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作者：Gomes, Joao Victor; Singh-Bhagania, Shivinder; Cenci, Matthew; Cordon, Carlos Chacon; Singh, Manjodh; Butterwick, Joel A.
作者单位：Yale University
摘要：Animals crave sugars because of their energy potential and the pleasurable sensation of tasting sweetness. Yet all sugars are not metabolically equivalent, requiring mechanisms to detect and differentiate between chemically similar sweet substances. Insects use a family of ionotropic gustatory receptors to discriminate sugars 1 , each of which is selectively activated by specific sweet molecules 2-6 . Here, to gain insight into the molecular basis of sugar selectivity, we determined structures...
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作者：Wang, Li; Qi, Jiajie; Wei, Wenya; Wu, Mengqi; Zhang, Zhibin; Li, Xiaomin; Sun, Huacong; Guo, Quanlin; Cao, Meng; Wang, Qinghe; Zhao, Chao; Sheng, Yuxuan; Liu, Zhetong; Liu, Can; Wu, Muhong; Xu, Zhi; Wang, Wenlong; Hong, Hao; Gao, Peng; Wu, Menghao; Wang, Zhu-Jun; Xu, Xiaozhi; Wang, Enge; Ding, Feng; Zheng, Xiaorui; Liu, Kaihui; Bai, Xuedong
作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Peking University; South China Normal University; Westlake University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Huazhong University of Science & Technology; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter; Renmin University of China; Peking University; Peking University; Songshan Lake Materials Laboratory; ShanghaiTech University
摘要：Within the family of two-dimensional dielectrics, rhombohedral boron nitride (rBN) is considerably promising owing to having not only the superior properties of hexagonal boron nitride1-4-including low permittivity and dissipation, strong electrical insulation, good chemical stability, high thermal conductivity and atomic flatness without dangling bonds-but also useful optical nonlinearity and interfacial ferroelectricity originating from the broken in-plane and out-of-plane centrosymmetry5-23...
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作者：Neyens, Samuel; Zietz, Otto K.; Watson, Thomas F.; Luthi, Florian; Nethwewala, Aditi; George, Hubert C.; Henry, Eric; Islam, Mohammad; Wagner, Andrew J.; Borjans, Felix; Connors, Elliot J.; Corrigan, J.; Curry, Matthew J.; Keith, Daniel; Kotlyar, Roza; Lampert, Lester F.; Madzik, Mateusz T.; Millard, Kent; Mohiyaddin, Fahd A.; Pellerano, Stefano; Pillarisetty, Ravi; Ramsey, Mick; Savytskyy, Rostyslav; Schaal, Simon; Zheng, Guoji; Ziegler, Joshua; Bishop, Nathaniel C.; Bojarski, Stephanie; Roberts, Jeanette; Clarke, James S.
作者单位：Intel Corporation; Intel USA
摘要：Building a fault-tolerant quantum computer will require vast numbers of physical qubits. For qubit technologies based on solid-state electronic devices 1-3 , integrating millions of qubits in a single processor will require device fabrication to reach a scale comparable to that of the modern complementary metal-oxide-semiconductor (CMOS) industry. Equally important, the scale of cryogenic device testing must keep pace to enable efficient device screening and to improve statistical metrics such...
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作者：Fianu, Isaac; Ochmann, Moritz; Walshe, James L.; Dybkov, Olexandr; Cruz, Joseph Neos; Urlaub, Henning; Cramer, Patrick
作者单位：University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen
摘要：The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal region of genes. Previous work has shed light on how Integrator binds to the paused elongation complex consisting of Pol II, the DRB sensitivity-inducing factor (DSIF) and the negative elongation factor (NELF) and how it cleaves the nascent RNA transcript 1 , but has not explained how Integrator removes Pol II from the DNA template. Here we present three cryo-electron microscopy structures of the complete ...
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作者：Kyriacou, Charalambos P.
作者单位：University of Leicester
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作者：Wang, Tian-Ci; Mai, Binh Khanh; Zhang, Zheng; Bo, Zhiyu; Li, Jiedong; Liu, Peng; Yang, Yang
作者单位：University of California System; University of California Santa Barbara; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California Santa Barbara
摘要：Photobiocatalysis-where light is used to expand the reactivity of an enzyme-has recently emerged as a powerful strategy to develop chemistries that are new to nature. These systems have shown potential in asymmetric radical reactions that have long eluded small-molecule catalysts1. So far, unnatural photobiocatalytic reactions are limited to overall reductive and redox-neutral processes2-9. Here we report photobiocatalytic asymmetric sp3-sp3 oxidative cross-coupling between organoboron reagent...
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作者：[Anonymous]
摘要：The common fungus Aspergillus niger removes both heavy metals and organic pollutants from its surroundings.
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作者：Lu, Chenhao; Jiang, Haibo; Cheng, Xiangran; He, Jiqing; Long, Yao; Chang, Yingfan; Gong, Xiaocheng; Zhang, Kun; Li, Jiaxin; Zhu, Zhengfeng; Wu, Jingxia; Wang, Jiajia; Zheng, Yuanyuan; Shi, Xiang; Ye, Lei; Liao, Meng; Sun, Xuemei; Wang, Bingjie; Chen, Peining; Wang, Yonggang; Peng, Huisheng
作者单位：Fudan University; Fudan University; Fudan University; Fudan University
摘要：Replacement of liquid electrolytes with polymer gel electrolytes is recognized as a general and effective way of solving safety problems and achieving high flexibility in wearable batteries(1-6). However, the poor interface between polymer gel electrolyte and electrode, caused by insufficient wetting, produces much poorer electrochemical properties, especially during the deformation of the battery(7-9). Here we report a strategy for designing channel structures in electrodes to incorporate pol...
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作者：Xu, Weichen; Zhang, Ruiyong; Duan, Jizhou; Greenfield, Donald Terry
作者单位：Chinese Academy of Sciences
摘要：Letter to the Editor
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作者：[Anonymous]
摘要：Findings underscore that genetic factors contribute to development of the condition after a traumatic incident.
