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作者：Ong, Seow Theng; Nam, Young - Woo; Nasburg, Joshua A.; Ramanishka, Alena; Ng, Xuan Rui; Zhuang, Zhong; Goay, Stephanie Shee Min; Nguyen, Hai M.; Singh, Latika; Singh, Vikrant; Rivera, Alicia; Eyster, M. Elaine; Xu, Yang; Alper, Seth L.; Wulff, Heike; Zhang, Miao; Chandy, K. George
作者单位：Nanyang Technological University; Chapman University System; Chapman University; University of California System; University of California Davis; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
摘要：The 1,4-dihydropyridines, drugs with well-established bioavailability and toxicity profiles, have proven efficacy in treating human hypertension, peripheral vascular disorders, and coronary artery disease. Every 1,4-dihydropyridine in clinical use blocks L-type voltage-gated calcium channels. We now report our development, using selective optimization of a side activity (SOSA), of a class of 1,4-dihydropyridines that selectively and potently inhibit the intermediate-conductance calcium-activat...
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作者：Yang, Hua; Brennan, Vincent; Gao, Zhi; Liu, Jian; Boadu, Frimpong; Cheng, Jianlin; Birchler, James A.
作者单位：University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia
摘要：Genomic imbalance refers to the more severe phenotypic consequences of changing a single chromosome compared to changing the whole genomic set. Previous genomic imbalance studies in maize have identified gene expression modulation in aneuploids of single chromosome arms. Here, the modulation of gene expression in more complex aneuploids, e.g., monosomy of one chromosome arm and trisomy of another was examined to determine the extent that combination aneuploids were additive, multiplicative, or...
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作者：Foffi, Erica; Rugolo, Francesco; Ramamurthy, Nisha; Haight, Jillian; Helke, Simone; You-Ten, Annick; Tobin, Chantal; Jafari, Soode Moghadas; Elia, Andrew J.; Berger, Thorsten; Candi, Eleonora; Melino, Gerry; Mak, Tak W.
作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; IRCCS Istituto Dermopatico dell'Immacolata (IDI); University of Rome Tor Vergata; University of Hong Kong; University of Toronto; University of Toronto
摘要：Chronic inflammatory skin disorders are characterized by keratinocyte hyperproliferation and hyperactivation as well as immune cell infiltration. We investigated whether immune cell-derived acetylcholine (ACh) is a modulator of skin inflammation in mice. Here, we identify skin epithelial B cells as a key source of ACh that damps down inflammation. We used imiquimod (IMQ) to induce inflammatory skin disease (ISD) in mice lacking ACh production specifically in B cells (ChATfl/fl;Mb1-Cre mice). I...
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作者：Bogaard, Amy; Cruz, Pablo; Fochesato, Mattia; Birch, Jennifer; Quequezana, Gabriela Cervantes; Chirikure, Shadreck; Crema, Enrico R.; Feinman, Gary M.; Green, Adam S.; Hamerow, Helena; Jin, Guiyun; Kerig, Tim; Lawrence, Dan; Mccoy, Mark D.; Munson, Jessica; Ortman, Scott G.; Petrie, Cameron A.; Roscoe, Paul
作者单位：University of Oxford; The Santa Fe Institute; Bocconi University; Bocconi University; Centre for Economic Policy Research - UK; University System of Georgia; University of Georgia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Cambridge; Field Museum of Natural History (Chicago); University of York - UK; University of York - UK; Shandong University; University of Kiel; Durham University; State University System of Florida; Florida State University; University of Colorado System; University of Colorado Boulder; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono
摘要：Here, we assess the extent to which land use relating to food acquisition (farming, herding, foraging) and associated value regimes shaped past economic inequality. We consider the hypothesis that land-use systems in which production was limited by heritable material wealth (such as land) sustained higher levels of inequality than those limited by (free) human labor. We address this hypothesis using the Global Dynamics of InequalIty (GINI) project database, estimating economic inequalities bas...
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作者：Chen, Xi; Shuai, Min; Zhong, Bingchen; Martinez, Vikina; Korblova, Eva; Glaser, Matthew A.; Maclennan, Joseph E.; Walba, David M.; Clark, Noel A.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：We report a transition from the ferroelectric nematic liquid crystal (NF) phase to a lower-temperature, apolar fluid phase having reentrant isotropic symmetry (IR), in the liquid crystal compound RM734 doped with small concentrations of the ionic liquids 1-Butyl-3-methylimidazolium hexafluorophosphate (BMIM-PF6) or 1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMIM-TFSI). Even a trace amount of ionic liquid dopant facilitates the kinetic pathway for the transition from the NF ...
