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作者：Slezak, Tomasz; O'Leary, Kelly M.; Avella, Tanya Guevara; Musial, Natalia; Li, Jinyang; Andrzejczak, Anna; Scott, Elizabeth F.; Le, Duc Anh; Kossiakoff, Anthony A.
作者单位：University of Chicago; Fahrenheit Universities; University of Gdansk; Fahrenheit Universities; Medical University Gdansk; Polish Academy of Sciences; Hirszfeld Institute of Immunology & Experimental Therapy of the Polish Academy of Sciences; University of Chicago
摘要：Inside-Out (I-O) protein display, the noncanonical surface localization of intracellular proteins, represents an underexplored feature of tumor cell biology. Here, we map the molecular landscape and trafficking mechanisms that control the presentation of I-O proteins on cancer cell membranes. Employing APEX2-mediated proximity biotinylation and a custom antibody generation and validation platform, we identified approximately 140 high-confidence I-O proteins, primarily ribosomal, proteasomal, c...
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作者：Cote-Gendreau, Marielle
作者单位：Princeton University
摘要：Migration decisions are embedded in social and family trajectories that escape traditional data sources, which tend to observe individuals in isolation. Genealogical microdata now make it possible to trace these dynamics over long time horizons. This paper documents how prior generations' migration histories shape future internal migration behavior, leveraging rich historical microdata spanning over two centuries and multiple generations at the scale of an entire population (Quebec, Canada; 16...
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作者：Liao, Yawen; Yuan, Luezhen; Sornapudi, Trinadha Rao; Land, Max; Gupta, Rajshikhar; Shivashankar, G., V
作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; ETH Zurich; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：The integration of environmental cues into cellular programs is crucial for cell function. Yet, how this integration is modulated due to cellular aging remains unclear. We propose that the 3D chromatin organization filters these signals and investigated how age-related chromatin changes in human dermal fibroblasts affect responses to mechanical tension and TGF-beta. Young fibroblasts exhibited synergistic gene expression enhancement in response to combined stimuli, a response that was markedly...
