作者：Niepoth, Natalie; Merritt, Jennifer R.; Uminski, Michelle; Lei, Emily; Esquibies, Victoria S.; Bando, Ina B.; Hernandez, Kimberly; Gebhardt, Christoph; Wacker, Sarah A.; Lutzu, Stefano; Poudel, Asmita; Soma, Kiran K.; Rudolph, Stephanie; Bendesky, Andres
作者单位：Columbia University; Columbia University; Manhattan University; Yeshiva University; Yeshiva University; University of British Columbia; University of British Columbia
摘要：Cell types with specialized functions fundamentally regulate animal behaviour, and yet the genetic mechanisms that underlie the emergence of novel cell types and their consequences for behaviour are not well understood1. Here we show that the monogamous oldfield mouse (Peromyscus polionotus) has recently evolved a novel cell type in the adrenal gland that expresses the enzyme AKR1C18, which converts progesterone into 20 alpha-hydroxyprogesterone. We then demonstrate that 20 alpha-hydroxyproges...
作者：Petersen, Jonas; Ludwig, Mette Q.; Juozaityte, Vaida; Ranea-Robles, Pablo; Svendsen, Charlotte; Hwang, Eunsang; Kristensen, Amalie W.; Fadahunsi, Nicole; Lund, Jens; Breum, Alberte W.; Mathiesen, Cecilie V.; Sachs, Luisa; Moreno-Justicia, Roger; Rohlfs, Rebecca; Ford, James C.; Douros, Jonathan D.; Finan, Brian; Portillo, Bryan; Grose, Kyle; Petersen, Jacob E.; Trauelsen, Mette; Feuchtinger, Annette; DiMarchi, Richard D.; Schwartz, Thue W.; Deshmukh, Atul S.; Thomsen, Morten B.; Kohlmeier, Kristi A.; Williams, Kevin W.; Pers, Tune H.; Frlound, Bente; Stromgaard, Kristian; Klein, Anders B.; Clemmensen, Christoffer
作者单位：Novo Nordisk Foundation; University of Copenhagen; University of Copenhagen; University of Texas System; University of Texas Southwestern Medical Center; Indiana University System; Indiana University Bloomington; University of Copenhagen
摘要：The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel that is critical to many processes in the brain. Genome-wide association studies suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity are important for body weight homeostasis(1). Here we report the engineering and preclinical development of a bimodal molecule that integrates NMDA receptor antagonism with glucagon-like peptide-1 (GLP-1) receptor agonism to effectively reverse...
作者：Dirnberger, Florian; Quan, Jiamin; Bushati, Rezlind; Diederich, Geoffrey M.; Florian, Matthias; Klein, Julian; Mosina, Kseniia; Sofer, Zdenek; Xu, Xiaodong; Kamra, Akashdeep; Garcia-Vidal, Francisco J.; Alu, Andrea; Menon, Vinod M.
作者单位：City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City College of New York (CUNY); University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Massachusetts Institute of Technology (MIT); University of Chemistry & Technology, Prague; Autonomous University of Madrid
作者：Levison, Harold F.; Marchi, Simone; Noll, Keith S.; Spencer, John R.; Statler, Thomas S.; Bell, James F.; Bierhaus, Edward B.; Binzel, Richard; Bottke, William F.; Britt, Daniel; Brown, Michael E.; Buie, Marc W.; Christensen, Philip R.; Dello Russo, Neil; Emery, Joshua P.; Grundy, William M.; Hahn, Matthias; Hamilton, Victoria E.; Howett, Carly; Kaplan, Hannah; Kretke, Katherine; Lauer, Tod R.; Manzoni, Claudia; Marschall, Raphael; Martin, Audrey C.; May, Brian H.; Mottola, Stefano; Olkin, Catherine B.; Paetzold, Martin; Parker, Joel Wm.; Porter, Simon; Preusker, Frank; Protopapa, Silvia; Reuter, Dennis C.; Robbins, Stuart J.; Salmon, Julien; Simon, Amy A.; Stern, S. Alan; Sunshine, Jessica M.; Wong, Ian; Weaver, Harold A.; Adam, Coralie; Ancheta, Shanti; Andrews, John; Anwar, Saadat; Barnouin, Olivier S.; Beasley, Matthew; Berry, Kevin E.; Birath, Emma; Bolin, Bryce; Booco, Mark; Burns, Rich; Campbell, Pam; Carpenter, Russell; Crombie, Katherine; Effertz, Mark; Eifert, Emily; Ellis, Caroline; Faiks, Preston; Fischetti, Joel; Fleming, Paul; Francis, Kristen; Franco, Ray; Freund, Sandy; Gallagher, Claire; Geeraert, Jeroen; Gobat, Caden; Gorgas, Donovan; Granat, Chris; Gray, Sheila; Haas, Patrick; Harch, Ann; Hegedus, Katie; Isabelle, Chris; Jackson, Bill; Jacob, Taylor; Jennings, Sherry; Kaufmann, David; Keeney, Brian A.; Kennedy, Thomas; Lauffer, Karl; Lessac-Chenen, Erik; Leonard, Rob; Levine, Andrew; Lunsford, Allen; Martin, Tim; Mcadams, Jim; Mehall, Greg; Merkley, Trevor; Miller, Graham; Montanaro, Matthew; Montgomery, Anna; Murphy, Graham; Myers, Maxwell; Nelson, Derek S.; Ocampo, Adriana; Olds, Ryan; Pelgrift, John Y.; Perkins, Trevor; Pineau, Jon; Poland, Devin; Ramanan, Vaishnavi; Rose, Debi; Sahr, Eric; Short, Owen; Solanki, Ishita; Stanbridge, Dale; Sutter, Brian; Talpas, Zachary; Taylor, Howard; Treiu, Bo; Vermeer, Nate; Vincent, Michael; Wallace, Mike; Weigle, Gerald; Wibben, Daniel R.; Wiens, Zach; Wilson, John P.; Zhao, Yifan
作者单位：Southwest Research Institute; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); Mary W. Jackson NASA Headquarters; Arizona State University; Arizona State University-Tempe; Massachusetts Institute of Technology (MIT); State University System of Florida; University of Central Florida; California Institute of Technology; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; Northern Arizona University; University of Cologne; University of Oxford; Universite Cote d'Azur; Observatoire de la Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Helmholtz Association; German Aerospace Centre (DLR); University System of Maryland; University of Maryland College Park; American University; Cornell University; Rochester Institute of Technology
摘要：Asteroids with diameters less than about 5 km have complex histories because they are small enough for radiative torques (that is, YORP, short for the Yarkovsky-O'Keefe-Radzievskii-Paddack effect) 1 to be a notable factor in their evolution 2 . (152830) Dinkinesh is a small asteroid orbiting the Sun near the inner edge of the main asteroid belt with a heliocentric semimajor axis of 2.19 au; its S-type spectrum 3,4 is typical of bodies in this part of the main belt 5 . Here we report observatio...
