Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Synergistic anion-π interactions in peptidomimetic polyethers AI翻译
  作者：Lee, Seunghyun; Shin, Aram; Park, Jinwoo; Yun, Sowon; Kim, Minseong; Lee, Dong Woog; Kim, Byeong-Su
  作者单位：Ulsan National Institute of Science & Technology (UNIST); Yonsei University
  摘要：Anion-1t interactions are crucial in various biological processes, such as enzyme catalysis and ion transport. Despite their significance, the exploitation of anion-1t interactions in synthetic polymer systems remains underexplored. This study investigates anion-1t interactions using chemically well- defined peptidomimetics guided by the composition of mussel foot proteins. Specifically, polyether-based polymers were designed utilizing two functional epoxide monomers-catechol acetonide glycidy...
• Profile of Bik- Kwoon Tye AI翻译
  作者：Viegas, Jennifer
• Structural insights into the assembly and energy transfer of haptophyte photosystem I-light-harvesting supercomplex (vol 121, e2413678121, 2024) AI翻译
  作者：He, Fei-Yu; Zhao, Long-Sheng; Qu, Xin-Xiao; Li, Kang; Guo, Jian-Ping; Zhao, Fang; Wang, Ning; Qin, Bing-Yue; Chen, Xiu-Lan; Gao, Jun; Liu, Lu-Ning; Zhang, Yu-Zhong
• Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate AI翻译
  作者：Yin, Yan; Haller, Meade; Goldinger, Lauren; Bharadwaj, Shivani; So, Emily; Robles-Pinos, Vivian; Chen, David; Ma, Liang
  作者单位：Washington University (WUSTL)
  摘要：Classical tissue recombination experiments demonstrate that cell- fate determination along the anterior-posterior axis of the M & uuml;llerian duct occurs prior to postnatal day 7 in mice. However, little is known about how these cell types are maintained in adults. In this study, we provide genetic evidence that a balance between antagonistic retinoic acid (RA) and estrogen signaling activity is required to maintain simple columnar cell fate in adult uterine epithelium. Transdifferentiation o...
• Death-receptor activation halts clathrin-dependent endocytosis (vol 103, pg 10283, 2006) AI翻译
  作者：Austin, Cary D.; Lawrence, David A.; Peden, Andrew A.; Varfolomeev, Eugene E.; Totpal, Klara; De Maziere, Ann M.; Klumperman, Judith; Arnott, David; Pham, Victoria; Scheller, Richard H.; Ashkenazi, Avi
• Evolution of complexity through regulatory variation at a single gene AI翻译
  作者：Ferreira, Mafalda S.
  作者单位：Stockholm University
• A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in Escherichia coli AI翻译
  作者：Park, Sohee; Jeon, Wook - Jong; Lee, Yeseul; Lim, Chae Lim; Lee, Eunyeong; Oh, Han Byeol; Lee, Gyu Sung; Kwon, Oh Hyun; Ryu, Bumhan; Cho, Yong - Joon; Kim, Chung Sub; Yoon, Sung - il; Chung, Jeong Min; Cho, Hongbaek
  作者单位：Sungkyunkwan University (SKKU); Catholic University of Korea; Kangwon National University; Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); Kangwon National University; Kangwon National University; Sungkyunkwan University (SKKU)
  摘要：Bacterial cell wall assembly and remodeling require activities of peptidoglycan (PG) hydrolases as well as PG synthases. In particular, the activity of DD- endopeptidases, which cleave the 4- 3 peptide crosslinks in PG, is essential for PG expansion in gram- negative bacteria. Maintaining optimal levels of DD- endopeptidases is critical for expanding PG without compromising its integrity. In Escherichia coli, the levels of major DD- endopeptidases, MepS and MepH, along with the lytic transglyc...
• Molecular glue for phycobilisome attachment to photosystem II in Synechococcus sp. PCC 7002 AI翻译
  作者：Zheng, Zhenggao; Li, Xinrui; Wei, Peijun; Zhang, Xueang; Zhang, Tianyi; Zhang, Zhengdong; Dong, Chunxia; Zhao, Jindong
  作者单位：Peking University; Chinese Academy of Sciences; Institute of Hydrobiology, CAS
  摘要：Phycobilisomes (PBS) are the major photosynthetic light- harvesting complexes in cyanobacteria and red algae. While the structures of PBS have been determined in atomic resolutions, how PBS are attached to the reaction centers of photosystems remains less clear. Here, we report that a linker protein (LcpA) is required for the attachment of PBS to photosystem II (PSII) in the cyanobacterium Synechococcus sp. PCC 7002. We also report that the PB-loop of PBS, which is located within the alpha-APC...
• How to address solar geoengineering's transparency problem AI翻译
  作者：Talati, Shuchi; Buck, Holly Jean; Kravitz, Ben
  作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; Indiana University System; Indiana University Bloomington
• An RNase III-processed sRNA coordinates sialic acid metabolism of Salmonella enterica during gut colonization AI翻译
  作者：Chen, Ziying; Yang, Yaomei; Chen, Xiaomin; Bei, Cheng; Gao, Qian; Chao, Yanjie; Wang, Chuan
  作者单位：Fudan University; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Fudan University; Fudan University
  摘要：Sialic acids derived from colonic mucin glycans are crucial nutrients for enteric bacterial pathogens like Salmonella. The uptake and utilization of sialic acid in Salmonella depend on coordinated regulons, each activated by specific metabolites at the transcriptional level. However, the mechanisms enabling crosstalk among these regulatory circuits to synchronize gene expression remain poorly understood. Here, we identify ManS, a small noncoding RNA derived from the 3' UTR of STM1128 mRNA tran...