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作者：Fresard, Sara; Pangburn, Sarah J.; Leiss, Kayla; Boodwa-Ko, Daphne; Kovacsics, Daniella; Schoenherr, Chris J.; Rabinowitz, Jeremy S.; Economides, Aris N.; Li, Li; Qiu, Weigang; Gonzalez-Baradat, Bernardo; Rosa, Alessandro; Thomson, Russell; Raper, Jayne; Verdi, Joseph
作者单位：City University of New York (CUNY) System; City University of New York (CUNY) System; Hunter College (CUNY); Regeneron
摘要：Some primates are immune to infection by most African trypanosome parasites due to apolipoprotein L-1 (APOL1), a primate-specific ion channel-forming protein. Our long-term objective has been to reduce African trypanosomiasis in livestock by genetic bioengineering of cattle with primate APOL1. To select which primate APOL1, we analyzed Papio ssp. APOL1 proteins and found that Papio hamadryasAPOL1 was a strong candidate for transgenic animal production based on its trypanosome-killing capacity,...
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作者：Katsumura, Takafumi; Sato, Suguru; Yamashita, Kana; Oda, Shoji; Gakuhari, Takashi; Tanaka, Shodai; Fujitani, Kazuko; Nishimaki, Toshiyuki; Imai, Tadashi; Yoshiura, Yasutoshi; Takeshima, Hirohiko; Hashiguchi, Yasuyuki; Sekita, Yoichi; Mitani, Hiroshi; Ogawa, Motoyuki; Takeuchi, Hideaki; Oota, Hiroki
作者单位：Kitasato University; Okayama University; Kyushu University; Kitasato University; University of Tokyo; Kanazawa University; Kitasato University; Japan Fisheries Research & Education Agency (FRA); Fukui Prefectural University; Tokai University; Osaka Medical & Pharmaceutical University; Kitasato University; Tohoku University; University of Tokyo
摘要：Phenotypic plasticity allows organisms to adapt traits in response to environmental changes, yet the molecular basis by which such plastic traits become genetically fixed remains unclear. Here, we investigated gut-length plasticity in medaka fish (Oryzias latipes) through genome-wide methylation profiling, CRISPR/Cas9-mediated deletion, and population genomic analyses. We found that seasonal methylation of CpG sites upstream of the Plxnb3 is correlated with gut-length plasticity, and deletion ...
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作者：Morgenstern, Travis J.; Ota, Naruhisa; Lin, Zhonghua; Lechermann, Laura M.; Gill, Herman; Ogasawara, Annie; Williams, Simon; Marroquin, Kevin A.; Scherl, Alexis; Davies, Christopher W.; Byrnes, James R.; Seshasayee, Dhaya; Koerber, James T.
作者单位：Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech
摘要：Cytokines are critical signaling molecules, but their therapeutic potential remains unrealized due to pleiotropic effects across cell types. Current strategies to develop conditionally active cytokines involve complex engineering and production, limiting their application to a select few cytokines and receptors. Here, we describe a simple, highly modular format called Sterically Masked Activated Cytokine (SMACk) via facile assembly of a targeting Fab/VHH, cytokine, and Fc. We first develop an ...
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作者：Mosconi, Michele; Leonardi, Chiara; -Garb, Zev Armour; Rocutto, Beatrice; Beeg, Marten; Meisl, Georg; Ortigosa-Pascual, Lei; Broggini, Luca; Salmona, Mario; Ricagno, Stefano; Knowles, Tuomas P. J.; Diomede, Luisa
作者单位：University of Cambridge; Lund University; University of Milan; Harvard University; University of London; King's College London
摘要：Interactions between amyloidogenic proteins are emerging as critical drivers of neurodegenerative diseases. Among others, in Alzheimer's disease (AD) and severe forms of chronic traumatic encephalopathy (CTE), codeposition of tau and amyloid-beta (A beta) leads to worsening of clinical outcomes and disease progression. Despite the importance of such heterotypic interactions, the underlying molecular mechanisms have proven challenging to be established. Here, we investigated the direct interact...
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作者：Asiedu, Emmanuel B.; Kumar, Ajay; Choi, Alexander; Luciano, Derek Osorio; Lo, Kevin; Sharma, Deepti; Ma, Tao; Rassool, Feyruz; Sodhi, Akrit; Montaner, Silvia
作者单位：University System of Maryland; University of Maryland Baltimore; Johns Hopkins University; Johns Hopkins Medicine; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore
摘要：Drug chemoresistance remains a major reason of treatment failure in cancer patients. In head and neck squamous cell carcinoma (HNSCC), the seventh most common cancer worldwide, cisplatin chemotherapy remains the gold standard for advanced tumors but often faces loss of responsiveness and the drawback of relapse. We previously showed that the metabolic and angiogenic factor angiopoietin-like 4 (ANGPTL4) is a molecular biomarker of oral dysplasia and HNSCC. We also found that through interaction...
