Nature

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• 85 million cells - and counting - at your fingertips AI翻译
  作者：Perkel, Jeffrey M.
  摘要：Chan Zuckerberg CELL by GENE Discover aims to be a one-stop shop for single-cell RNA sequencing data storage, access and analysis.
• Controlling the helicity of light by electrical magnetization switching (vol 627, pg 783, 2024) AI翻译
  作者：Dainone, Pambiang Abel; Prestes, Nicholas Figueiredo; Renucci, Pierre; Bouche, Alexandre; Morassi, Martina; Devaux, Xavier; Lindemann, Markus; George, Jean-Marie; Jaffres, Henri; Lemaitre, Aristide; Xu, Bo; Stoffel, Mathieu; Chen, Tongxin; Lombez, Laurent; Lagarde, Delphine; Cong, Guangwei; Ma, Tianyi; Pigeat, Philippe; Vergnat, Michel; Rinnert, Herve; Marie, Xavier; Han, Xiufeng; Mangin, Stephane; Rojas-Sanchez, Juan-Carlos; Wang, Jian-Ping; Beard, Matthew C.; Gerhardt, Nils C.; Zutic, Igor; Lu, Yuan
• Do insects have an inner life? Animal consciousness needs a rethink AI翻译
  作者：Lenharo, Mariana
  摘要：A declaration signed by dozens of scientists says there is 'a realistic possibility' for elements of consciousness in reptiles, insects and molluscs.
• Multimodal cell atlas of the ageing human skeletal muscle AI翻译
  作者：Lai, Yiwei; Ramirez-Pardo, Ignacio; Isern, Joan; An, Juan; Perdiguero, Eusebio; Serrano, Antonio L.; Li, Jinxiu; Garcia-Dominguez, Esther; Segales, Jessica; Guo, Pengcheng; Lukesova, Vera; Andres, Eva; Zuo, Jing; Yuan, Yue; Liu, Chuanyu; Vina, Jose; Domenech-Fernandez, Julio; Gomez-Cabrera, Mari Carmen; Song, Yancheng; Liu, Longqi; Xu, Xun; Munoz-Canoves, Pura; Esteban, Miguel A.
  作者单位：Beijing Genomics Institute (BGI); Pompeu Fabra University; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Valencia; CIBER - Centro de Investigacion Biomedica en Red; CIBERFES; Jilin University; University of Navarra; Guangdong Pharmaceutical University; ICREA; Guangzhou Medical University
  摘要：Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people(1). Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing(2). Yet, progress has been slow, partly due to the difficulties of characterizing skeletal muscle niche heterogeneity (whereby myofibres are the most abundant) and obtaining well-haracterized human samples(3,4). Here we ...
• Climate-targets group should rescind its endorsement of carbon offsets AI翻译
  作者：Anderegg, William R. L.; Blanchard, Libby
  作者单位：Utah System of Higher Education; University of Utah
  摘要：Letter to the Editor
• Neural crest origin of sympathetic neurons at the dawn of vertebrates AI翻译
  作者：Edens, Brittany M.; Stundl, Jan; Urrutia, Hugo A.; Bronner, Marianne E.
  作者单位：California Institute of Technology; University of South Bohemia Ceske Budejovice
  摘要：The neural crest is an embryonic stem cell population unique to vertebrates(1) whose expansion and diversification are thought to have promoted vertebrate evolution by enabling emergence of new cell types and structures such as jaws and peripheral ganglia(2). Although jawless vertebrates have sensory ganglia, convention has it that trunk sympathetic chain ganglia arose only in jawed vertebrates(3-8). Here, by contrast, we report the presence of trunk sympathetic neurons in the sea lamprey, Pet...
• Long-term continuous ammonia electrosynthesis AI翻译
  作者：Li, Shaofeng; Zhou, Yuanyuan; Fu, Xianbiao; Pedersen, Jakob B.; Saccoccio, Mattia; Andersen, Suzanne Z.; Enemark-Rasmussen, Kasper; Kempen, Paul J.; Damsgaard, Christian Danvad; Xu, Aoni; Sazinas, Rokas; Mygind, Jon Bjarke Valbaek; Deissler, Niklas H.; Kibsgaard, Jakob; Vesborg, Peter C. K.; Norskov, Jens K.; Chorkendorff, Ib
  作者单位：Technical University of Denmark; Technical University of Denmark; Technical University of Denmark
  摘要：Ammonia is crucial as a fertilizer and in the chemical industry and is considered to be a carbon-free fuel1. Ammonia electrosynthesis from nitrogen under ambient conditions offers an attractive alternative to the Haber-Bosch process2,3, and lithium-mediated nitrogen reduction represents a promising approach to continuous-flow ammonia electrosynthesis, coupling nitrogen reduction with hydrogen oxidation4. However, tetrahydrofuran, which is commonly used as a solvent, impedes long-term ammonia p...
