Nature

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• Molecular basis for differential Igk versus Igh V(D)J joining mechanisms AI翻译
  作者：Zhang, Yiwen; Li, Xiang; Ba, Zhaoqing; Lou, Jiangman; Gaertner, K. Elyse; Zhu, Tammie; Lin, Xin; Ye, Adam Yongxin; Alt, Frederick W.; Hu, Hongli
  作者单位：Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; National Institute of Biological Sciences, Beijing; University of Copenhagen; Georgetown University
  摘要：In developing B cells, V(D)J recombination assembles exons encoding IgH and Ig kappa variable regions from hundreds of gene segments clustered across Igh and Igk loci. V, D and J gene segments are flanked by conserved recombination signal sequences (RSSs) that target RAG endonuclease(1). RAG orchestrates Igh V(D)J recombination upon capturing a J(H)-RSS within the J(H)-RSS-based recombination centre(1-3) (RC). J(H)-RSS orientation programmes RAG to scan upstream D- and V-H-containing chromatin...
• Large-scale plasma proteomics comparisons through genetics and disease associations (vol 622, pg 348, 2023) AI翻译
  作者：Eldjarn, Grimur Hjorleifsson; Ferkingstad, Egil; Lund, Sigrun H.; Helgason, Hannes; Magnusson, Olafur Th.; Gunnarsdottir, Kristbjorg; Olafsdottir, Thorunn A.; Halldorsson, Bjarni V.; Olason, Pall I.; Zink, Florian; Gudjonsson, Sigurjon A.; Sveinbjornsson, Gardar; Magnusson, Magnus I.; Helgason, Agnar; Oddsson, Asmundur; Halldorsson, Gisli H.; Magnusson, Magnus K.; Saevarsdottir, Saedis; Eiriksdottir, Thjodbjorg; Masson, Gisli; Stefansson, Hreinn; Jonsdottir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Melsted, Pall; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Thorleifsson, Gudmar; Ulfarsson, Magnus O.; Gudbjartsson, Daniel F.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari
  作者单位：Decode Genetics; University of Iceland; Reykjavik University; University of Iceland; University of Iceland; University of Iceland
• Dispersion-assisted high-dimensional photodetector AI翻译
  作者：Fan, Yandong; Huang, Weian; Zhu, Fei; Liu, Xingsi; Jin, Chunqi; Guo, Chenzi; An, Yang; Kivshar, Yuri; Qiu, Cheng-Wei; Li, Wei
  作者单位：Chinese Academy of Sciences; Changchun Institute of Optics, Fine Mechanics & Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National University of Singapore; Australian National University; Harbin Engineering University
  摘要：Intensity, polarization and wavelength are intrinsic characteristics of light. Characterizing light with arbitrarily mixed information on polarization and spectrum is in high demand(1-4). Despite the extensive efforts in the design of polarimeters(5-18) and spectrometers(19-27), concurrently yielding high-dimensional signatures of intensity, polarization and spectrum of the light fields is challenging and typically requires complicated integration of polarization- and/or wavelength-sensitive e...
• OZEMPIC KEEPS WOWING: TRIAL DATA SHOW BENEFITS FOR KIDNEY DISEASE AI翻译
  作者：Fairbank, Rachel
  摘要：Semaglutide, the same compound in obesity drug Wegovy, slashes risk of kidney failure and death for people with diabetes.
• Photocatalytic doping of organic semiconductors AI翻译
  作者：Jin, Wenlong; Yang, Chi-Yuan; Pau, Riccardo; Wang, Qingqing; Tekelenburg, Eelco K.; Wu, Han-Yan; Wu, Ziang; Jeong, Sang Young; Pitzalis, Federico; Liu, Tiefeng; He, Qiao; Li, Qifan; Huang, Jun-Da; Kroon, Renee; Heeney, Martin; Woo, Han Young; Mura, Andrea; Motta, Alessandro; Facchetti, Antonio; Fahlman, Mats; Loi, Maria Antonietta; Fabiano, Simone
  作者单位：Linkoping University; University of Groningen; University of Cagliari; Korea University; Linkoping University; Imperial College London; Imperial College London; Sapienza University Rome; University System of Georgia; Georgia Institute of Technology
  摘要：Chemical doping is an important approach to manipulating charge-carrier concentration and transport in organic semiconductors (OSCs)(1-3) and ultimately enhances device performance(4-7). However, conventional doping strategies often rely on the use of highly reactive (strong) dopants(8-10), which are consumed during the doping process. Achieving efficient doping with weak and/or widely accessible dopants under mild conditions remains a considerable challenge. Here, we report a previously undes...
• China seeks global impact and recognition AI翻译
  作者：Baker, Simon
• Lack of cannabis research boosts misinformation AI翻译
  作者：Torkamaneh, Davoud
  作者单位：Laval University
• Exclusive: How NASA astronauts are training to walk on the Moon in 2026 AI翻译
  作者：Witze, Alexandra
  摘要：Simulated lunar exploration in an Arizona volcanic field this month helped astronauts to prepare for doing geology in harsh conditions at the lunar south pole. Nature joined mission control.
• Chinese science still has room to grow AI翻译
  作者：Wu, Bo; Baker, Simon; Crew, Bec; Maxwell, Tanner
• Negotiating a pandemic treaty is just the first step - how will countries comply? AI翻译
  作者：Park, Tae Jung
  作者单位：Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Governments must act now on vaccine and pathogen-sample sharing, or any agreement will be a promise only on paper.