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最新文章

• Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models AI翻译
  作者：Batra, Himanshu; Luo, Sai; Saunders, Kevin O.; Higgins, Jaclyn S.; Jian, Fanchong; Zhang, Jun; Kibria, Md Golam; Jonaid, G. M.; Zhou, Qingchen J.; Eaton, Amanda; Cronin, Kenneth; Mallory, Michael L.; Mattocks, Melissa; Edwards, Robert J.; Parks, Robert; Lee, Esther M.; Ye, Adam Yongxin; Williams, Aimee Chapdelaine; Jung, Geeyoun; Mansouri, Katayoun; Alam, S. Munir; Montefiori, David C.; Tian, Ming; Baric, Ralph S.; Cao, Yunlong; Haynes, Barton F.; Chen, Bing; Alt, Frederick W.
  作者单位：Harvard University; Howard Hughes Medical Institute; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; Duke University; Duke University; Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Peking University; Changping Laboratory; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Duke University; Duke University; Tsinghua University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：During V(D)J recombination, antibody diversity is enhanced by nontemplated junctional modifications that generate immensely diverse heavy chain (HC) and light chain (LC) complementarity-determining 3 antigen-contact regions (CDR3s). We previously developed a mouse model that generates diverse antibody repertoires by rearranging a single human VH1-2 and V kappa 1-33, associated with highly diverse CDR3s generated by V(D)J recombination with mouse Ds and/or Js. Immunization of this model with SA...
• Depth of nutrient uptake by deep- rooted plants is regulated by water availability AI翻译
  作者：Li, Langlang; Christensen, John N.; Bill, Markus; Dong, Wenming; Wu, Yuxin; Beutler, Curtis; Sprenger, Matthias; Gulick, Brian W.; Bone, Sharon E.; Faybishenko, Boris; Sanders, John; Chou, Chunwei; Henderson, Amanda; Bouskill, Nicholas J.; Williams, Kenneth H.; Gilbert, Benjamin
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; North Carolina State University; State University of New York (SUNY) System; Stony Brook University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; University of California System; University of California Berkeley; Oregon State University
  摘要：The capacity of some plants to access water and nutrients at depths greater than one meter is a critical functional trait that confers resistance to drought and impacts both belowground and shallow soil processes. Here, we report water and strontium isotopic data from an alpine meadow transect showing the correlation between water and nutrirock and soil, and in plant leaf tissues, reveal that deeper- rooted plants acquire a higher proportion of water, Sr, and cation nutrients that are derived ...
• Completeness as a fitness landscape for cognitive architectures AI翻译
  作者：Sacco, Pier Luigi
  作者单位：G d'Annunzio University of Chieti-Pescara
• One test, many tongues: Surveying language proficiency across the globe AI翻译
  作者：van Rijn, Pol; Sun, Yue; Lee, Harin; Marjieh, Raja; Sucholutsky, Ilia; Lanzarini, Francesca; Andre, Elisabeth; Jacoby, Nori
  作者单位：Deutsche Bundesbank; Goethe University Frankfurt; Max Planck Society; Princeton University; University of Augsburg; Cornell University
  摘要：Language influences our thinking and affects many aspects of cognition, from how we perceive the world to how we interact socially. Thus, objectively characterizing linguistic background is crucial for research in many areas, including second language acquisition, psycho-linguistics, and cognitive science. Traditional language proficiency tests, however, are manually composed by experts, limiting their scope for both lab and online settings. Here, we propose a pipeline that automatically deriv...
• VIBES: A multiscale modeling approach integrating within-host and between-hosts dynamics in epidemics AI翻译
  作者：Ventura, Paulo Cesar; Jeong, Yong Dam; Litvinova, Maria; Kummer, Allisandra G.; Iwami, Shingo; Yu, Hongjie; Merler, Stefano; Vespignani, Alessandro; Ejima, Keisuke; Ajelli, Marco
  作者单位：Indiana University System; Indiana University Bloomington; Nagoya University; Pusan National University; Pukyong National University; Indiana University System; Indiana University Bloomington; Fudan University; Fudan University; Fudan University; Fondazione Bruno Kessler; Northeastern University; Nanyang Technological University
  摘要：Infectious disease spread is a multiscale process composed of within-host (biological) and between-host (social) drivers and disentangling them from each other is central challenge in epidemiology. Here, we introduce VIBES, a multiscale modeling framework that explicitly integrates viral dynamics based on patient-level data with population-level transmission on a data-driven network of social contacts. Using SARS-CoV-2 as a case study, we analyze three emergent epidemic properties, namely the ...
• Receptor sequence divergence, gain, loss, duplication, and neofunctionalization drive olfactory adaptation in Drosophila suzukii AI翻译
  作者：Xue, Qi; Dweck, Hany K. M.
  作者单位：Connecticut Agricultural Experiment Station
  摘要：Shifts in ecological niches are often driven by evolutionary changes in the olfactory system, yet the underlying mechanisms remain poorly understood. To investigate this, we used Drosophila suzukii, an invasive fruit pest, as a model. Unlike most Drosophila species, which prefer overripe fruit, D. suzukii strongly prefers laying eggs in ripe fruit. We found that this shift is accompanied by pronounced changes in the odorant tuning of only a few olfactory receptor neurons (ORNs) compared to Dro...
• Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels (vol 118 , e2023868118 , 2021 ) AI翻译
  作者：Goyette, Marie-Anne; Elkholi, Islam E.; Apcher, Chloe; Kuasne, Hellen; V. Rothlin, Carla; Muller, William J.; Richard, Darren E.; Park, Morag; Gratton, Jean-Philippe; Cote, Jean-Francois
• The psychology of offensive and defensive intergroup violence: Preregistered insights from 58 countries AI翻译
  作者：Kunst, Jonas R.; Besta, Tomasz; Jaskiewicz, Michal; Gajda, Anna Natalia; Sanden, Markus; Flatebo, Mina Marie; Adebayo, Sulaiman Olanrewaju; Adonis, Marios; Agyemang, Collins Badu; Boateng, Raymond Agyenim; Akfirat, Serap Arslan; Al-adawi, Samir; Ambrosio, Chiara; Anjum, Gulnaz; Aruta, John Jamir Benzon R.; Austers, Ivars; Barry, Oumar; Bastian, Brock; Becker, Maja; Bender, Michael; Benningstad, Nora Cornelia Glerud; Borinca, Islam; Celikkol, Goksu; Cenek, Jiri; Chaleeraktrakoon, Trawin; Chobthamkit, Phatthanakit; Choi, Hoon-Seok; Choi, Suyeong; Ciordas, Patricia; Coenen, Ann-Cathrin; Cupta, Aleksandra; de Zoysa, Piyanjali; Dhakal, Sandesh; Duncan, Lauren E.; Elcil, Tugcenaz; Eskiili, Barkan; Etchezahar, Edgardo; Franc, Renata; Galdi, Silvia; Garvanova, Magdalena; Gill, Paul; Gnisci, Augusto; Gomez, Angel; Yepes, Talia Gomez; Grossmann, Igor; Haines, Emily A.; Haka, Fatjona; Hameiri, Boaz; Hamzah, Imaduddin; Helmy, Mai; Imhoff, Roland; Kamble, Shanmukh; Kazarovytska, Fiona; Kende, Anna; Khachatryan, Narine; Kimel, Sasha Y.; Klein, Jack W.; Komisarof, Adam; Lacko, David; Lajunen, Timo Juhani; Lasticova, Barbara; Lopez-Calle, Claudio; Lopez-Lopez, Wilson; Maglica, Barbara Kalebic; Malinauskas, Romualdas; Manusyan, Sona; Martskvishvili, Khatuna; Messanga, Gustave Adolphe; Miklikowska, Marta; Minic, Jelena; Mohoric, Tamara; Mottola, Francesca; Mula, Silvana; Musso, Pasquale; Ndiaye, Dieynaba Gabrielle; Neto, Felix; Neto, Joana; Dieng, Laina Ngom; Obioma, Ihuoma Faith; Olonisakin, Tosin Tunrayo; Ozer, Simon; Panagiotopoulou, Penny; Pastwa-Wojciechowska, Beata; Pavlopoulos, Vassilis; Pavlovic, Tomislav; Petrovska, Inha; Piotrowski, Andrzej; Poslon, Xenia Daniela; Pummerer, Lotte; Raina, Mahima; Ramos-Diaz, Jano; Robertsson, Vilja; Rottweiler, Bettina; Sam, David L.; Scardigno, Rosa; Schulmeyer, Marion K.; Stefaniak, Anna; Studzinska, Anna; Sullman, Mark J. M.; Szulc, Marcin; Nemboue, Willy Taffo; Tair, Ergyul; Tausch, Nicole; Thagunna, Narendra Singh; Thomas, Emma F.; Ungaretti, Joaquin; Van Laar, Colette; Vazne, Zermena; Vazquez, Alexandra; Villanueva-Alvarado, Jose; Wlodarczyk, Anna; Yogeeswaran, Kumar; Obaidi, Milan
  作者单位：BI Norwegian Business School; Fahrenheit Universities; University of Gdansk; University of Oslo; University of Nicosia; University of Ghana; Hong Kong Polytechnic University; Dokuz Eylul University; Sultan Qaboos University; Universita della Campania Vanvitelli; University of Limerick; De La Salle University; University of Latvia; University Cheikh Anta Diop Dakar; University of Melbourne; Centre National de la Recherche Scientifique (CNRS); Communaute d'universites et etablissements de Toulouse (Comue); Tilburg University; University of Groningen; Mendel University in Brno; Thammasat University; Sungkyunkwan University (SKKU); University of Waterloo; Eotvos Lorand University; University of Colombo; Tribhuvan University; Smith College; Gedik University; Autonomous University of Madrid; Ivo Pilar Institute of Social Sciences; University for Library Studies & Information Technology; University of London; University College London; Universidad Nacional de Educacion a Distancia (UNED); University of Johannesburg; Flinders University; University of Tirana (UT); Tel Aviv University; Sultan Qaboos University; Johannes Gutenberg University of Mainz; Karnatak University; Yerevan State University; California State University System; California State University San Marcos; Chinese University of Hong Kong; Keio University; Czech Academy of Sciences; Institute of Psychology of the Czech Academy of Sciences; Norwegian University of Science & Technology (NTNU); University of Helsinki; Slovak Academy of Sciences; Institute for Research in Social Communication, SAS; Universidad de Cuenca; Pontificia Universidad Javeriana; University of Rijeka; Lithuanian Sports University; Universite de Dschang; Linnaeus University; Universiteti i Prishtines; University of Cagliari; Universita degli Studi di Bari Aldo Moro; Universidade