warming. While the crucial role of water in regulating CO2 mineralization efficiency is widely acknowledged, a comprehensive understanding of the underlying mechanisms remains elusive. This study employs a combined experimental and atomistic simulation approach to elucidate the intricate mechanisms governing moisture- driven carb...
• Complex tissue regeneration in Lophuromys reveals a phylogenetic signal for enhanced regenerative in rodents AI翻译
  作者：Riddell, Brennan; Mcdonough, Molly; Ferguson, Adam; Kimani, John M.; Gawriluk, Thomas R.; Peng, Chi; Kiama, Stephen G.; Ezenwa, Vanessa O.; Seifert, Ashley W.
  作者单位：University of Kentucky; Chicago State University; Field Museum of Natural History (Chicago); University of Nairobi; University of Kentucky; Yale University
  摘要：Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, and tissue physiology that explain how regenerative healing emerges in some species requires sampling...
• Salmonella infection accelerates postnatal maturation of the intestinal epithelium AI翻译
  作者：Schloesser, Stefan; Ullrich, Anna-Lena; Modares, Nastaran Fazel; Schmitz, Matthias A.; Schoeneich, Johannes; Zhang, Kaiyi; Richter, Isabel; Robrahn, Laura; Schraven, Sarah; Nagai, James S.; Haange, Sven-Bastiaan; Jennings, Susan A. V.; Clavel, Thomas; Rolle-Kampczyk, Ulrike; Kiessling, Fabian; Costa, Ivan G.; Muncan, Vanesa; Repnik, Urska; von Bergen, Martin; Dupont, Aline; Hornef, Mathias W.
  作者单位：RWTH Aachen University; RWTH Aachen University Hospital; Hannover Medical School; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; University of Kiel; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
  摘要：Postnatal establishment of enteric metabolic, host-microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infection with the invasive enteropathogen Salmonella Typhimurium results in accelerated maturation of the neonatal epithelium with premature appearance of antimicrobial, metabolic, developmental, and regenerative features of the adult tissue. Using conditional Myd88- deficient mice, we identify the c...
• A genome-wide microRNA screen identifies the microRNA- 183/96/182 cluster as a modulator of circadian rhythms ( vol 118 , e2020454118 , 2020) AI翻译
  作者：Zhou, Lili; Miller, Caitlyn; Miraglia, Loren J.; Romero, Angelica; Xu, Shunbin; Mure, Ludovic S.; Panda, Satchidananda; Kay, Steve A.
  作者单位：University of Southern California; Novartis; Novartis USA; Wayne State University; Salk Institute
• Genetic dissection of nonconventional introns reveals codominant noncanonical splicing code in Euglena AI翻译
  作者：Nomura, Toshihisa; Kim, June - Sik; Iwata, Osamu; Yamada, Koji; Atsuji, Kohei; Uehara-Yamaguchi, Yukiko; Yoshida, Takuhiro; Inoue, Komaki; Takahagi, Kotaro; Sakurai, Tetsuya; Shinozaki, Kazuo; Ito, Takuro; Suzuki, Kengo; Goda, Keisuke; Mochida, Keiichi
  作者单位：RIKEN; RIKEN; Yamagata University; Okayama University; Yokohama City University; Kochi University; University of Tokyo; Wuhan University; University of California System; University of California Los Angeles; Tohoku University; Nagasaki University
  摘要：Pre-mRNA splicing is essential for eukaryotic gene expression and is achieved through the accurate recognition of exon-intron boundaries. Although nonconventional introns, which do not follow the conventional GT-AG splicing rule, have been identified in several species, these introns are typically rare in any given genome. Here, we demonstrate the widespread occurrence of nonconventional introns (71.8% of all introns) in the Euglena agilis genome and identify consensus motifs at these nonconve...
• Designers join scientists to make living architecture a reality AI翻译
  作者：Beans, Carolyn
• Heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals and low- density Cx36 gap junctions AI翻译
  作者：Pourhosseinzadeh, Mohammad S.; Huang, Jessica L.; Shin, Donghan; Hart, Ryan G.; Framroze, Luhaiza Y.; Guillen, Jaresley, V; Sanchez, Joel; Tirado, Ramir, V; Unanwa, Kelechi; Huising, Mark O.
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Insulin potently decreases blood glucose; thus, tight control is required to prevent excessive insulin release and hypoglycemia. Central to this inhibition is somatostatin released from delta cells that are clustered with beta cells in pancreatic islets. This communication is of interest because the loss of functional beta cells in diabetes leads to uncontrolled delta cell activity that disrupts islet paracrine crosstalk. While it is established that insulin and somatostatin secretion are coor...
• Probing the connection between chirality and spin through time- resolved EPR spectroscopy AI翻译
  作者：Saxena, Sunil; Waldeck, David H.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
• Drosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration AI翻译
  作者：Stanhope, Sarah C.; Singhal, Kratika; Morato, Nicolas M.; Feng, Yunfei; Meng, Gaoya; Marlin, Makayla N.; Kotanko, Claudia C.; Jarrett, Madolyn M.; Mesecar, Andrew D.; Cooks, R. Graham; Weake, Vikki M.
  作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：One- carbon metabolism influences gene expression by providing methyl units for DNA, RNA, and histone methylation. Robust methylation requires rapid hydrolysis of the (Ahcy). Ahcy is essential for maintaining methylation potential; however, the mechanisms governing its enzymatic activity, particularly in response to cellular stress, remain largely uncharacterized. Here, we show Ahcy is a redox- sensitive enzyme that is inhibited by oxidation of a conserved cysteine, C195, in vitro resulting in...