10期

最新文章

• The dynamic response of the bacterial flagellar motor to its direct intracellular input signal AI翻译
  作者：Vrabioiu, Alina M.; Hosu, Basarab G.; Samuel, Aravinthan D. T.
  作者单位：Harvard University
  摘要：The bacterial flagellar motor drives bacterial swimming and chemotaxis by rotating helical flagellar filaments. When Escherichia coli navigates chemical gradients, the motor switches from counterclockwise (CCW) during forward swimming to clockwise (CW) during direction-changing tumbles. The motor responds indirectly to extracellular chemosensory input to membrane-bound chemoreceptors using an intervening intracellular signaling pathway. How the motor responds to its direct input signal- the di...
• Convolutional neural networks outperform other presence- only species distribution modeling algorithms AI翻译
  作者：Anand, Akash; Deneu, Benjamin; Radeloff, Volker C.
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：Species distribution models (SDMs) are essential tools for ecologists and conservationists because they can identify environmental determinants of species occurrences and predict species distributions. Unfortunately, most SDM algorithms rely on point- based or localized averages of environmental conditions and do not capture spatial heterogeneity and landscape patterns that shape species distributions. However, species-environment relationships are hierarchical, with different environmental fa...
• Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion AI翻译
  作者：Lee, Eunhye; Kim, Wonju; Beier, David H.; Lee, Yejin; Kovalenko, Marina; Saif, Faaiza; Oliver, Esaria; Srinageshwar, Bhairavi; Murtha, Ryan; Andrew, Marissa A.; Jiang, Andrew; Gillis, Tammy; Demelo, Brigitte; Ruliera, Jayla; Lucente, Diane; Kwak, Seung; Lee, Ramee; Pinto, Ricardo Mouro; Macdonald, Marcy E.; Gusella, James F.; O'brien, Patrick J.; Wheeler, Vanessa C.; Seong, Ihn Sik
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of Michigan System; University of Michigan; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School
  摘要：Huntington's disease (HD) is a fatal neurodegenerative disorder caused by inheriting an expanded CAG repeat tract in the huntingtin gene (HTT) that further expands in somatic cells over an individual's lifetime. Genome-wide association studies have provided critical insight into factors that modify the course of disease. These include DNA repair genes that alter the rate of somatic expansion and other genes that do not appear to directly influence this process. One modifier gene is DNA ligase ...
• Altermagnetic polar metallic phase in ultrathin epitaxially strained RuO2 films AI翻译
  作者：Jeong, Seung Gyo; Choi, In Hyeok; Nair, Sreejith; Buiarelli, Luca; Pourbahari, Bita; Oh, Jin Young; Lin, Bonnie Y. X.; LeBeau, James M.; Bassim, Nabil; Hirai, Daigorou; Seo, Ambrose; Choi, Woo Seok; Fernandes, Rafael M.; Birol, Turan; Zhao, Liuyan; Lee, Jong Seok; Jalan, Bharat
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; Gwangju Institute of Science & Technology (GIST); McMaster University; McMaster University; McMaster University; Sungkyunkwan University (SKKU); Massachusetts Institute of Technology (MIT); Nagoya University; University of Kentucky; University of Minnesota System; University of Minnesota Twin Cities; University of Illinois System; University of Illinois Urbana-Champaign; University of Michigan System; University of Michigan
  摘要：Altermagnetism refers to a wide class of magnetic orders featuring magnetic sublattices with opposite spins related by rotational symmetries, resulting in nontrivial spin splitting and magnetic multipoles. However, the direct observation of the altermagnetic transition remains elusive. Here, by combining theoretical analysis, electrical transport, X-ray, and optical spectroscopies, we establish a phase diagram in hybrid molecular beam epitaxy-grown RuO2/TiO2 (110) films, mapping symmetries alo...
• Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions AI翻译
  作者：Levien, Ethan; Kang, Joon Ho; Biswas, Kuheli; Manalis, Scott R.; Amir, Ariel; Miettinen, Teemu P.
  作者单位：Dartmouth College; Seoul National University (SNU); Seoul National University (SNU); Massachusetts Institute of Technology (MIT); Weizmann Institute of Science; Massachusetts Institute of Technology (MIT); University of London; University College London
  摘要：Cell growth rates exhibit cell-intrinsic cell-to-cell variability, which influences cell fitness and size homeostasis from bacteria to cancer. It remains unclear whether this variability arises from stochasticity in cell growth or division processes, or from cell-size-dependent growth regulation. To separate these potential sources of growth variability, single-cell growth rates need to be examined across different timescales. Here, we study cell size and growth regulation by tracking lymphocy...
• Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint AI翻译
  作者：Senthilkumar, Irish; Vangheel, Jef; Kumar, Vatsal; McNamara, Laoise; Smeets, Bart; Howley, Enda; McEvoy, Eoin
  作者单位：Ollscoil na Gaillimhe-University of Galway; Ollscoil na Gaillimhe-University of Galway; KU Leuven
  摘要：Mechanoresponsive cell proliferation is a feature of growing tumors, despite the suppression of many other regulatory checkpoints in cancer, but the underlying cell-scale mechanisms driving this behavior have not yet been established. In this study, we propose a biophysical model for cell growth as governed by actively controlled osmolarity, which we integrate with a discrete particle framework to simulate growth and remodeling of breast cancer spheroids. Confinement and biomechanical feedback...
• Loss of function of the chromatin remodeling gene INO80D leads to neurogenic features of schizophrenia AI翻译
  作者：Sunshine, Anna B.; Gulsuner, Suleyman; Williams, C. Andrew; Sarchi, Martina; Chen, Robert Y.; Cavanaugh, Christopher; Hesson, Jennifer; Mathieu, Julie; Young, Jessica E.; McClellan, Jon M.; King, Mary -Claire
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Pavia
  摘要：Schizophrenia has been linked to severely damaging de novo mutations in synaptic junction proteins, neurotransmitter receptors, transcription factors, and chromatin remodeling proteins. In a patient with schizophrenia in the absence of a family history of severe mental illness, we identified de novo nonsense mutation, INO80D p.Q568X, associated with both a truncated protein and partial nonsense-mediated decay. Three experiments were undertaken to evaluate the consequences of the mutation. 1) I...
• The DELAYED ABAXIAL TRICHOMES Helitron has dual functions in vegetative and pollen development in Arabidopsis thaliana AI翻译
  作者：Doody, Erin; Zhao, Jianfei; Sharma, Bishwas; Poethig, R. Scott
  作者单位：University of Pennsylvania; University of Cambridge; DePaul University
  摘要：Transposons drive genetic diversity and evolution by altering the genomic landscape over time. Here, we describe DELAYED ABAXIAL TRICHOMES (DAB), a Helitron/ RC transposable element in Arabidopsis thaliana that has a role in vegetative phase change and gametogenesis. A genome-wide association study (GWAS) for the timing of abaxial trichome development (an adult leaf trait) in A. thaliana revealed a conserved haplotype of polymorphisms within DAB that delays abaxial trichome production. CRISPR-...
• NMI promotes the secretion of IL-17 and exacerbates psoriasis AI翻译
  作者：Gao, Yaqi; Wang, Jingjing; Qin, Zhen; Xu, Na; Wang, Xiaowen; Liu, Tianqi; Wang, Shengli; Chen, Zhenxing; Xu, Yunhua; Yao, Yongjie; Wu, Yimiao; Weng, Zhuangfeng; Geng, Yan; Yin, Zhinan; Qin, Jing; Xu, Tao; Liu, Yingfang; Liang, Huanhuan
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Peking University; Jinan University; Jinan University; University of South China
  摘要：Damage-associated molecular patterns (DAMPs) are well established as key mediators of innate immune activation; however, their functions in modulating adaptive immunity, particularly T cell responses, remain incompletely characterized. Here, we report the identification and functional characterization of NMI-a recently identified DAMP-as a regulator of T helper 17 (Th17) cell activity and its involvement in psoriasis pathogen esis. Elevated expression of NMI was observed in psoriatic skin lesi...
• A pharmacovigilance data-driven approach to reveal high fatal adverse events following checkpoint immunotherapy AI翻译
  作者：Sun, Zhen; Deng, Xuan; Guo, Jianglong; Liu, Mengsi; Wang, Siying; Wang, Jian; Zheng, Jiaojiao; Niu, Kongyan; Shen, Weiming; Ye, Zhen; Zheng, Chongming; Wang, Hongye; Yang, Fan; Bao, Zhouzhou; Chan, Kui Ming; Chen, Gang; Guan, Ming; Jin, Haojie
  作者单位：Shanghai Jiao Tong University; Fudan University; Guangdong Academy of Medical Sciences & Guangdong General Hospital; Southern Medical University - China; University of South China; Wenzhou Medical University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; City University of Hong Kong
  摘要：Immune checkpoint inhibitors (ICIs) have significantly improved the outcome of cancer treatment, but they also expose most patients to a variety of treatment-related adverse events (AEs). This study introduces a modified pharmacovigilance approach to identify ICI-related high-mortality AEs, a subset of treatment-related complications that are disproportionately reported with elevated fatality during ICI therapy. Utilizing large-scale pharmacovigilance data from 148,972 ICI-treated cases in the...