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作者：Walzer, Katelyn A.; Tandel, Jayesh; Byerly, Jessica H.; Daniels, Abigail M.; Gullicksrud, Jodi A.; Whelan, Eoin C.; Carro, Stephen D.; Krespan, Elise; Beiting, Daniel P.; Striepen, Boris
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children, and a cause and consequence of chronic malnutrition(1,2). There are no vaccines and only limited treatment options(3). The parasite infects enterocytes, in which it engages in asexual and sexual replication(4), both of which are essential to continued infection and transmission. However, their molecular mechanisms remain largely unclear(5). Here we use single-cell RNA sequencing to reveal the gene expressi...
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作者：Malabarba, Luiz Roberto; Becker, Fernando Gertum; Ramos Pereira, Maria Joao; Borges-Martins, Marcio
作者单位：Universidade Federal do Rio Grande do Sul
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作者：Bublitz, Christoph
作者单位：University of Hamburg
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作者：Budak, Ceren; Nyhan, Brendan; Rothschild, David M.; Thorson, Emily; Watts, Duncan J.
作者单位：University of Michigan System; University of Michigan; Dartmouth College; Microsoft; Syracuse University; University of Pennsylvania
摘要：The controversy over online misinformation and social media has opened a gap between public discourse and scientific research. Public intellectuals and journalists frequently make sweeping claims about the effects of exposure to false content online that are inconsistent with much of the current empirical evidence. Here we identify three common misperceptions: that average exposure to problematic content is high, that algorithms are largely responsible for this exposure and that social media i...
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作者：[Anonymous]
摘要：Automated approaches to translation could provide a lifeline to under-resourced languages, but only if companies engage with the people who speak them.
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作者：Ahmad, Wajeeha; Sen, Ananya; Eesley, Charles; Brynjolfsson, Erik
作者单位：Stanford University; Carnegie Mellon University; Stanford University
摘要：The financial motivation to earn advertising revenue has been widely conjectured to be pivotal for the production of online misinformation(1-4). Research aimed at mitigating misinformation has so far focused on interventions at the user level(5-8), with little emphasis on how the supply of misinformation can itself be countered. Here we show how online misinformation is largely financed by advertising, examine how financing misinformation affects the companies involved, and outline interventio...
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作者：Ulvund, Kristine; Nuwer, Rachel
作者单位：Norwegian Institute Nature Research
摘要：Over the past 25 years, Kristine Ulvund has helped to increase the species' population size from 50 or so individuals to more than 500.
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作者：Kulkarni, Sumeet
摘要：Two particular broods of the insects are popping up together for the first time in two centuries, and there's a lot we don't know about them.
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作者：Gribben, Christopher; Galanakis, Vasileios; Calderwood, Alexander; Williams, Eleanor C.; Chazarra-Gil, Ruben; Larraz, Miguel; Frau, Carla; Puengel, Tobias; Guillot, Adrien; Rouhani, Foad J.; Mahbubani, Krishnaa; Godfrey, Edmund; Davies, Susan E.; Athanasiadis, Emmanouil; Saeb-Parsy, Kourosh; Tacke, Frank; Allison, Michael; Mohorianu, Irina; Vallier, Ludovic
作者单位：University of Cambridge; University of Cambridge; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Francis Crick Institute; University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; Academy of Athens; University of West Attica; Max Planck Society
摘要：For many adult human organs, tissue regeneration during chronic disease remains a controversial subject. Regenerative processes are easily observed in animal models, and their underlying mechanisms are becoming well characterized(1-4), but technical challenges and ethical aspects are limiting the validation of these results in humans. We decided to address this difficulty with respect to the liver. This organ displays the remarkable ability to regenerate after acute injury, although liver rege...
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作者：Matchett, K. P.; Wilson-Kanamori, J. R.; Portman, J. R.; Kapourani, C. A.; Fercoq, F.; May, S.; Zajdel, E.; Beltran, M.; Sutherland, E. F.; Mackey, J. B. G.; Brice, M.; Wilson, G. C.; Wallace, S. J.; Kitto, L.; Younger, N. T.; Dobie, R.; Mole, D. J.; Oniscu, G. C.; Wigmore, S. J.; Ramachandran, P.; Vallejos, C. A.; Carragher, N. O.; Saeidinejad, M. M.; Quaglia, A.; Jalan, R.; Simpson, K. J.; Kendall, T. J.; Rule, J. A.; Lee, W. M.; Hoare, M.; Weston, C. J.; Marioni, J. C.; Teichmann, S. A.; Bird, T. G.; Carlin, L. M.; Henderson, N. C.
作者单位：University of Edinburgh; University of Edinburgh; University of Edinburgh; Beatson Institute; University of Edinburgh; Royal Infirmary of Edinburgh; University of Edinburgh; Karolinska Institutet; Alan Turing Institute; University of Edinburgh; University of London; University College London; University of London; University College London; Royal Free London NHS Foundation Trust; University of London; University College London; University of Edinburgh; University of Texas System; University of Texas Southwestern Medical Center; University of Cambridge; University of Cambridge; University of Birmingham; University of Birmingham; University of Birmingham; Cancer Research UK; University of Cambridge; CRUK Cambridge Institute; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Wellcome Trust Sanger Institute; University of Cambridge; University of Glasgow; University of Edinburgh
摘要：The liver has a unique ability to regenerate(1,2); however, in the setting of acute liver failure (ALF), this regenerative capacity is often overwhelmed, leaving emergency liver transplantation as the only curative option(3-5). Here, to advance understanding of human liver regeneration, we use paired single-nucleus RNA sequencing combined with spatial profiling of healthy and ALF explant human livers to generate a single-cell, pan-lineage atlas of human liver regeneration. We uncover a novel A...
