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作者：Zhao, Jiawei; Elgeti, Matthias; O'Brien, Evan S.; Sar, Cecilia P.; El Daibani, Amal; Heng, Jie; Sun, Xiaoou; White, Elizabeth; Che, Tao; Hubbell, Wayne L.; Kobilka, Brian K.; Chen, Chunlai
作者单位：Tsinghua University; Tsinghua University; Tsinghua University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Leipzig University; Stanford University; University of Pecs; Washington University (WUSTL)
摘要：The mu-opioid receptor (mu OR) is an important target for pain management 1 and molecular understanding of drug action on mu OR will facilitate the development of better therapeutics. Here we show, using double electron-electron resonance and single-molecule fluorescence resonance energy transfer, how ligand-specific conformational changes of mu OR translate into a broad range of intrinsic efficacies at the transducer level. We identify several conformations of the cytoplasmic face of the rece...
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作者：Callaway, Ewen
摘要：Researchers deliberately infect participants with SARS-CoV-2 in 'challenge' trials - but high levels of immunity complicate efforts to test vaccines and treatments. Researchers deliberately infect participants with SARS-CoV-2 in 'challenge' trials - but high levels of immunity complicate efforts to test vaccines and treatments. An attending physician listens to the breathing of a patient who is recovering after admission to an intensive care unit (ICU) in the coronavirus (COVID-19) patient nur...
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作者：Young, Aaron W.; Geller, Shawn; Eckner, William J.; Schine, Nathan; Glancy, Scott; Knill, Emanuel; Kaufman, Adam M.
作者单位：University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University System of Maryland; University of Maryland College Park; University of Colorado System; University of Colorado Boulder
摘要：A boson sampler implements a restricted model of quantum computing. It is defined by the ability to sample from the distribution resulting from the interference of identical bosons propagating according to programmable, non-interacting dynamics1. An efficient exact classical simulation of boson sampling is not believed to exist, which has motivated ground-breaking boson sampling experiments in photonics with increasingly many photons2-12. However, it is difficult to generate and reliably evolv...
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作者：[Anonymous]
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作者：Morimoto, Juliano
作者单位：University of Aberdeen
摘要：Permanent jobs and fairer hiring practices would encourage overseas scientists to return.
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作者：Udesky, Laurie
摘要：Graduate students are relying on donated and discounted food in the struggle to make ends meet.
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作者：Riggi, Nicolo; de Sousa e Melo, Felipe
作者单位：Roche Holding; Roche Holding USA; Genentech
摘要：Cells grown on a 3D scaffold have generated a 'mini-colon' that mimics key features of the organ. Controlled expression of cancer-associated genes in the system offers a way to examine tumour formation over space and time.
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作者：Seydel, Caroline
摘要：Latest methods bring the speed, portability, and long read lengths of nanopore sequencing to proteomics.
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作者：Hossain, Amer A.; Pigli, Ying Z.; Baca, Christian F.; Heissel, Soren; Thomas, Alexis; Libis, Vincent K.; Burian, Jan; Chappie, Joshua S.; Brady, Sean F.; Rice, Phoebe A.; Marraffini, Luciano A.
作者单位：Rockefeller University; University of Chicago; Rockefeller University; Rockefeller University; Cornell University; Rockefeller University; Howard Hughes Medical Institute
摘要：Bacteria have adapted to phage predation by evolving a vast assortment of defence systems(1). Although anti-phage immunity genes can be identified using bioinformatic tools, the discovery of novel systems is restricted to the available prokaryotic sequence data(2). Here, to overcome this limitation, we infected Escherichia coli carrying a soil metagenomic DNA library(3) with the lytic coliphage T4 to isolate clones carrying protective genes. Following this approach, we identified Brig1, a DNA ...
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作者：Abraham, Mary
摘要：Some fox species leap up and pounce head first into snow to capture prey that they hear below the surface. An analysis of the forces involved reveals how the shape of the skull has evolved to minimize damage from this behaviour.
