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作者：Wang, Qiuyi; Wang, Yue; Lin, Yujie; Zhou, Jiawen; Mao, Zhiyuan; Gu, Xin; Chen, Haiyun; Li, Jiyu; Chen, Ao; Zhang, Jin'ge; Wang, Rong; Zhao, Yingming; Gu, Mufeng; Li, Qing; Zhang, Yongjie; Jin, Jianliang
作者单位：Nanjing Medical University; Jiangnan University; Nanjing University
摘要：New immunosenescence targets for preventing senescence-associated pathological cardiac hypertrophy (SA-PCH) need to be explored. In the present study, with physiologically aged human and mouse samples, the IL-17A level increased with physiological aging, heart failure (HF), and SA-PCH and was negatively correlated with thymic Bmi-1 expression. Bmi-1f/fLckCre+ mice and Bmi-1f/flittermates were generated to determine whether Bmi-1 delayed T cell aging by maintaining thymic T cell development to ...
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作者：Khanra, Nandish K.; Wang, Chongyuan; Delgado, Bryce D.; Long, Stephen B.
作者单位：Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Roche Holding; Roche Holding USA; Genentech
摘要：The potassium channel TWIK-2 is crucial for ATP-induced activation of the NLRP3 inflammasome in macrophages. The channel is a member of the two-pore domain potassium (K2P) channel superfamily and an emerging therapeutic target to mitigate severe inflammatory injury involving NLRP3 activation. We report the cryo-EM structure human TWIK-2. In comparison to other K2P channels, the structure reveals an unusual up conformation of Tyr111 in the selectivity filter and a resulting SF1-P1 pocket behind...
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作者：Han, Jinling; Zhang, Meichen; Ge, Jiakun; Ji, Zhihua; Zhao, Jianyi; Hu, Yinchao; Li, Chunshuang; Xue, Yaoyao; Li, Xining; Zhao, Haiwang; Cui, Zixu; Tian, Miaomiao; Zheng, Xu; Wang, Dapeng; Wang, Jing; Wei, Min; Radak, Zsolt; Nakabeppu, Yusaku; Boldogh, Istvan; Ba, Xueqing
作者单位：Northeast Normal University - China; Northeast Normal University - China; Jilin University; Jiangnan University; Nanjing Medical University; University of Physical Education; Kyushu University; University of Texas System; University of Texas Medical Branch Galveston
摘要：8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant hOGG1S326C, prevalent in Caucasians and Asians, has been regarded as a susceptibility factor for various diseases, yet its pathogenic mechanism remains elusive. In this study, we demonstrate that Ogg1S326C/S326Cmice exhibit increased and sustained airway inflammati...
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作者：Lee, Geon; Choi, Wonjae; Seung, Hong Min; Kim, Seokwoo; Rho, Junsuk
作者单位：Pohang University of Science & Technology (POSTECH); Korea Research Institute of Standards & Science (KRISS); University of Science & Technology (UST); Pohang University of Science & Technology (POSTECH); Pohang University of Science & Technology (POSTECH)
摘要：Metasurfaces have garnered significant attention for unnatural abilities to modulate waves across various physics domains, including elastics. However, existing elastic metasurfaces are limited to narrowband operations due to chromatic aberrations; moreover, these exhibit highly discrete phase profiles due to the empty spaces required for each meta- atom to function as an individual waveguide. Herein, to address these, we propose a synthesized dispersion engineering that compensates for higher...
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作者：Loftus, Kaitlyn; Luo, Yangcheng; Fan, Bowen; Kite, Edwin S.
作者单位：Columbia University; Institut Polytechnique de Paris; Ecole Polytechnique; Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; University of Chicago
摘要：Observations of the hot rocky exoplanet 55 Cancri e report significant but unexplained variability in brightness across visible and infrared bands, e.g., on subweekly timescales, its mid-infrared brightness temperature fluctuates by approximately 1,400 K (with hundreds of Kelvin uncertainty). We propose a magma temperature-cloud feedback as a potential explanation that relies on the planet's atmosphere and surface. In this feedback, under cloud-free conditions, stellar radiation heats surface ...
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作者：Feinman, Gary M.; Quequezana, Gabriela Cervantes; Green, Adam; Lawrence, Dan; Munson, Jessica; Ortman, Scott; Petrie, Cameron; Thompson, Amy; Nicholas, Linda M.
作者单位：Field Museum of Natural History (Chicago); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of York - UK; University of York - UK; Durham University; University of Colorado System; University of Colorado Boulder; University of Cambridge; University of Texas System; University of Texas Austin
摘要：Long-entrenched grand narratives have tied inequality in large human aggregations to generally linear trends, a direct outcome of domestication, then fostered by population growth and/or stepped scalar transitions in the hierarchical complexity of human institutions. This general pattern has been argued to short-circuit or reverse only in the context of cataclysmic disasters or societal breakdowns. Yet, for the most part, these universal deterministic frameworks have been constructed from hist...
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作者：Hoes, Emma; Gilardi, Fabrizio
作者单位：University of Zurich
摘要：There is broad consensus that AI presents risks, but considerable disagreement about the nature of those risks. These differing viewpoints can be understood as distinct narratives, each offering a specific interpretation of AI's potential dangers. One narrative focuses on doomsday predictions of AI posing long-term existential risks for humanity. Another narrative prioritizes immediate concerns that AI brings to society today, such as the reproduction of biases embedded into AI systems. A sign...
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作者：Ma, Ya; Zhang, Zhuyi; Cao, Xiaolian; Guo, Dianlei; Huang, Shuting; Xie, Lijing; Wu, Mingjuan; Li, Junru; Li, Chenxin; Chu, Yu; Jiang, Shuxin; Hao, Yu; Wang, Can; Zhong, Xiali; Ju, Rong; Zhang, Feng; Liu, Chunqiao; Wei, Yanhong
作者单位：Sun Yat Sen University; Sun Yat Sen University
摘要：Ischemic retinal diseases are major causes of blindness worldwide and are characterized by pathological angiogenesis. Epigenetic alterations in response to metabolic shifts in and its subsequent histone lactylation in ECs contribute to vascular disorders. However, the regulatory mechanism of establishing and sustaining lactylation modification remains elusive. Here, we showed that lactate accumulation induced histone lactylations on H3K9 and H3K18 in neovascular ECs in the proliferative stage ...
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作者：Bai, Haoliang; Lu, Tonghui; Liu, Wenzhuo; Li, Xianglin; Lv, Wenhao; Lv, Song
作者单位：Wuhan University of Technology; Wuhan University of Technology
摘要：Photovoltaic technology has emerged as a key candidate for powering underwater devices. However, traditional solar cells face limitations in real marine environments. Flexible solar cells offer new possibilities for underwater energy harvesting. This study identifies the optimal bandgap and depth for flexible underwater solar cells through detailed balance calculations and experiments. We also established an optical model for underwater flexible solar cells, determining the ideal curvature thr...
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作者：Fuller, Stephen T.; Zheng, J. -X. Kent
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：The solid-electrolyte interphase (SEI) formed on a battery electrode has been a central area of research for decades. This structurally complex layer profoundly impacts the electrochemical deposition morphology and stability of metal anodes. Departing from conventional approaches, we investigate metal dissolution-the reverse reaction of deposition-in battery environments using a state-of-the-art electroanalytical system combining a rotating-disk electrode and operando visualization. Our key fi...
