Nature

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• Neural pathways for reward and relief promote fentanyl addiction AI翻译
  作者：Heilig, Markus; Petrella, Michele
  作者单位：Linkoping University
  摘要：Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal.
• Who will make AlphaFold3 open source? AI翻译
  作者：Callaway, Ewen
  摘要：Researchers are aiming to create fully accessible versions of the latest iteration of DeepMind's blockbuster protein-structure model.
• Element from the periodic table's far reaches coaxed into elusive compound AI翻译
  作者：Peplow, Mark
  摘要：Chemists achieve synthetic feat with radioactive promethium for the first time.
• Membraneless channels sieve cations in ammonia-oxidizing marine archaea AI翻译
  作者：von Kuegelgen, Andriko; Cassidy, C. Keith; van Dorst, Sofie; Pagani, Lennart L.; Batters, Christopher; Ford, Zephyr; Loewe, Jan; Alva, Vikram; Stansfeld, Phillip J.; Bharat, Tanmay A. M.
  作者单位：MRC Laboratory Molecular Biology; University of Oxford; University of Missouri System; University of Missouri Columbia; MRC Laboratory Molecular Biology; University of Warwick
  摘要：Nitrosopumilus maritimus is an ammonia-oxidizing archaeon that is crucial to the global nitrogen cycle(1,2). A critical step for nitrogen oxidation is the entrapment of ammonium ions from a dilute marine environment at the cell surface and their subsequent channelling to the cell membrane of N. maritimus. Here we elucidate the structure of the molecular machinery responsible for this process, comprising the surface layer (S-layer), using electron cryotomography and subtomogram averaging from c...
• Designer porous solids open up vast sandbox for materials research AI翻译
  作者：Bucar, Dejan-Kresimir
  作者单位：University of London; University College London
  摘要：A simple design approach and predictive computational methods have spawned a pathway for making materials that could trap specific molecules - an ability needed for applications such as carbon capture.
• Misinformation poses a bigger threat to democracy than you might think AI翻译
  作者：Ecker, Ullrich; Roozenbeek, Jon; van der Linden, Sander; Tay, Li Qian; Cook, John; Oreskes, Naomi; Lewandowsky, Stephan
  作者单位：University of Western Australia; University of London; King's College London; University of Cambridge; Australian National University; University of Melbourne; University of Bristol
  摘要：In today's polarized political climate, researchers who combat mistruths have come under attack and been labelled as unelected arbiters of truth. But the fight against misinformation is valid, warranted and urgently required.
• What steps to take when funding starts to run out AI翻译
  作者：Savage, Neil
  摘要：Although researchers often face uncertainty when grants expire with no replacement in sight, there are creative ways to ease the dry spell.
• How to keep the lights on: the mission to make more photostable fluorophores AI翻译
  作者：Remmel, Ariana
  摘要：Fluorescent labels that have greater resistance to bleaching could help researchers to get more from biological imaging.
• Cells cope with altered chromosome numbers by enhancing protein breakdown AI翻译
  作者：Storchova, Zuzana
  摘要：When chromosomes are lost or gained, massive changes in gene expression disrupt the delicate balance of proteins in a cell. Yeasts with incorrect chromosome numbers counteract this by degrading excess proteins.
• Porous isoreticular non-metal organic frameworks AI翻译
  作者：O'Shaughnessy, Megan; Glover, Joseph; Hafizi, Roohollah; Barhi, Mounib; Clowes, Rob; Chong, Samantha Y.; Argent, Stephen P.; Day, Graeme M.; Cooper, Andrew I.
  作者单位：University of Liverpool; University of Liverpool; University of Southampton; University of Liverpool; University of Liverpool; University of Nottingham
  摘要：Metal-organic frameworks (MOFs) are useful synthetic materials that are built by the programmed assembly of metal nodes and organic linkers(1). The success of MOFs results from the isoreticular principle(2), which allows families of structurally analogous frameworks to be built in a predictable way. This relies on directional coordinate covalent bonding to define the framework geometry. However, isoreticular strategies do not translate to other common crystalline solids, such as organic salts(...