Proceedings of the National Academy of Sciences of the United States of America

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• Cell- type- informed genotyping of mosaic focal epilepsies reveals cell- autonomous and non- cell- autonomous disease- associated transcriptional programs AI翻译
  作者：Bizzotto, Sara; Talukdar, Maya; Stronge, Edward A.; Ramirez, Rosita B.; Yang, Yingxi; Huang, August Yue; Hu, Qiwen; Hou, Yingping; Hylton, Norma K.; Finander, Benjamin; Tillett, Ashton; Zhou, Zinan; Chhouk, Brian H.; D'Gama, Alissa M.; Yang, Edward; Green, Timothy E.; Reutens, David C.; Mullen, Saul A.; Scheffer, Ingrid E.; Hildebrand, Michael S.; Buono, Russell J.; Blumcke, Ingmar; Poduri, Annapurna H.; Khoshkhoo, Sattar; Walsh, Christopher A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; Austin Research Institute; University of Queensland; Royal Brisbane & Women's Hospital; Murdoch Children's Research Institute; Rowan University; Cooper Medical School of Rowan University; University of Erlangen Nuremberg; Cleveland Clinic Foundation; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute
  摘要：While it is widely accepted that somatic variants that activate the PI3K-mTOR pathway are a major cause of drug-resistant focal epilepsy, typically associated with focal cortical dysplasia (FCD) type 2, understanding the mechanism of epileptogenesis requires identifying genotype-associated changes at the single-cell level, which is technically challenging with existing methods. Here, we performed single-nucleus RNA-sequencing (snRNA-seq) of 18 FCD type 2 samples removed surgically for treatmen...
• Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field AI翻译
  作者：Canoyra, Sara; Marin-Moreno, Alba; Espinosa, Juan Carlos; Fernandez-Borges, Natalia; Vidal, Enric; Orge, Leonor; Benestad, Sylvie L.; Andreoletti, Olivier; Torres, Juan Maria
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Instituto Nacional Investigacion Tecnologia Agraria Alimentaria (INIA); Complutense University of Madrid; IRTA; Autonomous University of Barcelona; Autonomous University of Barcelona; IRTA; University of Tras-os-Montes & Alto Douro; University of Tras-os-Montes & Alto Douro; Norwegian Veterinary Institute; INRAE
  摘要：Prion diseases can manifest with distinct phenotypes in a single species, a phenomenon known as prion strains. Upon cross-species transmission, alterations in the disease phenotype can occur, interpreted as the emergence of a new strain. Two main and non-mutually exclusive evolutionary hypotheses have been proposed to explain this phenomenon: the conformational shift or deformed templating and the conformational selection. The conformational shift hypothesis proposes that the introduction of a...
• How to design better incentives for carbon capture and storage in the United States AI翻译
  作者：Olmstead, Sheila M.; Leibowicz, Benjamin D.; Mason, Charles F.; Waxman, Andrew R.; Grubert, Emily; Rodriguez, H. R. Huber-; Stemmler, Joseph
  作者单位：Cornell University; Cornell University; Resources for the Future; University of Texas System; University of Texas Austin; University of Wyoming; University of Texas System; University of Texas Austin; University of Notre Dame; University of Oxford
• Amino acid coating enables micromotor operation in physiological conditions AI翻译
  作者：Sun, Jia; Ding, Yusen; Ye, Yicheng; Wang, Fei; Tian, Hao; Jiang, Jiamiao; Li, Huaan; Gao, Junbin; Tan, Haixin; Peng, Fei; Tang, Jinyao; Tu, Yingfeng
  作者单位：Southern Medical University - China; Southern Medical University - China; University of Hong Kong; Guangdong Pharmaceutical University; Guangdong Pharmaceutical University; Sun Yat Sen University
  摘要：Physiological environment with high ionic strength will quench the propulsion of micro/ nanomotors (MNMs) by suppressing electric double layers, especially for those motors based on electrolyte diffusiophoresis and electrophoresis. Herein, we demonstrate an efficient, general, and simple strategy to improve the ion tolerance of light-driven titanium dioxide (TiO2) micromotors with amino acid surface modification. Compared to the bare TiO2 counterpart, L-arginine (Arg)-treated TiO2 micromotors ...
• Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation AI翻译
  作者：Bolik-Coulon, Nicolas; Rossler, Philip; Nosella, Michael L.; Kim, Tae Hun; Kay, Lewis E.
  作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Colorado System; University of Colorado Boulder; University System of Ohio; Case Western Reserve University
  摘要：Cellular DNA is wrapped about an octamer composed of four histone proteins forming intrinsically disordered tails of the histones serve as scaffolds for binding an array of proteins that regulate the fidelity of the genome and gene expression. A variety of posttranslational modifications (PTMs) on the tails have been characterized, including some that alter their overall charge; however, per- residue changes in tail electrostatic potentials for different PTMs have not been reported. Here, usin...
• Noncoding RNAs have a key role in butterfly speciation. What about other flora and fauna? AI翻译
  作者：Bolakhe, Saugat
• A conserved editing mechanism for the fidelity of bacterial cell wall biosynthesis AI翻译
  作者：Garde, Shambhavi; Selvaraj, Harikrishnan; Chandramouli, Aakash; Reddy, Gundlapally S.; Bahety, Devesh; Chodisetti, Pavan Kumar; Kamat, Siddhesh S.; Reddy, Manjula
  作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Centre for Cellular & Molecular Biology (CCMB); Indian Institute of Science Education & Research (IISER) Pune; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Scripps Research Institute
  摘要：Peptidoglycan (PG), a defining feature of the bacterial cell envelope, is crucial for cell integrity and morphology. PG is a macromolecular mesh consisting of glycan polymers crosslinked by short peptides encasing the cytoplasmic membrane. PG peptides contain two to five amino acids of both L- and D- configuration, with a conserved L- alanine residue at the first position in most bacteria. We previously identified a beta- lactam hypersensitive mutant of Escherichia coli lacking yfiH (renamed p...
• QnAs with Janet B. Pierrehumbert AI翻译
  作者：Ravindran, Sandeep; Pierrehumbert, Janet B.
• Declining winter snowpack offsets carbon storage enhancement from growing season warming in northern temperate forest ecosystems AI翻译
  作者：Rooney, Emerson Conrad-; Reinmann, Andrew B.; Templer, Pamela H.
  作者单位：Boston University; City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; Hunter College (CUNY)
  摘要：Northeastern US temperate forests are currently net carbon (C) sinks and play an important role offsetting anthropogenic C emissions, but projected climatic changes, including increased temperatures and decreased winter snowpack, may influence this C sink over the next century. Past studies show that growing season warming increases forest C storage through greater soil nutrient availability that contributes to greater rates of net photosynthesis, while reduced winter snowpack induces soil fre...
• Sustainable synthesis of polymer- grade ethylene via electrified acetylene semihydrogenation AI翻译
  作者：Yan, Zihao; Xu, Libang; Zhu, Huiyuan
  作者单位：University of Virginia; University of Virginia
  摘要：The electrocatalytic semihydrogenation of acetylene (C2H2), powered by renewable electricity, provides an energy-and cost-efficient alternative to conventional thermocatalytic methods for purifying crude ethylene (C2H4) streams. This approach provides a more sustainable route to polymer-grade C2H4 by reducing greenhouse gas emissions, yet its commercial potential remains limited by the scarcity of high-performance catalysts and the absence of comprehensive techno-economic analyses for large-sc...