Proceedings of the National Academy of Sciences of the United States of America

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• g- factor symmetry and topology in semiconductor band states (vol 121, e2404298121, 2024) AI翻译
  作者：Sharma, Mira; DiVincenzo, David P.
• Migration shapes senescence in a long-lived bird AI翻译
  作者：Cayuela, Hugo; Roques, Sebastien; Arnaud, Antoine; Germain, Christophe; Bechet, Arnaud; Champagnon, Jocelyn
  作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier
  摘要：Each year, billions of animals migrate across the globe on diverse spatial and temporal scales. Migration behavior thus plays a fundamental role in the life cycle and Darwinian fitness of many organisms. While the influence of migration on early-life survival and reproduction is well documented, its effects on senescence (aging) in advanced age remain largely unexplored. Using a unique 44-y ring-resighting dataset from long-lived, partially migratory bird species, the Greater Flamingo (Phoenic...
• The RNA- binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development AI翻译
  作者：Li, Xiao - Jun; Morgan, Charles; Duy, Phan Q.; Evsen, Lale; Hao, Le T.; Machavoine, Roxane; Belhous, Kahina; Ernest, Sylvain; Denoyelle, Francoise; Mignot, Cyril; Brioude, Frederic; Parodi, Marine; Li, Lin; Huang, He; Ponniah, Prathamesh T. Nadar; Kolanus, Waldemar; Kahle, Kristopher T.; Marlin, Sandrine; Doetzlhofer, Angelika
  作者单位：Johns Hopkins University; Xi'an Jiaotong University; Yale University; Yale University; Yale University; Yale University; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Hopital Universitaire Saint-Louis - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Hopital Universitaire Armand-Trousseau - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Hopital Universitaire Armand-Trousseau - APHP; University of Bonn; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Johns Hopkins University; University of Sydney; Kolling Institute of Medical Research
  摘要：The RNA-binding protein TRIM71 is essential for brain development, and recent genetic studies in humans have identified TRIM71 as a risk gene for congenital hydrocephal-us (CH). Here, we show that monoallelic missense mutations in TRIM71 are associated with hearing loss (HL) and inner ear aplasia in humans. Utilizing conditional Trim71 knockout mice carrying a CH and HL-associated mutation, we demonstrate that loss of TRIM71 function during early otic development (embryonic day 9 to 10) causes...
• William S. Sly (1932-2025): A compassionate pioneer in biochemical genetics AI翻译
  作者：Sands, Mark S.; Grubb, Jeffrey H.; Vogler, Carole A.; Waheed, Abdul; Montano, Adriana M.
  作者单位：Washington University (WUSTL); Saint Louis University; Saint Louis University; Saint Louis University
  摘要：William S. Sly, MD (1932-2025) was a biochemical geneticist who received his medical degree from Saint Louis University. He received additional training at the NIH with several members of the National Academy of Science and Nobel Prize winner Marshall Nirenberg. He is best known for discovering mucopolysaccharidosis type VII and developing a Food and Drug Administration-approved treatment for it. He served in several long-term leadership roles and won many accolades, including the Passano Foun...
• Pdgf mediates a transient regeneration-activated cell state in planarian tissue regeneration AI翻译
  作者：Xu, Hao; Li, Yucong; Yang, Ling; Li, Nan; Lei, Kai
  作者单位：Zhejiang University; Westlake University; Westlake Laboratory; Westlake University; Fudan University
  摘要：The role of induced gene expression is crucial for tissue regeneration. The transient regenerative cellular state that discriminates between missing-tissue and non-missing-tissue injuries remains to be fully elucidated. In this study, we identified a homolog of Platelet-Derived Growth Factor (PDGF), named pdgf-like (pdgfl), in the planarian Schmidtea mediterranea. This gene exhibits inducible expression following missing-tissue injury in a back-and-forth manner between myosin+ muscular cells a...