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作者：Sotka, Erik E.; Carnegie, Ryan B.; Carlton, James T.; Couceiro, Lucia; Crooks, Jeffrey A.; Endo, Hikaru; Hayford, Hilary; Hori, Masakazu; Kamiya, Mitsunobu; Kanaya, Gen; Kochmann, Judith; Lee, Kun- Seop; Lees, Lauren; Miller, Hannah; Nakaoka, Masahiro; Pante, Eric; Ruesink, Jennifer L.; Schwindt, Evangelina; Strand, Asa; Taylor, Richard B.; Terada, Ryuta; Thiel, Martin; Yorisue, Takefumi; Zacherl, Danielle; Strand, Allan E.
作者单位：College of Charleston; William & Mary; Virginia Institute of Marine Science; Williams College; Universidade da Coruna; Kagoshima University; Kagoshima University; Japan Fisheries Research & Education Agency (FRA); Tokyo University of Marine Science & Technology; National Institute for Environmental Studies - Japan; Johannes Gutenberg University of Mainz; Pusan National University; University of California System; University of California Irvine; Hokkaido University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bretagne Occidentale; Ifremer; Institut de Recherche pour le Developpement (IRD); University of Washington; University of Washington Seattle; IVL Swedish Environmental Research Institute; University of Auckland; University of Auckland; Smithsonian Institution; Smithsonian Environmental Research Center; Universidad Catolica del Norte; University of Hyogo; California State University System; California State University Fullerton
摘要：The massive geographic expansion of terrestrial plant crops, livestock, and marine aqua-cultured species during the 19th and 20th centuries provided local economic benefits, stabilized food demands, and altered local ecosystems. The invasion history of these translocations remains uncertain for most species, limiting our understanding of their future adaptive potential and historical roles as vectors for coinvaded species. We provide a framework for filling this gap in invasion biology using t...
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作者：Xu, Linlin; Lyu, Xinxing; Wang, Yibo; Ni, Li; Li, Pin; Zeng, Piao; Wang, Qixia; Chang, Yunhao; Pan, Chenglong; Hu, Qingxia; Huang, Shuhong; Dang, Ningning
作者单位：Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong First Medical University & Shandong Academy of Medical Sciences; Nanjing Medical University
摘要：The Atg8-family proteins, including LC3B (microtubule-associated protein 1 light chain 3 beta), are pivotal for key steps in the autophagy process. Proper regulation of LC3B homeostasis is essential for its function. Although LC3B is modulated by various post-translational modifications (PTMs), the impact of these modifications on LC3B protein homeostasis remains unclear. Neddylation, a recently identified ubiquitin-like modification, plays diverse biological roles. Here, we identify LC3B as a...
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作者：Zhong, Ya-Ting; Huang, Li-Li; Li, Kangning; Yang, Bingke; Ye, Xueting; Zhong, Hao-Ran; Yu, Bing; Ma, Menghan; Yuan, Yuerong; Meng, Yang; Pan, Runfeng; Zhang, Haiqing; Shi, Lijun; Wang, Yunyun; Tian, Ruijun; Gao, Song; Bian, Xin
作者单位：State Key Lab Oncology South China; Sun Yat Sen University; Nankai University; Southern University of Science & Technology; Southern University of Science & Technology; Nankai University; Sun Yat Sen University; Chinese Academy of Sciences; Institute of Biophysics, CAS
摘要：Most members of the dynamin superfamily of large guanosine triphophatases (GTPases) have an ability to remodel membranes in response to guanosine triphosphate (GTP) hydrolysis. Ring Finger Protein 112 (RNF112) (ZNF179/neurolastin) is a recently identified brain-specific dynamin-like protein possessing a really interesting new gene (RING) finger domain. Despite its essential role as an E3 ligase in neuron development, the architecture of RNF112 and the exact role of its GTPase activity remain u...
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作者：Xi, Xinqi; Liu, Ling; Tuano, Natasha; Tailhades, Julien; Mouradov, Dmitri; Steen, Jason; Sieber, Oliver; Cryle, Max; Nguyen-Dumont, Tu; Segelov, Eva; Rosenbluh, Joseph
作者单位：Monash University; Monash University; Murdoch Children's Research Institute; Walter & Eliza Hall Institute; University of Melbourne; Monash University; University of Melbourne; University of Melbourne; University of Bern; University Hospital of Bern; University of Geneva; University of Bern; University Hospital of Bern; Monash University
摘要：Loss of the tumor suppressor gene (TSG) Adenomatous Polyposis Coli (APC) is a hallmark event in colorectal cancers. Since it is not possible to directly target a TSG, no treatment options are available for these patients. Here, we identify SRPJ9 and the protein secretion machinery as a unique vulnerability in cancers with heterozygous APC loss. SRPJ9 is located 15 kb from APC and is almost always codeleted in these tumors. Heterozygous APC/SRPJ9 loss leads to lower levels of SRPJ9 mRNA and pro...
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作者：Brown, Andrew W.; Chung, Simon; Koscik, Timothy; Vorland, Colby J.; Maney, Donna L.
作者单位：University of Arkansas System; University of Arkansas Medical Sciences; University of Arkansas System; University of Arkansas Medical Sciences; Indiana University System; Indiana University Bloomington; Emory University