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作者：Bai, Hao; Liu, Xiangzhuo; Yang, Hui; Chave, Jerome; Ciais, Philippe; Wigneron, Jean -Pierre; Saatchi, Sassan; Xiao, Jingfeng; Le Toan, Thuy; Hu, Xiaomei; Yang, Ziyan; Wang, Lijun; Fan, Lei; Yao, Yitong; Chen, Xiuzhi; Liu, Yanxu; Xue, Baolin; Guo, Qinghua; Tang, Zhiyao; Liu, Hongyan; Fang, Jingyun; Tao, Shengli
作者单位：Peking University; Peking University; INRAE; Peking University; Institut de Recherche pour le Developpement (IRD); Universite de Toulouse (EPE); Communaute d'universites et etablissements de Toulouse (Comue); Institut National Polytechnique de Toulouse; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of California System; University of California Los Angeles; University System Of New Hampshire; University of New Hampshire; Centre National d'Etudes Spatiales (CNES); Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse (EPE); Institut de Recherche pour le Developpement (IRD); Communaute d'universites et etablissements de Toulouse (Comue); Southwest University - China; California Institute of Technology; Sun Yat Sen University; Beijing Normal University; Beijing Normal University; Peking University
摘要：Between 2023 and 2024, Amazonian rainforests experienced two consecutive, record-breaking droughts-each more intense than any previously observed-yet their impacts remain largely unquantified. Using newly developed monthly radar satellite observations (1992 to 2025) that track forest moisture and biomass dynamics, we analyzed the long-term responses of intact Amazonian rainforests to past major droughts- particularly the 2023-2024 event-and projected their post-drought recovery. We found a bio...
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作者：Im, Ha Na; Lee, Yeon; Song, Yunju; Hahn, Hyunggu; Jeon, Hyerry; Shin, Donghyuk; Lee, Sangho; Kim, Kyung-Hee; Kim, Kyung-Tae; Suh, Se Won; Jang, Dong Man; Kim, Hyoun Sook
作者单位：National Cancer Center - Korea (NCC); Seoul National University (SNU); Seoul National University (SNU); Yonsei University; Sungkyunkwan University (SKKU); Kookmin University; Harvard University; Harvard Medical School
摘要：The bacterial pathogen Legionella pneumophila secretes effector proteins that remodel host endomembranes to establish a replication-permissive niche known as the Legionella-containing vacuole (LCV). Among these, SetA disrupts vesicle trafficking by glucosylating the small GTPase Rab1, essential for ER-to-Golgi transport. Here, we report comprehensive structural and mechanistic insights into SetA-mediated Rab1 glucosylation and its PI3P-dependent membrane targeting. Crystal structures of its N-...
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作者：Lau, Max S. Y.; Metcalf, C. Jessica E.; Liu, Zewen; Grenfell, Bryan T.; Jin, Wei
作者单位：Emory University; Rollins School Public Health; Princeton University; Emory University
摘要：Foundation models-large AI systems pretrained on broad, heterogeneous data-are transforming scientific discovery. These models (e.g., GPT, GenCast, AlphaFold) excel at learning generalizable representations and adapting to new tasks with limited data. Yet, epidemic modeling has not experienced a comparable transformation. Traditional models remain pathogen-specific and often struggle to generate rapid insights during emerging outbreaks, as starkly illustrated by the SARS-CoV-2 pandemic. This P...
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作者：DePauw, Taylor A.; Gai, Kexin; Shen, Jian; Maurice, Nicholas J.; Rhee, Ka Hyun; Valente, William J.; O'Connor, Christine H.; Cui, Weiguo; Peng, Changwei; Jameson, Stephen C.
作者单位：Harvard University; Harvard Medical School; University of Minnesota System; University of Minnesota Twin Cities; Northwestern University; Feinberg School of Medicine; University of Minnesota System; University of Minnesota Twin Cities
摘要：Numerous transcriptional regulators have been associated with the differentiation pathways that lead to recirculating vs. tissue-resident memory T cells. However, it is unclear whether independent, coordinated expression of these regulators is required to determine residency vs. recirculation or whether there is a hierarchy, with some factors playing a dominant role in controlling T cell trafficking. We report that ablation of the gene encoding Kruppel-like factor 2 (KLF2) during CD8+T cell ac...
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作者：Jozwiak, Adam
作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside
