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作者：Deutsch, Matthew J.; Selinger, Robin L. B.; van der Schoot, Paul
作者单位：University System of Ohio; Kent State University; Kent State University Kent; Kent State University Salem; University System of Ohio; Kent State University; Kent State University Kent; Kent State University Salem; Eindhoven University of Technology
摘要：Liquid crystal mesophases of achiral molecules are normally achiral, yet in a few materials they spontaneously segregate and form right- and left-handed chiral domains. One mechanism that drives chiral segregation is molecular shape fluctuations between axial chiral conformations, where molecular interactions favor matching chirality and promote helical twist. Cooperative chiral ordering may also play a role in chirality amplification, as when a tiny fraction of chiral dopant drives a nematic ...
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作者：Knopper, Konrad; Rao, Anshul; An, Jinping; Cyster, Jason G.
作者单位：Howard Hughes Medical Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Dendritic cell (DC) migration is critical for initiating adaptive immune responses. Previous work suggested a role for ATP-binding cassette transporter C1 (ABCC1) in skin DC migration following cutaneous fluorescein isothiocyanate (FITC) exposure, but the precise mechanism involved was unclear. Here, we establish that the primary contribution ofABCC1 to skin DC function following FITC exposure is not modulation of migration, but enhancement of survival. Our findings demonstrate that ABCC1 oper...
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作者：Liu, Xuyang; Cai, Wensheng; Fu, Haohao; Shao, Xueguang
作者单位：Nankai University; Nankai University; Haihe Laboratory of Sustainable Chemical Transformations
摘要：Revealing the complex mechanisms of protein folding, including the transient intermediate states that govern the process, is a fundamental goal in computational biophysics. While molecular dynamics (MD) simulations generate vast amounts of data to this end, extracting a clear kinetic model from these complex, high-dimensional trajectories remains a significant challenge. We present AI-Based conditional transition clustering (CTC), a framework for analyzing MD trajectories that directly address...
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作者：Zheng, Aiqiu; Yu, Dan; Meng, Xin; Gong, Shumin; Ye, Jiale; Zhou, Hui; Chen, Mo; An, Shuming; Ma, Jun; Li, Can; Cao, Jun - Li; Wu, Kunwei
作者单位：Xuzhou Medical University; Xuzhou Medical University; Xuzhou Medical University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
摘要：Exposure therapy for anxiety disorders relies on fear extinction to reduce pathological fear responses. Here, we show that while effective at diminishing conditioned fear, extinction training paradoxically enhances fear generalization to safe stimuli through activation of the locus coeruleus-dentate gyrus (LC-DG) noradrenergic circuit. Specifically, LC norepinephrine release during extinction stimulates DG GABAergic neurons via beta 1-adrenergic receptors, engaging a PKA/CREB-dependent signali...
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作者：Bai, Xiaoli; Li, Zhefei; Chen, Beibei; Qian, Xun; Guo, Yu; Wang, Qian; Chen, Chun; Chen, Weimin; Shen, Xihui; Liu, Jialin; Jin, Juan; Zhang, Weiqin; Liu, Qi; Chen, Shi; Yang, Shanshan; Xu, Leilei; van der Heijden, Marcel G. A.; Tiedje, James M.; Jiao, Shuo; Wei, Gehong
作者单位：Northwest A&F University - China; Swiss Federal Research Station Agroscope; University of Zurich; Michigan State University
摘要：The rhizosphere microbiome plays a crucial role in the resistance to soilborne plant diseases. However, the principles needed to explain and predict which microbiota will be effective against soilborne pathogens are still lacking due to the complexity of the soil microbial community. We hypothesized that, independent of particular microbial strains, a high diversity is associated with, or increases the probability of, effective suppression. We tested this hypothesis by demonstrating that rando...
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作者：Cheng, Weihao; Yu, Zekai
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作者：Huang, Yuting; Manafirad, Arash; Matoori, Simon; Arriaga, Laura R.; Sun, Sijie; Chen, Anqi; Yang, Xin; Dinsmore, Anthony D.; Mooney, David J.; Weitz, David A.
