10期

最新文章

• ADAR-GPT: Learning the language of the epitranscriptome AI翻译
  作者：Wang, Siqi; Fraser, Anna; Xiao, Xinshu
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
• Saturation of superconductivity in cuprates overdoped with high pressure oxygen: Phase diagram with YBa2Cu3O7+δ, δ → 1- AI翻译
  作者：Conradson, Steven D.; Dezaneti, Luiz M.; Baldinozzi, Gianguido; Sederholm, Linda; Karppinen, Maarit; Casillas-Trujillo, Luis; Latimer, Matthew; Mueller, Oliver; Gilioli, Edmondo; Bishop, Alan R.; Liu, Juejing; Guo, Xiaofeng; Pacheco, Juan Lezama
  作者单位：Washington State University; Instituto Federal de Goias (IFG); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Aalto University; Linkoping University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Consiglio Nazionale delle Ricerche (CNR); Istituto dei Materiali per l'Elettronica ed il Magnetismo (IMEM-CNR); United States Department of Energy (DOE); Los Alamos National Laboratory; Stanford University
  摘要：High temperature superconductivity (HTSC) typically occurs as a dome over a narrow range of doping in its phase diagram. The reaction ofYBa2Cu3O7 with Ag2O2 at >= 800 degrees C and 6 GPa inserts oxygen atoms between the Cu1 sites to form tetragonal YBa2Cu3O8 without significant changes to its overall structure or interatomic distances. The superconductivity inYBa2Cu3O8 is essentially unaffected, with the reduction of the transition temperature by <= 2 K and its superconducting fraction by <= 1...
• Reactivation of the silenced BASP1 gene suppresses oncogenic WNT signaling in human colorectal cancer cells AI翻译
  作者：Weber, Leonie I.; Timpen, Lea E.; Egger-Horschinger, Anna-Sophia; Schopf, Philemon; Ayhan, Nesin D.; Demmel, David; Hotze, Madlen; Zhang, Yang; Mehrabi, Mahdi; Puglisi, Kane; Stefan, Eduard; Ghaffari-Tabrizi-Wizsy, Nassim; Ramos, Jose M.; Kwiatkowski, Marcel; Hartl, Markus
  作者单位：University of Innsbruck; University of Innsbruck; Medical University of Graz; University of Innsbruck
  摘要：Starting from human colon cancer cells showing aberrant WNT/f3-catenin/TCF signaling, hyperactivated MYC, and silenced BASP1, we generated stable cell lines overexpressing BASP1, either ectopically, or by reactivating the dormant BASP1 promoter using a lentiviral CRISPR-based system. BASP1 encodes a neuronal signaling protein and transcriptional corepressor, from which tumor-suppressive functions have been described in avian cell systems and in multiple human cancer cell types. Proteome and tr...
• SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study AI翻译
  作者：Chia, Pou Hong Justin; Toyonaga, Takuya; Tong, Junchao; Le, Hannah; Dias, Mark; Boyle, Amanda J.; Raymond, Roger; Longbrake, Erin E.; Huang, Yiyun; Carson, Richard E.; Airas, Laura; Vasdev, Neil; Chen, Ming - Kai; Zheng, Chao
  作者单位：University of Toronto; Centre for Addiction & Mental Health - Canada; University of Toronto; Yale University; University of Toronto; Yale University; University of Turku; University of Toronto
  摘要：Synaptic loss is increasingly recognized as a key pathological feature in multiple sclerosis (MS), contributing to disease progression and cognitive dysfunction. Synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) imaging has emerged as a promising tool for quantifying synaptic density in vivo. Here, we used the clinically translatable tracer [18F]SynVesT- 1 to comprehensively characterize synaptic density across the brain and spinal cord in the experimental autoimmune e...
• Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement- dependent mechanism AI翻译
  作者：Howard, Mark C.; Farrar, Conrad A.; Nauser, Christopher L.; Jeon, Yusun; Polycarpou, Anastasia; Smolarek, Dorota; Greenlaw, Roseanna; Foster, Martyn; Garred, Peter; Vizitiu, Daniela A.; Mukhopadhyay, Subhankar; Sacks, Steven H.
  作者单位：University of London; King's College London; University of Copenhagen; Rigshospitalet
  摘要：The human developmental disorder 3MC syndrome (Malpuech, Michels, Mingarelli, and Carnevale) features skeletal deformities associated with a deficiency of the pattern recognition molecule collectin-11 (CL-11), yet the underlying molecular and cellular mechanisms remain uncertain. Here, we demonstrate that CL-11 deletion alone does not produce skeletal abnormalities in mice; however, combined deficiencies of CL-11 with complement components MASP-2 (lectin pathway), complement factors B, or C3 (...
• Head- to- head comparison of brain- derived pTau217 and total pTau217 for brain amyloid and tau pathology classification AI翻译
  作者：Jiang, Yuanbing; Zheng, Wenyue; Xia, Zengjie; Wong, Wan Wa; Cheng, Lily K. W.; Ip, Fanny C.; Choi, Siu Man; Chan, Andrew L. T.; Lam, Ching Yu; Ho, Ka Shing; Shum, Chun Keung; Yuen, Jacqueline K. Y.; Shea, Yat Fung; Wai, Hok Man; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Y.; Wong, Hiu Yi; Zetterberg, Henrik; Fu, Amy K. Y.; Ip, Nancy Y.
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Queen Elizabeth Hospital - Hong Kong; Tuen Mun Hospital; University of Hong Kong; United Christian Hospital; Chinese University of Hong Kong; Chinese University of Hong Kong; University of London; University College London; University of Gothenburg; Sahlgrenska University Hospital; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Indian Institute of Science (IISC) - Bangalore; Hong Kong University of Science & Technology
  摘要：Phosphorylated-tau 217 (pTau217) is currently the most promising blood-based biomarker for accurately detecting Alzheimer's disease (AD) pathology. However, interference from peripheral tau species in the kidneys or peripheral nerves can hinder diagnostic precision. Recently developed brain-derived pTau217 (BD-pTau217) assays emerge as highly specific tools for detecting AD-related pathological changes in the brain. In this study, we conducted a head-to-head comparison of the NULISAqpcr BD-pTa...
• Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins (vol. 122, e2424500122, 2025) AI翻译
  作者：Xie, Wanlin; Sun, Weidi; Li, Qin; Dang, Yang; Ma, Lele; Liu, Yuan; Zhang, Hui; Qu, Fengli; Tan, Weihong
• Global analysis of protein degradation reveals instability of diverse regulators in Escherichia coli AI翻译
  作者：MacKrell, Elliot J.; Lomenick, Brett; Qiu, Yanping; Jeckel, Hannah; Jones, Jeff; Chou, Tsui-Fen; Tirrell, David A.
  作者单位：California Institute of Technology; California Institute of Technology; California Institute of Technology; California Institute of Technology
  摘要：Regulated protein degradation underlies the timely execution of essential gene expression programs in bacteria. Here, we deployed time-resolved chemoproteomics, text mining of the PubMed and EcoCyc knowledge bases, and machine learning classification to identify proteolytic regulation in exponential and stationary phase Escherichia coli cultures. We experimentally validated the instability of diverse homeostatic and stress response regulators, including the principal cyclic-di-GMP phosphodiest...
• Aging populations threaten conservation goals of zoos (vol 123, e2522274123, 2026) AI翻译
  作者：Meireles, Joao Pedro; Hahn-Klimroth, Max; Lackey, Laurie Bingaman; van Eeuwijk, Nick; Bertelsen, Mads Frost; Dressen, Severin; Dierkes, Paul Wilhelm; Abraham, Andrew J.; Clauss, Marcus
• Adsorption and reaction of SO2, H2S, and N2O on graphene/ silicon(111): Successful quest for a metal-free catalyst-Theory and experiment AI翻译
  作者：Seif, Abdolvahab; Stach, Thomas; Pham, Trung T.; Uddin, Md Arif; Colomer, Jean-Francois; Sporken, Robert; Ambrosetti, Alberto; Silvestrelli, Pier Luigi; Burghaus, Uwe
  作者单位：University of Padua; University of Turin; North Dakota State University Fargo
  摘要：Graphene supported on Si(111) (short Gr/Si) is one of the very few examples of metal-free carbon catalyst that catalyzes gas-surface reactions. Kinetics measurements indicate dissociation of SO2 and H2S but molecular adsorption of N2O. In addition, spectroscopy revealed adsorbed sulfur after SO2 and H2S adsorption. Experiments were conducted at ultrahigh vacuum conditions, using kinetics techniques [i.e., thermal desorption spectroscopy (TDS)], spectroscopy [Auger electron spectroscopy (AES), ...