• A recently quenched galaxy 700 million years after the Big Bang AI翻译
  作者：Looser, Tobias J.; D'Eugenio, Francesco; Maiolino, Roberto; Witstok, Joris; Sandles, Lester; Curtis-Lake, Emma; Chevallard, Jacopo; Tacchella, Sandro; Johnson, Benjamin D.; Baker, William M.; Suess, Katherine A.; Carniani, Stefano; Ferruit, Pierre; Arribas, Santiago; Bonaventura, Nina; Bunker, Andrew J.; Cameron, Alex J.; Charlot, Stephane; Curti, Mirko; de Graaff, Anna; Maseda, Michael V.; Rawle, Tim; Rix, Hans-Walter; Del Pino, Bruno Rodriguez; Smit, Renske; Ubler, Hannah; Willott, Chris; Alberts, Stacey; Egami, Eiichi; Eisenstein, Daniel J.; Endsley, Ryan; Hausen, Ryan; Rieke, Marcia; Robertson, Brant; Shivaei, Irene; Williams, Christina C.; Boyett, Kristan; Chen, Zuyi; Ji, Zhiyuan; Jones, Gareth C.; Kumari, Nimisha; Nelson, Erica; Perna, Michele; Saxena, Aayush; Scholtz, Jan
  作者单位：University of Cambridge; University of Cambridge; University of London; University College London; University of Hertfordshire; University of Oxford; Harvard University; Smithsonian Institution; University of California System; University of California Santa Cruz; Stanford University; Stanford University; Scuola Normale Superiore di Pisa; European Space Agency; European Space Astronomy Center; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Astrobiologia (INTA); University of Copenhagen; Niels Bohr Institute; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); European Southern Observatory; Max Planck Society; University of Wisconsin System; University of Wisconsin Madison; Space Telescope Science Institute; Liverpool John Moores University; National Research Council Canada; University of Arizona; University of Texas System; University of Texas Austin; Johns Hopkins University; University of Melbourne; Space Telescope Science Institute; University of Colorado System; University of Colorado Boulder
  摘要：Local and low-redshift (z < 3) galaxies are known to broadly follow a bimodal distribution: actively star-forming galaxies with relatively stable star-formation rates and passive systems. These two populations are connected by galaxies in relatively slow transition. By contrast, theory predicts that star formation was stochastic at early cosmic times and in low-mass systems(1,2,3,4). These galaxies transitioned rapidly between starburst episodes and phases of suppressed star formation, potenti...
• The variation and evolution of complete human centromeres AI翻译
  作者：Logsdon, Glennis A.; Rozanski, Allison N.; Ryabov, Fedor; Potapova, Tamara; Shepelev, Valery A.; Catacchio, Claudia R.; Porubsky, David; Mao, Yafei; Yoo, Dongahn; Rautiainen, Mikko; Koren, Sergey; Nurk, Sergey; Lucas, Julian K.; Hoekzema, Kendra; Munson, Katherine M.; Gerton, Jennifer L.; Phillippy, Adam M.; Ventura, Mario; Alexandrov, Ivan A.; Eichler, Evan E.
  作者单位：University of Washington; University of Washington Seattle; HSE University (National Research University Higher School of Economics); Stowers Institute for Medical Research; Universita degli Studi di Bari Aldo Moro; Shanghai Jiao Tong University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz; Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Pennsylvania; University of Helsinki; Oxford Nanopore Technologies
  摘要：Human centromeres have been traditionally very difficult to sequence and assemble owing to their repetitive nature and large size(1). As a result, patterns of human centromeric variation and models for their evolution and function remain incomplete, despite centromeres being among the most rapidly mutating regions(2,3). Here, using long-read sequencing, we completely sequenced and assembled all centromeres from a second human genome and compared it to the finished reference genome(4,5). We fin...
• PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells AI翻译
  作者：Lacher, Sebastian B.; Doerr, Janina; de Almeida, Gustavo P.; Hoenninger, Julian; Bayerl, Felix; Hirschberger, Anna; Pedde, Anna-Marie; Meiser, Philippa; Ramsauer, Lukas; Rudolph, Thomas J.; Spranger, Nadine; Morotti, Matteo; Grimm, Alizee J.; Jarosch, Sebastian; Oner, Arman; Gregor, Lisa; Lesch, Stefanie; Michaelides, Stefanos; Fertig, Luisa; Briukhovetska, Daria; Majed, Lina; Stock, Sophia; Busch, Dirk H.; Buchholz, Veit R.; Knolle, Percy A.; Zehn, Dietmar; Dangaj Laniti, Denarda; Kobold, Sebastian; Boettcher, Jan P.
  作者单位：Technical University of Munich; University of Munich; University of Munich; Technical University of Munich; Technical University of Munich; University of Lausanne; Ludwig Institute for Cancer Research; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); University of Munich; Boehringer Ingelheim
  摘要：Cancer-specific TCF1(+) stem-like CD8(+) T cells can drive protective anticancer immunity through expansion and effector cell differentiation(1,2,3,4); however, this response is dysfunctional in tumours. Current cancer immunotherapies(2,5,6,7,8,9) can promote anticancer responses through TCF1(+) stem-like CD8(+) T cells in some but not all patients. This variation points towards currently ill-defined mechanisms that limit TCF1(+)CD8(+) T cell-mediated anticancer immunity. Here we demonstrate t...