Nature

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• ONLINE TOOL IDENTIFIES PAPERS DISCUSSED ON PUBPEER AI翻译
  作者：Chawla, Dalmeet Singh
  摘要：Browser plug-in alerts users when studies - or their references - have been posted on a site known for raising integrity concerns. Browser plug-in alerts users when studies - or their references - have been posted on a site known for raising integrity concerns. A magnifying glass illuminated by the screen of a partial open laptop in the dark.
• Seek out the last 'monumental' corals AI翻译
  作者：Montano, Simone; Siena, Federica; Strona, Giovanni
  作者单位：University of Milano-Bicocca; European Commission Joint Research Centre; EC JRC ISPRA Site
• Coupled neural activity controls working memory in humans AI翻译
  作者：Williams, Ziv
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School
  摘要：How does the human brain temporarily store information without losing track of it? Neuroscientists have discovered that neurons in the frontal and temporal lobes work together to hold information in working memory.
• NOT JUST TRUFFLES: DOGS CAN SNIFF OUT RARE WILD FUNGUS AI翻译
  作者：[Anonymous]
• A high-density and high-confinement tokamak plasma regime for fusion energy AI翻译
  作者：Ding, S.; Garofalo, A. M.; Wang, H. Q.; Weisberg, D. B.; Li, Z. Y.; Jian, X.; Eldon, D.; Victor, B. S.; Marinoni, A.; Hu, Q. M.; Carvalho, I. S.; Odstrcil, T.; Wang, L.; Hyatt, A. W.; Osborne, T. H.; Gong, X. Z.; Qian, J. P.; Huang, J.; McClenaghan, J.; Holcomb, C. T.; Hanson, J. M.
  作者单位：General Atomics & Affiliated Companies; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Massachusetts Institute of Technology (MIT); Princeton University; United States Department of Energy (DOE); Princeton Plasma Physics Laboratory; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Columbia University
  摘要：The tokamak approach, utilizing a toroidal magnetic field configuration to confine a hot plasma, is one of the most promising designs for developing reactors that can exploit nuclear fusion to generate electrical energy(1,2). To reach the goal of an economical reactor, most tokamak reactor designs(3-10) simultaneously require reaching a plasma line-averaged density above an empirical limit-the so-called Greenwald density(11)-and attaining an energy confinement quality better than the standard ...
• Beware of graphene's huge and hidden environmental costs AI翻译
  作者：Guo, Shijie; Cai, Zihan; Yang, Yanchao; Ding, Qingyuan
  作者单位：Hong Kong Polytechnic University; Nanyang Technological University; North China University of Science & Technology; University of Murcia
  摘要：Letter to the Editor
• The Light Eaters: How the Unseen World of Plant Intelligence Offers a New Understanding of Life on Earth AI翻译
  作者：Montgomery, Beronda L.
• Ghost roads and the destruction of Asia-Pacific tropical forests AI翻译
  作者：Engert, Jayden E.; Campbell, Mason J.; Cinner, Joshua E.; Ishida, Yoko; Sloan, Sean; Supriatna, Jatna; Alamgir, Mohammed; Cislowski, Jaime; Laurance, William F.
  作者单位：James Cook University; James Cook University; James Cook University; University of Indonesia; University of Indonesia; University of Sydney; Vancouver Island University
  摘要：Roads are expanding at the fastest pace in human history. This is the case especially in biodiversity-rich tropical nations, where roads can result in forest loss and fragmentation, wildfires, illicit land invasions and negative societal effects 1-5 . Many roads are being constructed illegally or informally and do not appear on any existing road map 6-10 ; the toll of such 'ghost roads' on ecosystems is poorly understood. Here we use around 7,000 h of effort by trained volunteers to map ghost ...
• How rich is too rich? AI翻译
  作者：Chancel, Lucas
  作者单位：Harvard University; Institut d'Etudes Politiques Paris (Sciences Po); Paris School of Economics
  摘要：Where should society draw the line on extreme wealth? A fresh account sets out the logic and suggests how to redress inequality.
• Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers AI翻译
  作者：Ferretti, Stephane; Hamon, Jacques; de Kanter, Ruben; Scheufler, Clemens; Andraos-Rey, Rita; Barbe, Stephanie; Bechter, Elisabeth; Blank, Jutta; Bordas, Vincent; Dammassa, Ernesta; Decker, Andrea; Di Nanni, Noemi; Dourdoigne, Marion; Gavioli, Elena; Hattenberger, Marc; Heuser, Alisa; Hemmerlin, Christelle; Hinrichs, Juergen; Kerr, Grainne; Laborde, Laurent; Jaco, Isabel; Nunez, Eloisa Jimenez; Martus, Hans-Joerg; Quadt, Cornelia; Reschke, Markus; Romanet, Vincent; Schaeffer, Fanny; Schoepfer, Joseph; Schrapp, Maxime; Strang, Ross; Voshol, Hans; Wartmann, Markus; Welly, Sarah; Zecri, Frederic; Hofmann, Francesco; Moebitz, Henrik; Cortes-Cros, Marta
  作者单位：Novartis; Novartis; Novartis; Novartis USA
  摘要：The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal target in cancer cells with microsatellite instability (MSI) by several genetic screens(1-6). Despite advances in treatment with immune checkpoint inhibitors(7-10), there is an unmet need in the treatment of MSI cancers(11-14). Here we report the structural, biochemical, cellular and pharmacological characterization of the clinical-stage WRN helicase inhibitor HRO761, which was identified through an innovative hit-findi...