Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Cosmic ray-driven electron-induced reaction theory quantifies spatiotemporal variations in lower-stratospheric ozone and temperature AI翻译
  作者：Lu, Qing- Bin
  作者单位：University of Waterloo; University of Waterloo; University of Waterloo
  摘要：Cosmic rays (CRs) play an important role in affecting planetary and interstellar climate and environment. Here, we apply the CR-driven electron-induced reaction (CRE) theory of ozone depletion to obtain a quantitative understanding of spatiotemporal variations in Earth's lower-stratospheric ozone (LSO) and temperature, which provide fingerprints for the mechanisms of ozone depletion and examine the impact of nonhalogen greenhouse gases on the ozone layer. We first show from observations that b...
• A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression AI翻译
  作者：Wang, Yubao; Manokaran, Cherubin; Huang, Kevin; Schaffhausen, Brian; Roberts, Thomas M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Tufts University
  摘要：The study of DNA tumor viruses has revolutionized cancer biology, partly by virtue of the unique capabilities of viral oncoproteins to manipulate key proteins and pathways involved in tumorigenesis. We find a high affinity and selective binding of the polyoma small T antigen (PyST) with the transcription cofactor TAZ. engineering a degradable version of PyST, we demonstrate that, when TAZ activity is modulated by PyST, a surprisingly small number of genes have altered expression and thus are c...
• The effects of social media criticism against public health institutions on trust, emotions, and social media engagement AI翻译
  作者：Lee, Jonathan Y.
  作者单位：Stanford University
  摘要：In recent years, trust in US public health and science institutions has faced unprecedented declines, particularly among Republicans/conservatives. To what extent might institutional criticism on social media be responsible for such politically polarized declines in institutional trust? Two online survey experiments (total N = 6,800), using samples roughly reflective of the US adult population, examined the effects of key types of criticism against the Agency for Healthcare Research and Qualit...
• Women climate scientists are connected, productive, and successful but have shorter careers AI翻译
  作者：Martin, Chris C.; Lockley, Andrew; Hendricks, Steve; Clark, Cory J.; Mundra, Ishita; Matzner, Nils
  作者单位：University System of Georgia; Georgia Institute of Technology; University of Pennsylvania; University of Washington; University of Washington Seattle; Technical University of Munich; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ)
  摘要：Scholars have long been concerned about gender representation in scientific research but there has been little work on gender differences in participation and performance in climate science, a field that engages with both male-majority disciplines (e.g., geosciences, engineering) and female-majority disciplines (e.g., life sciences, medical science). This has implications for both gender equity and viewpoint representation. Sampling over 400,000 publications and a similar number of authors, we...
• A twist grain boundary phase in aqueous solutions of the nucleic acid tetramer GTAC (vol 122, e2416142122, 2025) AI翻译
  作者：Smitha, Gregory P.; Zhub, Chenhui; Zhernenkovc, Mikhail; Freychetd, Guillaume; Clarka, Noel A.; Zhernenkov, Mikhail; Freychet, Guillaume; Clark, Noel A.
  作者单位：University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory; CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
• Reply to Hirbo et al.: The need for large- scale family cohorts and robust analytical frameworks of postexome study AI翻译
  作者：Wu, Xin- Rui; Yang, Liu; Wu, Bang- Sheng; Cheng, Wei; Yu, Jin- Tai
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
• Increased sea-level contribution from northwestern Greenland for models that reproduce observations AI翻译
  作者：Badgeley, Jessica A.; Morlighem, Mathieu; Seroussi, Helene
  作者单位：Dartmouth College; Dartmouth College
  摘要：State-of-the-art ice sheet model simulations used in the Ice Sheet Model Intercomparison Project (ISMIP) that informs the Intergovernmental Panel on Climate Change tend to underestimate observed mass loss from the Greenland Ice Sheet, leading to the question of whether future sea-level rise may be larger than projected. We use one of these models, the Ice-sheet and Sea-level System Model, to investigate how transient calibration impacts historical and projection simulations. Transient calibrat...
• The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant AI翻译
  作者：Gonzalez-Delgado, Javier; Mier, Pablo; Bernado, Pau; Neuvial, Pierre; Cortes, Juan
  作者单位：Universite de Rennes; Ecole Nationale de la Statistique et de l'Analyse de l'Information (ENSAI); Centre National de la Recherche Scientifique (CNRS); Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Centre National de la Recherche Scientifique (CNRS)
  摘要：The correlation between synonymous codon usage and secondary structure in translated proteins has been widely demonstrated. This usage plays a capital role in tuning translational rates and protein folding kinetics, indirectly influencing multiple Nat. Commun. 13, 2815 (2022).] suggests that the translated synonymous codon influences the (tp, ) dihedral angles within secondary structure elements. If true, this conclusion would have strong consequences in several scientific fields, including st...
• The CARD14sh-BCL10-MALT 1 complex regulates MAVS- mediated antiviral response in keratinocytes AI翻译
  作者：Zerillo, Lucrezia; Zotti, Tiziana; Tutela, Angelapia; Madera, Jessica Raffaella; Grasso, Gabriella; Vito, Pasquale; Stilo, Romania
  作者单位：University of Sannio
  摘要：The Mitochondrial Antiviral Signaling Protein (MAVS) is a key adaptor in antiviral immunity, mediating type I interferon responses downstream of RIG1 and TLR3. While MAVS regulation is essential for antiviral defense, its modulation in keratinocytes is poorly understood. Here, we examine the role of the CARD14-BCL10-MALT1 (CBM) complex, a skin-specific signaling module, in controlling MAVS-dependent antiviral responses. We identify CARD14short as a dual regulator that activates NF-kappa B whil...
• A unifying principle for multispecies coexistence under resource fluctuations AI翻译
  作者：Richardson, James A.; Engelstaedter, Jan; Letten, Andrew D.
  作者单位：University of Queensland
  摘要：Resource fluctuations are ubiquitous in nature and yet are generally assumed to play a limited role in the maintenance of biodiversity. We challenge this assumption by analyzing resource competition dynamics under conditions where prevailing theory does not hold. We show that multispecies coexistence can be sustained when species are able to specialize on different temporal patterns of resource variability, including the asymmetries and periodic extremes commonly observed in natural systems. W...