-
作者：Yang, Chen; Yang, Yang; Liu, Zheng; Bai, Xinpeng; Ma, Xiaohui; Tang, Jihong; Huang, Rui; Liao, Yuanyuan; Liu, Yang; Wen, Lu; Liu, Min; Zhu, Alan Jian; Yu, Cong; Guo, Yusong; Wang, Jiguang; Li, Xiang David; Ishibashi, Toyotaka; Yan, Yan
作者单位：Hong Kong University of Science & Technology; University of Hong Kong; Huazhong University of Science & Technology; Peking University; Southern University of Science & Technology; Southern University of Science & Technology; Hong Kong University of Science & Technology; Chinese Academy of Sciences; Hong Kong University of Science & Technology; Shenzhen Institute of Advanced Technology, CAS; Hong Kong University of Science & Technology
摘要：The host metabolic state can potentially affect the growth trajectories of tumors growing at local sites, which are highly variable and unpredictable among populations. The molecular links between systemic metabolism and tumor growth outcomes remain largely unclear. Here, we harnessed the genetic power of the Drosophila model to perform genetic screens and identified molecular players in the adipose tissue that can change the growth trajectory of remotely growing tumors. We found that variatio...
-
作者：Gotz, Miriam S.; Hayman, Dan J.; Adams, Gracie; Obata, Fumiaki; Simons, Mirre J. P.
作者单位：University of Sheffield; RIKEN; Kyoto University
摘要：Stress response pathways are emerging as conserved modulators of lifespan. The prevailing hypothesis is that activation of stress-responsive pathways, including the amino acid deprivation arm of the integrated stress response (ISR; the GCN2-ATF4 pathway), is prolongevity. Activation of ATF4 orthologs extends lifespan in Saccharomyces cerevisiae and Caenorhabditis elegans , but its role in other longer-lived organisms remains unclear. We comprehensively tested the role of the GCN2-ATF4 pathway ...
-
作者：Jung, Mark; Wen, Zhengyu; Humbert, Sabrina; Lu, Fengzhong; DeLeon, Alyssa; Marshall, Lisa; Hastings, Craig; Cartwright, Heather; Thilges, Katherine; Wang, Ning; Breckenridge, Kassandra; Wu, Emily; Ryan, Larisa; Fengler, Kevin; Simcox, Kevin; Thatcher, Shawn; Llaca, Victor; Woollums, Grace; Sander, Jeffry; Xu, Deping; Beatty, Mary; Brink, Kent; Fedorova, Maria; Jones, Mark; Ohlson, Erik; Suresh, L. M.; Beyene, Yoseph; Olsen, Michael; Ogugo, Veronica; Alakonya, Amos; Murithi, Ann; Mugo, Stephen; Karanja, James; Boddupalli, Prasanna; Pixley, Kevin; Albertsen, Marc; Jones, Todd; Meeley, Robert; Gutterson, Neal; Mazur, Barbara; Dhugga, Kanwarpal S.
作者单位：CGIAR; International Maize & Wheat Improvement Center (CIMMYT); United States Department of Agriculture (USDA); Australian National University; Sichuan Agricultural University; Bayer AG; Punjab Agricultural University
摘要：Maize lethal necrosis (MLN) is a severe disease caused by the combined infection of maize chlorotic mottle virus (MCMV) and a potyvirus, most often sugarcane mosaic virus (SCMV). This disease seriously threatens food security across sub-Saharan Africa (SSA). We investigated a major-effect quantitative trait locus for resistance on chromosome 6, named the maize lethal necrosis susceptibility locus 1 (qMLNS1), derived from the Thai line KS23-6. Fine mapping and CRISPR-Cas9 editing of the candida...
-
作者：Mao, Chenkai; Fan, Jonathan A.
作者单位：Stanford University
摘要：Neural networks have promise as surrogate partial differential equation (PDE) solvers, but it remains a challenge to use these concepts to solve problems with high accuracy and scalability. In this work, we show that neural network surrogates can combine with iterative algorithms to accurately solve PDE problems featuring different scales, resolutions, and boundary conditions. We develop a subdomain neural operator model that supports arbitrary Robin-type boundary condition inputs, and we show...
-
作者：Zhu, Ruiqi; Hu, Zhengwei; Lou, Zirui; Xie, Fei; Zhao, Shuainan; Jiao, Xuechen; Wang, Jianyu; Fukuda, Kenjiro; Chen, Xiaodong; Hu, Wenping; Cheng, Hui-Ming; Li, Xiaojian; Someya, Takao; Xu, Xiaomin
作者单位：Tsinghua University; Tsinghua Shenzhen International Graduate School; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; RIKEN; RIKEN; Nanyang Technological University; Nanyang Technological University; Tianjin University; Tianjin University; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Metal Research, CAS; University of Tokyo
摘要：Chronic neural interfaces are essential for advancing brain-computer interfaces, neuroprosthetics, and neuromodulation technologies. However, a long-standing trade-off between performance and longevity persists due to the scarcity of materials that simultaneously achieve superior electrical performance, mechanical compliance, and biocompatibility. Here, we overcome this limitation with an all-organic, ultraflexible electrocorticography (ECoG) design that features a thickness of only 9 & micro;...
-
作者：An, Seong J.; Suzuki, Yoshihisa; Mohanty, Jyotidarsini; Tome, Francisco; Lax, Irit; Schlessinger, Joseph
作者单位：Yale University
摘要：An important mechanism by which receptor tyrosine kinases (RTKs) mediate cellular responses involves the formation of signaling complexes through direct interactions with membrane-associated docking proteins, followed by phosphorylation of multiple tyrosine residues. These docking proteins recruit and activate downstream signaling molecules and enzymes following ligand stimulation. The docking protein FRS2 alpha has been established as a major signaling hub activated by fibroblast growth facto...
-
作者：Fujita, Yasuhiko; Takahashi, Mariko; Taemaitree, Farsai; Uji-i, Hiroshi; Watanabe, Hirohmi
作者单位：National Institute of Advanced Industrial Science & Technology (AIST); Hokkaido University; Hokkaido University; KU Leuven; Kyoto University
摘要：Atomic force microscopy-based infrared (AFM-IR) microscopy has emerged as a powerful tool for nanoscale chemical imaging, combining the topographical precision of AFM with the molecular specificity of IR spectroscopy. However, its performance is still limited by conventional metal-coated AFM probes, which provide only modest near-field enhancement, ultimately restricting both spatial resolution and chemical sensitivity. In this work, we present a nanowire-based AFM-IR approach that overcomes t...
-
作者：Huang, Dong'e; Dong, Junqing
-
作者：Muskat, Natali H.; Nevo-Yassaf, Inbar; Chaurasia, Madhuri; Reiss, Shani; Goliand, Inna; Kupervaser, Meital; Addadi, Yoseph; Levin, Yishai; Fraiberg, Milana; Elazar, Zvulun
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
摘要：Biological membranes provide a resilient framework for cellular structure and stability. Disrupting its integrity may result in irreparable damage, altering cellular homeostasis and ultimately leading to cell death. ATG9A, a transmembrane protein, has recently been implicated in plasma membrane repair. However, its role in the process and the mechanism by which it is targeted to the plasma membrane upon damage are unclear. We show here that glycosylation of ATG9A is essential for its membrane ...
-
作者：Malinow, Roberto
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Ketamine has been shown to reduce depression and suicidality in individuals resistant to treatment by other drugs. Exactly how ketamine works is not known. Here, I propose a new hypothesis that involves synaptic and circuit plasticity and may lead to enhanced efficacy in treating depression as well as other conditions.
