-
作者：Wanie, Vincent; Bloch, Etienne; Mansson, Erik P.; Colaizzi, Lorenzo; Ryabchuk, Sergey; Saraswathula, Krishna; Ordonez, Andres F.; Ayuso, David; Smirnova, Olga; Trabattoni, Andrea; Blanchet, Valerie; Ben Amor, Nadia; Heitz, Marie-Catherine; Mairesse, Yann; Pons, Bernard; Calegari, Francesca
作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Universite de Bordeaux; CEA; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); University of Hamburg; University of Hamburg; Imperial College London; Leibniz Association; Max Born Institute for Nonlinear Optics & Short Term Spectroscopy; Technical University of Berlin; Leibniz University Hannover; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Polytechnic University of Milan; University of London; Queen Mary University London
摘要：Chiral molecules, used in applications such as enantioselective photocatalysis(1), circularly polarized light detection(2) and emission(3) and molecular switches(4,5), exist in two geometrical configurations that are non-superimposable mirror images of each other. These so-called (R) and (S) enantiomers exhibit different physical and chemical properties when interacting with other chiral entities. Attosecond technology might enable influence over such interactions, given that it can probe and ...
-
作者：Choksi, Semil P.; Byrnes, Lauren E.; Konjikusic, Mia J.; Tsai, Benedict W. H.; Deleon, Rachel; Lu, Quanlong; Westlake, Christopher J.; Reiter, Jeremy F.
作者单位：University of California System; University of California San Francisco; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Chan Zuckerberg Initiative (CZI)
摘要：The canonical mitotic cell cycle coordinates DNA replication, centriole duplication and cytokinesis to generate two cells from one(1). Some cells, such as mammalian trophoblast giant cells, use cell cycle variants like the endocycle to bypass mitosis(2). Differentiating multiciliated cells, found in the mammalian airway, brain ventricles and reproductive tract, are post-mitotic but generate hundreds of centrioles, each of which matures into a basal body and nucleates a motile cilium(3,4). Seve...
-
作者：Xu, Hanwen; Usuyama, Naoto; Bagga, Jaspreet; Zhang, Sheng; Rao, Rajesh; Naumann, Tristan; Wong, Cliff; Gero, Zelalem; Gonzalez, Javier; Gu, Yu; Xu, Yanbo; Wei, Mu; Wang, Wenhui; Ma, Shuming; Wei, Furu; Yang, Jianwei; Li, Chunyuan; Gao, Jianfeng; Rosemon, Jaylen; Bower, Tucker; Lee, Soohee; Weerasinghe, Roshanthi; Wright, Bill J.; Robicsek, Ari; Piening, Brian; Bifulco, Carlo; Wang, Sheng; Poon, Hoifung
作者单位：Microsoft; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Digital pathology poses unique computational challenges, as a standard gigapixel slide may comprise tens of thousands of image tiles(1-3). Prior models have often resorted to subsampling a small portion of tiles for each slide, thus missing the important slide-level context(4). Here we present Prov-GigaPath, a whole-slide pathology foundation model pretrained on 1.3 billion 256x256 pathology image tiles in 171,189 whole slides from Providence, a large US health network comprising 28 cancer cen...
-
作者：Callaway, Ewen
摘要：Bacterial defensive systems scramble the standard workflow of life.
-
作者：Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
作者单位：European Molecular Biology Laboratory (EMBL); Swiss Institute Experimental Cancer Research; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); European Molecular Biology Laboratory (EMBL); University of Groningen
摘要：Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis 1,2 . Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural im...
-
作者：Elhatisari, Serdar; Bovermann, Lukas; Ma, Yuan-Zhuo; Epelbaum, Evgeny; Frame, Dillon; Hildenbrand, Fabian; Kim, Myungkuk; Kim, Youngman; Krebs, Hermann; Laehde, Timo A.; Lee, Dean; Li, Ning; Lu, Bing-Nan; Meissner, Ulf-G.; Rupak, Gautam; Shen, Shihang; Song, Young-Ho; Stellin, Gianluca
作者单位：Gaziantep Islam Science & Technology University; Helmholtz Association; University of Bonn; University of Bonn; Ruhr University Bochum; Michigan State University; Michigan State University; South China Normal University; Helmholtz Association; Research Center Julich; Institute for Basic Science - Korea (IBS); Sun Yat Sen University; Chinese Academy of Engineering Physics; Ivane Javakhishvili Tbilisi State University; Mississippi State University; Mississippi State University; Institute for Basic Science - Korea (IBS); Universite Paris Saclay
摘要：Ab initio calculations have an essential role in our fundamental understanding of quantum many-body systems across many subfields, from strongly correlated fermions(1-3) to quantum chemistry(4-6) and from atomic and molecular systems(7-9) to nuclear physics(10-14). One of the primary challenges is to perform accurate calculations for systems where the interactions may be complicated and difficult for the chosen computational method to handle. Here we address the problem by introducing an appro...
-
作者：Crow, James Mitchell
-
作者：Nuwer, Rachel
-
作者：Belli, Sirio; Park, Minjung; Davies, Rebecca L.; Mendel, J. Trevor; Johnson, Benjamin D.; Conroy, Charlie; Benton, Chloe; Bugiani, Letizia; Emami, Razieh; Leja, Joel; Li, Yijia; Maheson, Gabriel; Mathews, Elijah P.; Naidu, Rohan P.; Nelson, Erica J.; Tacchella, Sandro; Terrazas, Bryan A.; Weinberger, Rainer
作者单位：University of Bologna; Smithsonian Institution; Swinburne University of Technology; Australian National University; Australian National University; University of Colorado System; University of Colorado Boulder; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Cambridge; University of Cambridge; Massachusetts Institute of Technology (MIT); Columbia University; Leibniz Association; Leibniz Institut fur Astrophysik Potsdam (AIP)
摘要：Large-scale outflows driven by supermassive black holes are thought to have a fundamental role in suppressing star formation in massive galaxies. However, direct observational evidence for this hypothesis is still lacking, particularly in the young universe where star-formation quenching is remarkably rapid(1-3), thus requiring effective removal of gas(4) as opposed to slow gas heating(5,6). Although outflows of ionized gas are frequently detected in massive distant galaxies(7), the amount of ...
-
作者：Mccabe, Stefan D.; Ferrari, Diogo; Green, Jon; Lazer, David M. J.; Esterling, Kevin M.
作者单位：George Washington University; University of California System; University of California Riverside; Duke University; Northeastern University; Harvard University; University of California System; University of California Riverside
摘要：The social media platforms of the twenty-first century have an enormous role in regulating speech in the USA and worldwide1. However, there has been little research on platform-wide interventions on speech2,3. Here we evaluate the effect of the decision by Twitter to suddenly deplatform 70,000 misinformation traffickers in response to the violence at the US Capitol on 6 January 2021 (a series of events commonly known as and referred to here as 'January 6th'). Using a panel of more than 500,000...