作者单位：Harvard University; University of Massachusetts System; University of Massachusetts Amherst; Universite de Montreal; Harvard University; Autonomous University of Madrid; Autonomous University of Madrid; Kansas State University; Harvard University
摘要：Lipid vesicles consist of aqueous cores surrounded by a bilayer of phospholipids. Hybrid polymer-lipid vesicles incorporate both polymers and lipids, offering promising properties for developing pharmaceuticals, biosensors, and artificial cells. The hybrid vesicles can be symmetric, with two leaflets of identical compositions, or asymmetric, in with leaflets of dissimilar compositions, which can lead to dramatically altered properties. However, existing methods for producing symmetric and asym...
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作者：Roh, Hyun Woong; Seo, Sang Won; Choi, Seong Hye; Kim, Eun - Joo; Cho, Soo Hyun; Kim, Byeong C.; Choi, Jin Wook; An, Young - Sil; Kim, Na - Rae; Park, Bumhee; Lee, Sun Min; Moon, So Young; Lee, Dongha; Hong, Chang Hyung; Son, Sang Joon; Kim, Eun Young
作者单位：Ajou University; Ajou University; Ajou University; Sungkyunkwan University (SKKU); Samsung Medical Center; Inha University; Pusan National University; Pusan National University Hospital; Chonnam National University; Chonnam National University Hospital; Ajou University; Ajou University; Ajou University; Ajou University; Korea Brain Research Institute (KBRI); Ajou University
摘要：Circadian rhythm disruption is recognized as a feature of aging and neurodegenerative disease, yet whether intrinsic cellular circadian properties relate to underlying processes in humans remains unknown. We measured intrinsic circadian period and its deviation from 24 h (o-period) using ex vivo bioluminescence in dermal fibroblasts from 135 older adults with cognitive complaints. Associations with plasma biomarkers (pTau-217, neurofilament light chain [NfL], and glial fibrillary acidic protei...
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作者：Lilova, Kristina; Subramani, Tamilarasan; Montini, Isabella; Harrison, Anne; Scharrer, Manuel; Wu, Jun; Xu, Hongwu; Navrotsky, Alexandra
作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Oregon State University; Arizona State University; Arizona State University-Tempe; University of Tennessee System; University of Tennessee Knoxville
摘要：Molecular organization at the nano- bio interface governing the colloidal stability, reactivity, immune recognition, and drug delivery performance of nanoparticles remains difficult to predict. Quantifying the primary hydration energetics of biomolecule- coated nanomaterials can determine those interactions and provide a basis for engineered nanocarriers with tailored behavior in biological systems. Here, we measured the thermodynamics of water adsorption on patchy dry magnetite (Fe3O4) nanopa...
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作者：Pan, Hui; Shen, Zhe; Zhao, Liwei; Liu, Peng; Jin, Ziqi; Piard, Eleonore; Xue, Enfu; Lambertucci, Flavia; Stoll, Gautier; Carbonnier, Vincent; Montegut, Lea; Forveille, Sabrina; Maiuri, Maria Chiara; Kepp, Oliver; Zitvogel, Laurence; Ma, Yuting; Martins, Isabelle; Kroemer, Guido
作者单位：Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; UNICANCER; Gustave Roussy; Sichuan University; Universite Paris Saclay; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Systems Medicine - CAMS; Peking Union Medical College; Universite Paris Saclay; UNICANCER; Institut National de la Sante et de la Recherche Medicale (Inserm); Gustave Roussy; UNICANCER; Universite PSL; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut Curie; MINES ParisTech; University of Naples Federico II; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP
摘要：Glucocorticoids (GCs) are potent immunosuppressive agents that compromise anticancer immune responses, yet the molecular mediators of this effect remain incompletely understood. Here, we identify the acyl-CoA-binding protein/diazepam-binding inhibitor (ACBP/DBI) as a critical effector of the GC-induced suppression of tumor immunosurveillance and immunotherapy efficacy. Using orthotopic murine models of breast cancer, non-small cell lung cancer, and cutaneous fibrosarcoma, we show that corticos...
