Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Cluster dynamical mean-field study of intra-unit-cell charge nematicity in hole-doped cuprates AI翻译
  作者：Kumar, Abhishek; Senechal, David; Tremblay, A. -M. S.
  作者单位：University of Sherbrooke; University of Sherbrooke
  摘要：Recent scanning-tunneling microscopy on hole-doped Bi2Sr2CaCu2O8, one of the materials of the cuprate family, finds a long-range ordered spontaneous splitting of the energy levels of oxygen orbitals inside the CuO2 unit cells [S. Wang etal., Nat. Mat. 23, 492-498 (2024)]. This spontaneous intra-unit-cell orbital ordering, also known as electronic nematicity, breaks C4 symmetry and is thought to arise from the Coulomb interaction (denoted by Vpp) between oxygen px and py electrons. In this work...
• A spectral machine learning approach to derive central aortic pressure waveforms from a brachial cuff AI翻译
  作者：Tamborini, Alessio; Aghilinejad, Arian; Gharib, Morteza
  作者单位：California Institute of Technology
  摘要：Analyzing cardiac pulse waveforms offers valuable insights into heart health and cardiovascular disease risk, although obtaining the more informative measurements from the central aorta remains challenging due to their invasive nature and limited noninvasive options. To address this, we employed a laboratory- developed cuff device for high- resolution pulse waveform acquisition and constructed a spectral machine learning model to nonlinearly map the brachial wave components to the aortic site....
• Diverse plant RNAs coat Arabidopsis leaves and are distinct from apoplastic RNAs (Vol 122, e2409090121, 2025) AI翻译
  作者：Borniego, M. Lucia; Singla-Rastogi, Meenu; Baldrich, Patricia; Sampangi-Ramaiah, Megha Hastantram; Karimi, Hana Zand; McGregor, Madison; Meyers, Blake C.; Innes, Roger W.
• Cold- blooded vertebrate utilizes behavioral fever to alleviate T cell apoptosis and optimize antimicrobial immunity (vol 121, e2408969121, 2024) AI翻译
  作者：Gao, Haiyou; Wei, Xiumei; Li, Kang; Cao, Yi; Rao, Wenzhuo; Zhang, Jiansong; Wang, Ding; Yang, Jialong
• NPF binding to Arp2 is allosterically linked to the release of ArpC5's N- terminal tail and conformational changes in Arp2/3 complex AI翻译
  作者：Saks, Andrew J.; Barrie, Kyle R.; Rebowski, Grzegorz; Dominguez, Roberto
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：Arp2/3 complex generates branched actin networks essential for numerous motile functions of the cell. It comprises seven subunits: actin- related proteins (Arps) 2 and 3 and five scaffolding subunits (ArpC1-5). The complex adopts two major conformations: inactive, with the Arps interacting end- to- end, and active, with the Arps aligned side- by- side like subunits in the actin filament. Activation involves several cofactors, including ATP, WASP- family nucleation- promoting factors (NPFs), ac...
• Temporal autocorrelation is predictive of age-An extensive MEG time- series analysis AI翻译
  作者：Stier, Christina; Balestrieri, Elio; Fehring, Jana; Focke, Niels K.; Wollbrink, Andreas; Dannlowski, Udo; Gross, Joachim
  作者单位：University of Munster; University of Munster; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Munster
  摘要：Understanding the evolving dynamics of the brain throughout life is pivotal for anticipating and evaluating individual health. While previous research has described age effects on spectral properties of neural signals, it remains unclear which ones are most indicative of age- related processes. This study addresses this gap by analyzing resting- state data obtained from magnetoencephalography (MEG) in 350 adults (18 to 88 y). We employed advanced time- series analysis at the brain region level...
• Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos AI翻译
  作者：Azbazdar, Yagmur; De Robertis, Edward M.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：We recently reported that microinjection of Xenopus nodal- related (xnr) mRNAs into beta- catenin- depleted Xenopus embryos rescued a complete dorsal axis. Xnrs mediate the signal of the Nieuwkoop center that induces the Spemann-Mangold organizer in the overlying mesoderm, a process inhibited by the Nodal antagonist Cerberus-short (CerS). However, beta- catenin also induces a second signaling center in the dorsal prospective ectoderm, designated the Blastula Chordin and Noggin Expression (BCNE...
• Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis AI翻译
  作者：Ma, Lanjing; Pang, Zhongqiu; Zhang, Haijiao; Yang, Xueling; Zheng, Shaoqin; Chen, Yi; Ding, Weijie; Han, Qing; Zhang, Xi; Cao, Liu; Fei, Teng; Wang, Qiang; Gao, Daming; He, Aina; Hu, Ke-Bang; Li, Xuexin; Sheng, Ren
  作者单位：Northeastern University - China; NewYork-Presbyterian Hospital; Columbia University; Northeastern University - China; China Medical University; South China University of Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Shanghai Jiao Tong University; Jilin University; China Medical University; China Medical University; China Medical University; Karolinska Institutet
  摘要：Clear cell renal cell carcinoma (ccRCC) is the predominant human renal cancer with surging incidence and fatality lately. Hyperactivation of hypoxia- inducible factor (HIF) and mammalian target of rapamycin (mTOR) signaling are the common signatures in ccRCC. Herein, we employed spontaneous ccRCC model to demonstrate the indispensability of an underappreciated Ser/Thr kinase, CDKL3, in the initiation and progression of ccRCC. Ablation of CDKL3 does not affect normal kidney, but abrogates Akt-m...
• Structural characterization of influenza group 1 chimeric hemagglutinins as broad vaccine immunogens AI翻译
  作者：Nguyen, Yen Thi Kim; Zhu, Xueyong; Han, Julianna; Rodriguez, Alesandra J.; Sun, Weina; Yu, Wenli; Palese, Peter; Krammer, Florian; Ward, Andrew B.; Wilson, Ian A.
  作者单位：Scripps Research Institute; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Medical University of Vienna; Scripps Research Institute
  摘要：Chimeric hemagglutinins (cHA) appear to be promising for the design and development of universal influenza vaccines. Influenza A group 1 cHAs, cH5/1, cH8/1, and cH11/1, comprising an H1 stem attached to either an H5, H8, or H11 globular head, have been used sequentially as vaccine immunogens in human clinical trials and induced high levels of broadly protective antibodies. Using X- ray crystallography and negative- stain electron microscopy, we determined structures of cH5/1, cH8/1, and cH11/1...
• Geometric modeling of knitted fabrics AI翻译
  作者：Niu, Lauren; Dion, Genevieve; Kamien, Randall D.
  作者单位：Drexel University; University of Pennsylvania
  摘要：It is undeniable that, by any metric, geometry plays a central role in our understanding of the physical world. From celestial mechanics (1) to soap bubbles (2) and from optics (3) to gravity (4), the rigor of geometric logic intoxicates our thinking. Indeed, because of their intrinsic elegance and potential application, tools have been developed to make materials that assemble into a targeted topography. Whether it be through the techniques of origami (5-7), thermal activation of local materi...