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作者：de la Cotte, Alexis; Tang, Xingzhou; Chen, Chuqiao; Kole, S. J.; Atzin, Noe; de Pablo, Juan J.; Abbott, Nicholas L.
作者单位：Cornell University; University of Chicago; Nanjing University of Posts & Telecommunications; Nanjing University of Posts & Telecommunications; University of Cambridge; New York University; New York University Tandon School of Engineering; New York University; New York University; United States Department of Energy (DOE); Argonne National Laboratory
摘要：Predicting and controlling the propagation of nonlinear responses in materials is critical to a range of fields, from the manipulation of single electrons in quantum optics to the understanding of crack propagation and failure of quasi- brittle materials. Solitons, which are highly localized strain patterns that propagate and persist due to nonlinear feedback mechanisms, can be produced in liquid crystal (LC) films under high- frequency AC electric fields. In previous work using uniformly orie...
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作者：Maier, Bert; Pilz, Luisa K.; Ozcakir, Selin; Rahjouei, Ali; Abdo, Ashraf N.; de Zeeuw, Jan; Kunz, Dieter; Kramer, Achim
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Cornell University; Weill Cornell Medicine
摘要：Circadian clocks govern daily physiological and behavioral processes and are crucial for health; disruptions can lead to various diseases. The circadian phase of entrainment-the phase of the internal circadian clock in relation to external environmental cycles-is influenced by both genetic and environmental factors, varies between individuals, and is reflected in daily behaviors such as sleep-wake patterns, cognitive performance, and physical activity.While circadian phase may also fluctuate w...
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作者：Szukalo, Ryan J.; Neophytou, Andreas; Gomez, Axel; Giovambattista, Nicolas; Sciortino, Francesco; Debenedetti, Pablo G.
作者单位：Princeton University; Sapienza University Rome; City University of New York (CUNY) System; Brooklyn College (CUNY); City University of New York (CUNY) System; City University of New York (CUNY) System; Princeton University
摘要：Water's anomalous thermodynamic behavior arises from the presence of intricate hydrogen-bond networks that are highly sensitive to many-body interactions, challenging molecular modeling for decades. The ongoing machine learning revolution has opened the possibility of performing quantum-accurate liquid-structure calculations at affordable computational cost. Beyond reproducing water's thermodynamic properties with high fidelity, such simulations provide a stringent benchmark for theoretical mo...
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作者：Thompson, Jaron; Connors, Bryce M.; Zavala, Victor M.; Venturelli, Ophelia S.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Duke University; Duke University
摘要：Microbial communities play essential roles in shaping ecosystem functions and predictive modeling frameworks are crucial for understanding, controlling, and harnessing their properties. Competition and cross-feeding of metabolites drives microbiome dynamics and functions. Existing mechanistic models that capture metabolite-mediated interactions in microbial communities have limited flexibility due to rigid assumptions. While machine learning models provide flexibility, they require large datas...
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作者：van Noordwijk, Meine; Nziguheba, Generose; Tomich, Thomas P.; Scholes, Mary; Agus, Fahmuddin; Winowiecki, Leigh; Kasyoki, Joyce; Minang, Peter A.
作者单位：Flanders Institute for Biotechnology (VIB); University of California System; University of California Davis; University of Witwatersrand; National Research & Innovation Agency of Indonesia (BRIN)
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作者：Watanabe, Noriya; Yoshida, Shinichi; Keerativittayayut, Ruedeerat; Takeda, Masaki
作者单位：Kochi University Technology; Kochi University Technology; Chulabhorn Royal Academy
摘要：Neurophysiological mechanisms underlying psychological resilience-the ability to overcome adversity-have been extensively studied in animals. However, compared to that in animals, human resilience is unique in that it is underpinned by higher-order cognitive functions, such as self-confidence, tenacity, and a positive attitude to challenges. Given these discrepancies, the neurophysiological mechanisms underlying human-specific resilience remain unclear. To address this issue, we aimed to recor...
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作者：Shen, Luo-Qin; Wang, Lu; Yao, Zhiyuan; Lin, Da; Ye, Yu-Qiu; Zhang, Wan-rong; Ye, Mao; Sun, Ming-Ming; Du, Shuai; Wu, Di; O'Connor, Patrick; Zhu, Dong
作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Ningbo University; Ocean University of China; Kunming University of Science & Technology; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Nanjing Agricultural University; Queens University Belfast; Adelaide University; University of Adelaide
摘要：Heavy metals are increasingly recognized as major drivers of antibiotic resistance gene (ARG) dissemination in soil ecosystems. However, the role of phages in heavy metal- driven ARG dissemination and the underlying mechanisms remain poorly understood. Here, through integrative metagenomic, viromics, and metabolomic analyses of paddy soils across China, we reveal that soil phages promote ARG dissemination under heavy metal stress, likely through two potential mechanisms. First, phage- encoded ...
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作者：Wolosker, Herman; Liebl, Daniel J.
作者单位：Technion Israel Institute of Technology; Rappaport Faculty of Medicine; University of Miami
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作者：Gorrini, Chiara; Jafari, Soode; Duncan, Gordon; Snow, Bryan; Hendrikse, Liam; McLoughlin, Louis; Haight, Jillian; Wakeham, Andrew; Tobin, Chantal; Elia, Andrew; Ramachandran, Paramesh; Law, Rhoda; Gang, Bevan; Lu, Tsai-Ling; Morgado-Palacin, Isabel; You-Ten, Annick; Berger, Thorsten; Sordella, Raffaella; Mak, Tak W.
作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Leeds; Cold Spring Harbor Laboratory; University of Hong Kong; University of Toronto; University of Toronto
摘要：Through alternative splicing, the TP53 gene can generate multiple protein isoforms with distinct biochemical properties. The p53psi isoform has been identified as a shorter variant than full-length p53 as it lacks nuclear localization, oligomerization, and part of the DNA binding domains due to the use of an alternative 3' splice site in intron 6. Several TP53-truncating mutations, including those producing p53psi, have been detected in a significant proportion of human tumors. However, the me...
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作者：LaPorte, Philip; Hilbe, Christian; Glynatsi, Nikoleta E.; Nowak, Martin A.
作者单位：University of California System; University of California Berkeley; Harvard University; RIKEN
