13期

最新文章

• Rethinking same-sex sexual behavior: From sensory error to social function AI翻译
  作者：Torsekar, Viraj R.
  作者单位：Gandhi Institute of Technology & Management (GITAM)
• Oseltamivir aziridines are potent influenza neuraminidase inhibitors and imaging agents AI翻译
  作者：Vriends, Merijn B. L.; Moran, Elisha; Calvelo, Martin; Hansen, Thomas; Pickles, Isabelle B.; Xin, Xincheng; Biezeno, Marieke; Armstrong, Zachary W. B.; Ferraz, Maria J.; Li, Lei; Lilley, Alice; Harvey, Ruth; Filippov, Dmitri, V; Liao, Qinghua; van der Marel, Gijsbert A.; Artola, Marta; Aerts, Johannes M. F. G.; Blaza, James N.; Codee, Jeroen D. C.; Rovira, Carme; Overkleeft, Herman S.; Davies, Gideon J.
  作者单位：Leiden University; Leiden University - Excl LUMC; University of York - UK; University of Barcelona; University of Barcelona; Leiden University; Leiden University - Excl LUMC; Francis Crick Institute
  摘要：Influenza neuraminidase (NA) is a critical target for seasonal and pandemic antivirals, including the strains of current concern. Current treatments, such as Zanamivir and Oseltamivir, are limited by noncovalent binding and emerging resistance. We hypothesized that Oseltamivir aziridines would unite transition-state mimicry for tight binding, with aziridine-enabled covalent capture of the catalytic tyrosine, thereby supporting both therapy and activity-based quantification. Here, we present os...
• Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs AI翻译
  作者：Devakinandan, G. V. S.; Rishad, Abdul; Nanda, Nandana; Hussain, Syed Dastagir; Subedi, Sishir; Dani, Adish
  作者单位：Tata Institute of Fundamental Research (TIFR); University of British Columbia
  摘要：Mouse vomeronasal sensory neurons are continuously generated from stem cells and differentiate to express either V1R or V2R G protein-coupled receptors (GPCRs), along with their respective G alpha i2 or G alpha o G-protein subunits. We previously reported that G alpha o-type neurons exhibit elevated expression of endoplasmic reticulum (ER) chaperones and a distinctive hypertrophic, gyroid ER architecture, suggesting specialized proteostatic demands. Here, we identify a transcript for the mouse...
• Life-like behavior emerging in active and flexible microstructures AI翻译
  作者：Wei, Mengshi; Kraft, Daniela J.
  作者单位：Leiden University; Leiden University - Excl LUMC
  摘要：Many organisms leverage an interplay between shape and activity to generate motion and adapt to their environment. Embedding such mechanical feedback into synthetic micrometer-sized robots could eliminate the need for sensors, software, and actuators. Current active micrometer-scale systems, however, do not possess a flexible body with which they can autonomously sense and react to their environment. Here, we experimentally realize active and flexible structures by concatenating anisotropic mi...
• Inhibition of coronaviral exoribonuclease activity by TRIM- mediated SUMOylation AI翻译
  作者：Balakrishnan, Kannan; Chakraborty, Surajit; Chiang, Cindy; Stratton, Caleb M.; Pandey, Shanti; Tumanova, Anna A.; Olsen, Shaun K.; Gack, Michaela U.
  作者单位：Cleveland Clinic Foundation; University of Texas System; University of Texas at San Antonio
  摘要：Members of the TRIM E3 ligase family are effectors of the host innate or intrinsic virus infection is still largely elusive. Through an RNAi screen targeting 71 human TRIM genes, we identified multiple TRIM proteins with antiviral or proviral activity against and its antiviral activity are broadly conserved for coronaviruses. These results identify which may uncover ways to therapeutically inhibit coronavirus infections in humans.
• The archaeal roots of eukaryotic life AI翻译
  作者：De Anda, Valerie; Appler, Kathryn E.; Pine, Emily Aguilar -; Aitolo, Georgina L.; Halverson, Galen P.; Baker, Brett J.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; McGill University; University of Vienna
  摘要：Resolving the biological and geological events that led to the origin of eukaryotes is an ongoing challenge in biology. A major step in the evolution of complex cellular life was the merger between an ancestral host cell and a bacterium (that became the mitochondrion) some two billion years ago. Recently, metagenomics has enabled the reconstruction of a broad diversity of genomes, referred to as the Asgard Archaea. The Asgards are monophyletic with eukaryotes on the tree of life. Asgards have ...
• How to revive science in America AI翻译
  作者：Fineberg, Harvey V.
  作者单位：Harvard University
• The power of leadership in changing social norms in heterogeneous societies AI翻译
  作者：Galeotti, Fabio; Krutaj, Jona; Villeval, Marie Claire
  作者单位：Universite Lyon 2; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Jean Monnet; Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); emlyon business school; University of Nottingham
  摘要：Abandoning detrimental social norms is complex due to the strong pressure to conform. We examine how leaders can guide norm change in heterogeneous societies where individual preferences evolve at different rates. Inspired by the model and experimental design of [J. Andreoni, N. Nikiforakis, and S. Siegenthaler, Proc. Natl. Acad. Sci. U.S.A. 118, e2014893118 (2021)], we conduct a large-scale laboratory experiment in which we manipulate the speed at which preferences change within a society and...
• Specialization of independently acquired flagellar FliC proteins in plant- associated Sphingomonas balances swimming and immunogenicity AI翻译
  作者：Russ, Dor; Saha, Chinmay; Paul, Karnelia; Zheng, Zhiyu; Law, Theresa F.; Anguita-Maeso, Manuel; Lundberg, Derek S.; Fitzpatrick, Connor R.; Dangl, Jeffery L.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Howard Hughes Medical Institute; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Swedish University of Agricultural Sciences; Tel Aviv University; Johns Hopkins University; University of Calgary
  摘要：Plants monitor their environment for microbial invaders using pattern- recognition receptors that detect microbe- associated molecular patterns (MAMPs). Flagellin, the main component of bacterial flagellum, contains the flg22 epitope recognized by the plant immune receptor FLS2. Immune recognition can create an evolutionary conflict, requiring bacteria to balance flagellar function and immune evasion. Here, we show that plant- associated Sphingomonas resolve this constraint by partitioning two...
• Convergent evolution increases boron transport through SNPs and tandem duplications at BOR1 and BOR2 in Arabidopsis thaliana AI翻译
  作者：Tergemina, Emmanuel; Neto, Celia; Rashid, Md Mamunur; Dinis, Herculano; Salt, David E.; Hancock, Angela M.
  作者单位：Max Planck Society; University of Nottingham; Purdue University System; Purdue University; University of Copenhagen
  摘要：Boron (B) is a crucial micronutrient, particularly in volcanic soils where its deficiency hampers agriculture. Here, we investigate the genetic basis of leaf B accumulation in natural populations of Arabidopsis thaliana that colonized volcanic islands in Cape Verde. Using a combination of genome- wide association studies (GWAS) and mapping in a recombinant intercross population, we identified a case of convergent phenotypic evolution in which multiple variants in the two principal B transporte...