• A solid-state battery capable of 180 C superfast charging and 100% energy retention at-30 °C AI翻译
  作者：Hong, Hu; Wei, Zhiquan; Wang, Yiqiao; Yang, Xinru; Guo, Xun; Nian, Qingshun; Li, Xinliang; Li, Qing; Wang, Shixun; Li, Shimei; Zhang, Dechao; Xiong, Qi; Huang, Zhaodong; Zhi, Chunyi
  作者单位：City University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation; University of Hong Kong; University of Hong Kong; Zhengzhou University; University of Macau; University of Hong Kong; University of Hong Kong
  摘要：Solid-state electrolytes (SSEs) are being extensively researched as replacements for liquid electrolytes in future batteries. Despite significant advancements, there are still challenges in using SSEs, particularly in extreme conditions. This study presents a hydrated metal-organic ionic cocrystal (HMIC) solid-state ion conductor with a solvent-assisted ion transport mechanism suitable for extreme operating conditions. Through crystal engineering strategies, the adsorption capacity of HMIC for...
• ARRDC4-mediated glycolysis enhances innate immunity to influenza A virus through fructose-1,6-bisphosphate AI翻译
  作者：Li, Yuhan; Wang, Zhen; Wang, Jie; Jiang, Zhimin; Chen, Mingyue; Ai, Hui; Ma, Chao; Tong, Qi; Liu, Litao; Velkov, Tony; Sun, Honglei; Pu, Juan; Liu, Jinhua; Dai, Chongshan; Sun, Yipeng
  作者单位：China Agricultural University; China Agricultural University; Monash University
  摘要：Glucose metabolism impacts the innate immune response against viral infection. However, the key enzymes or the natural products and mechanisms involved are not well elucidated. Here, we found that arrestin domain containing 4 (ARRDC4), a critical regulator of glucose metabolism, senses influenza A virus (IAV) infection by interacting with viral PA protein. Upregulated ARRDC4 increases the enzymatic activity of phosphofructokinase, muscle type (PFKM) via binding its His298 site to promote the p...
• Symbiosis with and mimicry of corals were facilitated by immune gene loss and body remodeling in the pygmy seahorse AI翻译
  作者：Qu, Meng; Zhang, Yingyi; Woltering, Joost; Liu, Yali; Liu, Zixuan; Wan, Shiming; Jiang, Han; Yu, Haiyan; Chen, Zelin; Wang, Xin; Zhang, Zhixin; Qin, Geng; Schneider, Ralf; Meyer, Axel; Lin, Qiang
  作者单位：Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; University of Konstanz; University of Kiel; Harvard University
  摘要：A remarkable example of symbiosis involves the pygmy seahorse (Hippocampus bargibanti). It lives obligatorily on gorgonian corals, mimicking their polyps with pink coloration and skin protuberances. Unique for seahorses, pygmy seahorses retain juvenile paedomorphic stunted snouts, resembling the coral's polyps. We analyzed the tiny seahorse's genome revealing the genomic bases of several adaptations to their mutualistic life including substantial reductions in conserved noncoding elements that...
• Danicamtiv reduces myosin's working stroke but activates the thin filament by accelerating actomyosin attachment AI翻译
  作者：Scott, Brent; Greenberg, Lina; Squarci, Caterina; Campbell, Kenneth S.; Greenberg, Michael J.
  作者单位：Washington University (WUSTL); University of Kentucky
  摘要：Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only similar to 50 to 70%. As such, there is a need to develop new treatments for patients that improve survival and quality of life. Recently, there have been efforts to develop small molecules for heart failure that directly target components of the sarcomere, including cardiac myosin. Danicamtiv is one of these molecules; however, its direct effects on myosin's sin...
• Therapeutic CD8+T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound AI翻译
  作者：Pampena, M. Betina; Samer, Sadia; Viox, Elise G.; Nguyen, Kevin; Deleage, Claire; Kuri-Cervantes, Leticia; Regan, James; Wu, Vincent H.; Docken, Steffen; Safrit, Jeffrey T.; Bar, Katharine J.; Keele, Brandon F.; Davenport, Miles P.; Paiardini, Mirko; Betts, Michael R.
  作者单位：University of Pennsylvania; University of Pennsylvania; Emory University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of New South Wales Sydney; Kirby Institute; Emory University; Sanofi-Aventis; Sanofi USA
  摘要：A primary obstacle for HIV elimination is the long-term viral reservoir in lymphoid tissues (LT) that can cause rebound viremia if therapy is stopped. Cytotoxic CD8+T cells are critical for control of HIV and Simian immunodeficiency virus (SIV) viremia; however, CD8+ T cells that migrate to LT are primarily noncytotoxic, calling into question whether these cells could reduce the viral reservoir on antiretroviral therapy (ART) or control viral replication when therapy is halted. To determine wh...