Nature

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• Found at last: long-lost branch of the Nile that ran by the pyramids AI翻译
  作者：Kreier, Freda
  摘要：Geological survey reveals the remains of a major waterway that ancient Egyptian builders could have used to transport materials.
• Time-resolved cryo-EM of G-protein activation by a GPCR AI翻译
  作者：Papasergi-Scott, Makaia M.; Perez-Hernandez, Guillermo; Batebi, Hossein; Gao, Yang; Eskici, Goezde; Seven, Alpay B.; Panova, Ouliana; Hilger, Daniel; Casiraghi, Marina; He, Feng; Maul, Luis; Gmeiner, Peter; Kobilka, Brian K.; Hildebrand, Peter W.; Skiniotis, Georgios
  作者单位：Stanford University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Leipzig University; Philipps University Marburg; University of Milan; University of Erlangen Nuremberg; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Stanford University
  摘要：G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating guanine nucleotide exchange in the G alpha subunit1. To visualize this mechanism, we developed a time-resolved cryo-EM approach that examines the progression of ensembles of pre-steady-state intermediates of a GPCR-G-protein complex. By monitoring the transitions of the stimulatory Gs protein in complex with the beta 2-adrenergic receptor at short sequential time points after GTP addition, we identified the c...
• Cancer treatment AI翻译
  作者：Brody, Herb
• US halts funding to controversial virus-hunting group: what researchers think AI翻译
  作者：Lenharo, Mariana
  摘要：Some scientists think the decision regarding EcoHealth Alliance is fair; others say it might negatively affect virus surveillance.
• Nature's message to South Africa's next government: talk to your researchers AI翻译
  作者：[Anonymous]
  摘要：The young nation faces some deep-rooted challenges. Solutions informed by science could make a difference.
• Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice AI翻译
  作者：Wang, Gang; Chen, Xi; Yu, Chengzhi; Shi, Xiaobao; Lan, Wenxian; Gao, Chaofeng; Yang, Jun; Dai, Huiling; Zhang, Xiaowei; Zhang, Huili; Zhao, Boyu; Xie, Qi; Yu, Nan; He, Zuhua; Zhang, Yu; Wang, Ertao
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fujian Agriculture & Forestry University; Shanghai Normal University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; ShanghaiTech University
  摘要：Plant pattern-recognition receptors perceive microorganism-associated molecular patterns to activate immune signalling(1,2). Activation of the pattern-recognition receptor kinase CERK1 is essential for immunity, but tight inhibition of receptor kinases in the absence of pathogen is crucial to prevent autoimmunity(3,4). Here we find that the U-box ubiquitin E3 ligase OsCIE1 acts as a molecular brake to inhibit OsCERK1 in rice. During homeostasis, OsCIE1 ubiquitinates OsCERK1, reducing its kinas...
• Changemaker: Freeman Hrabowski AI翻译
  作者：Gewin, Virginia; Hrabowski, Freeman
• Quantum tunnelling of electrons brings ultrafast optical microscopy to the atomic scale AI翻译
  作者：Siday, Thomas; Huber, Rupert
  作者单位：University of Regensburg
  摘要：The oscillating electromagnetic fields that carry light can cause electrons to tunnel back and forth through a potential energy barrier. Remarkably, this alternating current can coherently emit measurable light waves - an unexpected process that can be exploited to build an optical microscope that undercuts existing spatial and temporal limitations.
• AI's English-language bias is cultural bias, too AI翻译
  作者：Luo, Queenie; Puett, Michael
  作者单位：Harvard University
• Why snow is crucial for water supply AI翻译
  作者：Ryberg, Karen R.