'Mini-colons' shed light on cancer progression

• 成果类型: Editorial Material
• 署名作者: Riggi, Nicolo; de Sousa e Melo, Felipe
• 署名单位: Roche Holding; Roche Holding USA; Genentech
• 刊物名称: Nature
• ISSN/ISSBN: 0028-6394
• DOI: 10.1038/d41586-024-01018-3
• 发表日期: 2024-05-09
• 页码: 292-293
• 关键词: stem-cells

摘要

Cells grown on a 3D scaffold have generated a 'mini-colon' that mimics key features of the organ. Controlled expression of cancer-associated genes in the system offers a way to examine tumour formation over space and time.