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作者：Sangchai, Pun; Sarnow, Peter; Somboonwiwat, Kunlaya
作者单位：Chulalongkorn University; Stanford Medicine; Stanford University
摘要：Small RNAs and microRNAs (miRNAs) play diverse roles in host virus interactions and hold promise for therapeutic applications. An uncharacterized shrimp miRNA with potent activity against white spot syndrome virus (WSSV), a major double-stranded DNA pathogen in aquaculture, was identified and characterized. Among the 1,239 differentially expressed unannotated small RNAs in Penaeus vannamei hemocytes, one of the most strongly downregulated candidates, termed pva-small RNA-11881 or pva-miR-11881...
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作者：Suetsugu, Kenji; Johnson, Steven D.
作者单位：Kobe University; Kobe University; University of Kwazulu Natal
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作者：Barmada, Mohamed I.; McGinity, Erin N.; Nandi, Suparno; Dey, Debayan; Zelinskaya, Natalia; Harris, George M.; Comstock, Lindsay R.; Dunham, Christine M.; Conn, Graeme L.
作者单位：Emory University; Emory University; Wake Forest University; Emory University
摘要：Ribosomal RNA (rRNA) modifications are important for ribosome function and can influence bacterial susceptibility to ribosome-targeting antibiotics. The universally conserved 16S rRNA nucleotide C1402, for example, is the only 2'-O-methylated nucleotide in the bacterial small (30S) ribosomal subunit and this modification fine-tunes the shape and structure of the peptidyl tRNA binding site. The Cm1402 modification is incorporated by the conserved bacterial 16S rRNA methyltransferase RsmI, but i...
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作者：Kadam, Rameshwar U.; Juraszek, Jarek; Brandenburg, Boerries; Garg, Divita; Zhu, Xueyong; Jongeneelen, Mandy; Tang, Chan; Schepens, Wim B. G.; Buyck, Christophe; Stoops, Bart; Vermond, Jan; Vogels, Ronald; Friesen, Robert H. E.; van Dongen, Maria J. P.; Wilson, Ian A.
作者单位：Scripps Research Institute; Scripps Research Institute
摘要：Influenza continues to be a major threat to global health and a substantial economic burden. Innovative strategies are needed to tackle the growing resistance to established influenza therapeutics and to develop new therapeutics with novel mechanisms of action. Previous peptide and small molecule designs have been successful only against influenza group 1 hemagglutinin (HA). Here, we report on a CLIPS (Chemical Linkage of Peptides onto Scaffolds)-based approach to design potent peptidic inhibi...
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作者：Magarditchian, Garine; Berest, Ivan; Ziogou, Aikaterini; Matsushita, Mai; Reid, Michelle; Othman, Alaa; Kopf, Manfred
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Iron-dependent phospholipid (PL) peroxidation, which is reduced by glutathione peroxidase 4, is recognized as the hallmark of cells undergoing ferroptosis. Although studies have attempted to elucidate the molecular mechanisms underlying ferroptosis in cancer cells, the regulation of ferroptosis in effector and memory T cells remains largely unknown. Here, using genome-wide CRISPR-Cas9 knockout screens, we demonstrate that acyl-CoA synthetase long-chain family member 4 (ACSL4) is the predominan...
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作者：Simon, Ignasi; van den Elshout, Rebecca F. A.; Wardhana, Gandhika K.; Aqamolaei, Masoumeh; de Jonge, Isabella S. T.; Hartkamp, Remco; Alessandri, Riccardo; Costa, Tiago L.; Rwei, Alina Y.
作者单位：Delft University of Technology; Delft University of Technology; Delft University of Technology; KU Leuven
摘要：Ultrasound offers a noninvasive, clinically relevant means to achieve precise spatiotemporal control of cargo release from ultrasound-responsive drug delivery systems within deep tissues. This approach enables targeted delivery of therapeutic agents, enhancing efficacy while minimizing systemic toxicity. While previous studies show that release from ultrasound-responsive liposomes depends on acoustic parameters, the underlying mechanisms remain unclear. A deeper mechanistic understanding is es...
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作者：Allesina, Stefano
作者单位：University of Chicago; Northwestern University
摘要：The replicator and the Generalized Lotka-Volterra equations are closely related, foundational models in evolutionary game theory and community ecology, respectively. The concept of evolutionary stability and its relationship with dynamic stability has received significant attention: In the replicator equation, an evolutionarily stable strategy is also dynamically globally stable-i.e., will be reached by any trajectory originating from positive conditions. Intriguingly, the converse is not true...
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作者：Gwynn, Justin P.; Heldal, Hilde Elise; Teien, Hans-Christian; Volynkin, Andrey; Jerome, Simon M.; Lind, Ole Christian
作者单位：Institute of Marine Research - Norway; Norwegian University of Life Sciences; Institute of Marine Research - Norway
摘要：The study documents in detail the extent of damage to the exterior of the sunken nuclear submarine Komsomolets and that previous remedial action carried out by Russia was still in place. No evidence was found of any plutonium in the near environment around the damaged forward section of the submarine from the nuclear warheads that were reported to be part of Komsomolets armament in the torpedo compartment. It was confirmed that releases from the reactor were still occurring, but not continuous...
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作者：Nguyen, Ngan N. M.; Brady, Alexander E.; Russi, Abigail; Pham, Giang; Li, Bo; Turner, Lucien H.; Kotliar, Michael; Barski, Artem; Sun, Xiaofei; Way, Sing Sing
作者单位：University System of Ohio; Cincinnati Children's Hospital Medical Center; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Indiana University Health; Indiana University System; James Whitcomb Riley Hospital Children; Indiana University Bloomington
摘要：Pregnancy requires expanded maternal tolerance to semiallogeneic fetal- expressed antigens to protect against fetal loss and other pregnancy complications. Our understanding of how this biological imperative works remains uncertain. Here we show pregnancy primes expansion of antigen- experienced Kr & uuml;ppel- like factor 2 (KLF2)+ CD4 T cells with fetal specificity, and that these maternal cells play an essential role in optimal fertility and protecting against fetal resorption. Antigen- exp...
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作者：Obaid, Abdulmalik; Hanna, Mina-Elraheb; Huang, Song-Wen; Hu, Yu-Ting; Jaidar, Omar; Nix, William; Ding, Jun B.; Melosh, Nicholas A.; Wu, Yu-Wei
作者单位：Stanford University; Academia Sinica - Taiwan; National Taiwan University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Academia Sinica - Taiwan; Academia Sinica - Taiwan; National Taiwan University; National Defense University - Taiwan; Academia Sinica - Taiwan
摘要：Microscale electrodes, on the order of 10 to 100 & micro;m, are rapidly becoming critical tools for neuroscience and brain-machine interfaces for their high channel counts and spatial resolution, yet the mechanical details of how probes at this scale insert into brain tissue are largely unknown. Here, we performed quantitative measurements of the force and compression mechanics together with real-time microscopy for in vivo insertion of a systematic series of microelectrode probes as a functio...
