Proceedings of the National Academy of Sciences of the United States of America

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• Toward elucidating the mechanism of cochlear stimulation by infrared light AI翻译
  作者：Moser, Tobias; Roos, Lennart
  作者单位：University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL
• Inferring neural population codes for Drosophila acoustic communication AI翻译
  作者：Pang, Rich; Baker, Christa A.; Murthy, Mala; Pillow, Jonathan
  作者单位：Princeton University; Princeton University; North Carolina State University
  摘要：Social communication between animals is often mediated by sequences of acoustic signals, sometimes spanning long timescales. How auditory neural circuits respond to extended input sequences to guide behavior is not understood. We address this problem using Drosophila acoustic communication, a behavior involving the male's production of and female's response to long, highly variable courtship songs. Here we ask whether female neural and behavioral responses to song are better described by a lin...
• Cancer- associated fibroblast- derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation AI翻译
  作者：Zhang, Yuyuan; Zuo, Anning; Ba, Yuhao; Liu, Shutong; Chen, Jingqi; Yang, Shuaixi; Weng, Siyuan; Chen, Yukang; Xu, Hui; Luo, Peng; Cheng, Quan; Tang, Bufu; Liu, Benyu; Zhang, Chuhan; Yang, Jingkuan; Han, Xinwei; Liu, Zaoqu
  作者单位：Zhengzhou University; Zhengzhou University; Zhengzhou University; Zhengzhou University; Southern Medical University - China; Central South University; Fudan University; Zhengzhou University; Zhengzhou University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
  摘要：Liver metastasis remains the predominant cause of mortality in patients with colorectal cancer (CRC). Nevertheless, the mechanisms underlying the initiation of colorectal cancer liver metastasis remain poorly elucidated. During the metastatic process of CRC cells from the primary site to the liver, we performed time- resolved analyses and identified a subset of tumor cells spatially located in the primary tumor and temporally distributed in the early stages of liver metastasis. These cells wer...
• 撤稿声明: Death-receptor activation halts clathrin-dependent endocytosis AI翻译
  作者：Austin, Cary D.; Lawrence, David A.; Peden, Andrew A.; Varfolomeev, Eugene E.; Totpal, Klara; De Maziere, Ann M.; Klumperman, Judith; Arnott, David; Pham, Victoria; Scheller, Richard H.; Ashkenazi, Avi
• Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways AI翻译
  作者：Li, Dongyu; Chen, Hongwen; Vale, Goncalo; Meinhardt, Nadia Elghobashi -; Hatton, Alexandra; Rong, Shunxing; McDonald, Jeffrey G.; Li, Xiaochun
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University College Dublin; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Homologous proteins share similar sequences, enabling them to work together in cells to support normal physiological functions. Phosphatidylserine synthases 1 and 2 (PSS1 and PSS2) are homologous enzymes that catalyze the synthesis of phosphatidylserine (PS) from different substrates. PSS2 shows a preference for phosphatidylethanolamine (PE) as its substrate, whereas PSS1 can utilize either PE or phosphatidylcholine. Previous their homology, our findings reveal that PSS2 exerts an opposing eff...
• Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells AI翻译
  作者：Prota, Gennaro; Berloffa, Giuliano; Awad, Wael; Vacchini, Alessandro; Chancellor, Andrew; Schaefer, Verena; Constantin, Daniel; Littler, Dene R.; Colombo, Rodrigo; Nosi, Vladimir; Mori, Lucia; Rossjohn, Jamie; De Libero, Gennaro
  作者单位：University of Basel; Monash University; Monash University; Cardiff University
  摘要：Mitochondria coordinate several metabolic pathways, producing metabolites that influence the immune response in various ways. It remains unclear whether mitochondria impact antigen presentation by the MHC-class-I-related antigen-presenting molecule, MR1, which presents small molecules to MR1-restricted T-lymphocytes. Here, we demonstrate that mitochondrial complex III and the enzyme dihydroorotate dehydrogenase are essential for the cell-surface expression of MR1 and for generating uridine-and...
• Transcriptomic and proteomic ramifications of segmental amplification in Escherichia coli AI翻译
  作者：Fritts, Ryan K.; Ebmeier, Christopher C.; Copley, Shelley D.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：Gene amplification can drive adaptation by rapidly increasing the cellular dosage of critical gene products. Segmental amplifications often encompass large genomic regions surrounding the gene(s) under selection for higher dosage. Overexpression of coamplified neighboring genes imposes a substantial metabolic burden. While compensatory mutations can decrease inappropriate overexpression of coamplified genes, it takes time for such mutations to arise. The extent to which intrinsic regulatory me...
• Why does AI hinder democratization? AI翻译
  作者：Chu, C. Y. Cyrus; Chang, Juin-Jen; Lin, Chang-Ching
  作者单位：Academia Sinica - Taiwan
  摘要：This paper examines the relationship between democrati zation and the development of AI and information and communication technology (ICT). Our empirical evidence shows that in the past 10 y, the advancement of AI/ICT has hindered the development of democracy in many countries around the world. Given that both the state rulers and civil society groups can use AI/ICT, the key that determines which side would benefit more from the advancement of these technologies hinges upon technology compleme...
• Cortical signatures linked to behavior quantitatively track arousal levels AI翻译
  作者：Gao, Sijia; Bibineyshvili, Yelena; Safavynia, Seyed A.; Calderon-Martinez, Juan; Grinspan, Zachary M.; Calderon, Diany P.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
  摘要：While current arousal level assessments in patients with disorders of consciousness discriminate altered states of consciousness, there are significant limitations in characterizing the transition from one state to another or quantifying the frequent arousal level fluctuations observed in a patient. Here, we identified a repeated, temporally discrete, dynamical pattern evident in the recovery of consciousness from anesthesia and brain injury coma models in rodents. We prospectively validated t...
• Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways AI翻译
  作者：Yang, Qing; Chen, Di; Liu, Xi; Li, Wenjie; Zheng, Huizhen; Cai, Xiaoming; Li, Ruibin
  作者单位：Soochow University - China; Soochow University - China; Soochow University - China; Technical University of Ostrava
  摘要：Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanoparticles (NPs), their potential infiltration into human breast milk remains poorly understood. This study provides a comprehensive chemical profile of NPs in human breast milk, analyzing their elemental composition, surface charge, hydrodynamic size, and crystallinity. NPs were detected in 42 out of 53 milk samples, with concentrations reaching up t...