do Porto; Universidade Portucalense Infante D. Henrique; Goethe University Frankfurt; Hochschule Angewandte Wissenschaft Hamburg; Aarhus University; University of Patras; National & Kapodistrian University of Athens; Ministry of Education & Science of Ukraine; Ivan Franko National University Lviv; University of Bremen; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kharagpur; Universidad Privada del Norte; University of Gothenburg; University of Nebraska System; University of Bergen; University of St Andrews; Bulgarian Academy of Sciences; KU Leuven; Riga Stradins University; Pontificia Universidad Catolica del Peru; Universidad Catolica del Norte; University of Canterbury; University of Copenhagen
  摘要：Evolutionary theory and historical evidence suggest humans possess distinct psychological tendencies for defensive and offensive violence, which have insufficiently been considered in research. In a large-scale preregistered study across 58 countries (N = 18,128), we demonstrate that violent extremist intentions manifest along two distinct psychological phenomena: defensive extremism, motivated by protecting one's group from (perceived) threats, and offensive extremism, driven by establishing ...
• Biologically grounded on-chip model identifies selective topographic reorganization within hyperexcitable corticostriatal networks AI翻译
  作者：Poinsot, Maxime; Dos Santos, Marine; Marthy, Baptiste; Borges-Correia, Ana; Gascon, Eduardo; Charlot, Benoit; Cazorla, Maxime
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS)
  摘要：The mammalian cerebral cortex projects to the striatum in a precise, hierarchical topography, forming parallel loops that underlie sensorimotor, associative, and limbic processing. Despite the striatum's lack of clear anatomical boundaries, these projections remain functionally segregated, suggesting the existence of intrinsic organizing principles. Disruptions in corticostriatal connectivity and excitability are common in neurodevelopmental disorders, but it remains unclear whether such abnor...
• Immune cell profiling reveals expanded stem cell-like memory T cells in anti-GAD65-associated neurological syndromes AI翻译
  作者：Barman, Sumanta; Rauber, Saskia; Eisenhut, Katharina; Esser, Daniela; van Duijn, Martijn; Scharf, Madeleine; Herrera-Rivero, Marisol; Disse, Paul; Preuth, Lara-Maria; Gulyaeva, Valeria; Schwan, Ilja; vom Stein, Eliza; Jonas, Marius; Pul, Duygu; Heming, Michael; Muller-Miny, Louisa; Paunovic, Manuela; Strippel, Christine; Haholu, Ebru; Bartosch, Jan; Kaufmann, Elisabeth; Dargvainiene, Justina; Kahl, Sabine; Ringelstein, Marius; Bindels, Eric; Wiendl, Heinz; Stoecklein, Nikolas H.; Fischer, Johannes; Goebels, Norbert; Komorowski, Lars; Roden, Michael; Rossi, Andrea; Stoll, Monika; Becker, Albert J.; Hamed, Motaz; Bien, Christian G.; Hoftberger, Romana; Bauer, Jan; Meuth, Sven G.; Titulaer, Maarten J.; Leypoldt, Frank; zu Horste, Gerd Meyer; Thaler, Franziska; Melzer, Nico
  作者单位：Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; University of Munich; University of Munich; University of Kiel; Schleswig Holstein University Hospital; Erasmus University Rotterdam; Erasmus MC; University of Munster; University of Munster; University of Munich; University of Munich; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Leibniz Association; Heinrich Heine University Dusseldorf; Deutsches Diabetes-Zentrum (DDZ); German Center for Diabetes Research (DZD); Heinrich Heine University Dusseldorf; Erasmus University Rotterdam; Erasmus MC; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Leibniz Association; Leibniz Institut fur Umweltmedizinische Forschung (IUF); University of Bonn; University of Munster; University of Bonn; University of Bielefeld; Medical University of Vienna; Medical University of Vienna; Medical University of Vienna; University of Kiel; Schleswig Holstein University Hospital
  摘要：The immunopathogenesis of autoimmune neurological syndromes (AINS) with antibodies against the 65 kDa isoform of glutamic acid decarboxylase (anti-GAD65 AINS) remains poorly understood. To elucidate underlying disease mechanisms and identify relevant cell populations, we performed single-cell RNA and immune repertoire sequencing of cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMCs) of eight anti-GAD65 AINS individuals compared to eight noninflammatory controls. In additio...