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作者：Willyard, Cassandra
摘要：Regulators have identified around 30 cases of cancer linked to this blockbuster treatment. But is CAR T to blame? The hunt is on for answers.
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作者：Chan, Wei-Ping; Lenoir, Jonathan; Mai, Guan-Shuo; Kuo, Hung-Chi; Chen, I-Ching; Shen, Sheng-Feng
作者单位：Academia Sinica - Taiwan; Harvard University; Taipei Medical University; Harvard University; Centre National de la Recherche Scientifique (CNRS); Universite de Picardie Jules Verne (UPJV); National Taiwan University; National Cheng Kung University; Stanford University
摘要：Mountain ranges contain high concentrations of endemic species and are indispensable refugia for lowland species that are facing anthropogenic climate change 1,2 . Forecasting biodiversity redistribution hinges on assessing whether species can track shifting isotherms as the climate warms 3,4 . However, a global analysis of the velocities of isotherm shifts along elevation gradients is hindered by the scarcity of weather stations in mountainous regions 5 . Here we address this issue by mapping...
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作者：Bizoza, Alfred R.
作者单位：University of Rwanda
摘要：Simple measures to strengthen the interface between science, policy and society in African nations could help the continent leapfrog others in sustainable innovation and development.
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作者：Kozlov, Max
摘要：A cluster of mpox cases in the Democratic Republic of the Congo sparks worries of a wider outbreak.
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作者：Lupianez, Dario G.
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD)
摘要：A parachute-like skin membrane, the patagium, evolved independently in several marsupial species. Genomic analysis suggests that this trait came about through different changes to the regulation of the same gene.
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作者：Doan, Alexander; Mueller, Katherine; Chen, Andy; Rouin, Geoffrey; Chen, Yingshi; Daniel, Bence; Lattin, John; Markovska, Martina; Mozarsky, Brett; Arias-Umana, Jose; Hapke, Robert; Jung, In-Young; Wang, Alice; Xu, Peng; Klysz, Dorota; Zuern, Gabrielle; Bashti, Malek; Quinn, Patrick; Miao, Zhuang; Sandor, Katalin; Zhang, Wenxi; Chen, Gregory; Ryu, Faith; Logun, Meghan; Hall, Junior; Tan, Kai; Grupp, Stephan; Mcclory, Susan; Lareau, Caleb; Fraietta, Joseph; Sotillo, Elena; Satpathy, Ansuman; Mackall, Crystal; Weber, Evan
作者单位：Stanford University; Stanford Cancer Institute; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Stanford University; Stanford University; Stanford University; Stanford University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Stanford University; Stanford University; Roche Holding; Genentech; Roche Holding USA
摘要：A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence of these cells in vivo 1 . The expression of memory-associated genes in CAR T cells is linked to their long-term persistence in patients and clinical efficacy 2-6 , suggesting that memory programs may underpin durable CAR T cell function. Here we show that the transcription factor FOXO1 is responsible for promoting memory and restraining exhaustion in human CAR T cells. Pharmacological inhibition or ...
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作者：Li, Fei; Xing, Xudong; Jin, Qiqi; Wang, Xiang-Ming; Dai, Pengfei; Han, Ming; Shi, Huili; Zhang, Ze; Shao, Xianlong; Peng, Yunyi; Zhu, Yiqin; Xu, Jiayi; Li, Dan; Chen, Yu; Wu, Wei; Wang, Qiao; Yu, Chen; Chen, Luonan; Bai, Fan; Gao, Dong
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Normal University; Memorial Sloan Kettering Cancer Center; Fudan University; Shenzhen Bay Laboratory
摘要：Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens1-7. However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased im...
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作者：[Anonymous]
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作者：Adam, David
摘要：Researchers from several disciplines hope to predict - and prevent - scenarios that pose risks to humanity.
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作者：Cahill, Michelle K.; Collard, Max; Tse, Vincent; Reitman, Michael E.; Etchenique, Roberto; Kirst, Christoph; Poskanzer, Kira E.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; University of California System; University of California San Francisco; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Astrocytes, the most abundant non-neuronal cell type in the mammalian brain, are crucial circuit components that respond to and modulate neuronal activity through calcium (Ca2+) signalling 1-7 . Astrocyte Ca2+ activity is highly heterogeneous and occurs across multiple spatiotemporal scales-from fast, subcellular activity 3,4 to slow, synchronized activity across connected astrocyte networks 8-10 -to influence many processes 5,7,11 . However, the inputs that drive astrocyte network dynamics re...
